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The Chemotherapy of Dirofilaria Immitis
Herbert G. Johnstone
Herbert G. Johnstone
Pacific Institute of Tropical Medicine, Hooper Foundation, University of California, San Francisco
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Summary
- 1. The dog, harboring Dirofilaria immitis, serves as an appropriate laboratory animal for testing the filaricidal effect of drugs proposed for use in the treatment of human filariasis.
- 2. Fatal doses of fouadin given intramuscularly, within a short period of time caused a complete disappearance of the microfilariae from the peripheral blood of the dog, but exerted little or no damaging effect on the adult worms in the heart or pulmonary artery.
- 3. Carbarsone, hexylresorcinol, trypan blue or sodium-iodoantimonite did not possess any marked filaricidal or microfilaricidal qualities when tested on dogs infested with the heart-worm.
Author Notes
| Past two years | Past Year | Past 30 Days | |
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