Yellow Fever Virus Encephalitis in African and Asiatic Monkeys

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  • Laboratories of the West African Yellow Fever Commission, International Health Division, Rockefeller Foundation, Lagos, Nigeria

Since the original announcement of Theiler (1, 2) in 1930 of the establishment of a neurotropic strain of yellow fever virus in white mice, this strain or similar ones have been shown to be capable of producing encephalitis in various mammals. An acute virus encephalitis without specific lesions in tissues other than those of the nervous system follows the intracerebral inoculation of the mouse brain-adapted virus in the monkeys Macacus rhesus (3, 4, 5), Saimiri sciureus, Ateleus paniscus, Cebus frontatus, and Callithrix albicollis (6). Among rodents the guinea pig, like the mouse, is also susceptible to neurotropic yellow fever virus, and to a much lesser extent is the agouti (7, 8, 9). Findlay has recently demonstrated the susceptibility of the red squirrel and field vole to yellow fever virus encephalitis following the intracerebral inoculation of neurotropic virus (10).

In this place it is desired to record the production of experimental yellow fever virus encephalitis in one additional species of Asiatic monkey and in three species of African monkeys.