The Anthelmintic Properties of Certain Alkyl Phenols

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  • Department of Pharmacology, Vanderbilt University School of Medicine
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Several years ago a search was begun in this laboratory for a safe and effective human ascaricide. Among the many substances tested in vitro, hexylresorcinol was found to have as great activity as any and certain advantages which made its further study seem advisable (1). The results in human ascariasis have been encouraging as shown by the following reports of its use.

Quite incidentally the effect of hexylresorcinol against hookworm (2), trichuris (3), enterobius (4), etc., was studied but our chief object has been to find an effective ascaricide. As far as we can tell from laboratory experiments (5) and the reports of field treatments, a very effective and safe drug for uncomplicated hookworm disease is known in tetrachlorethylene which was first introduced into medicine in 1925 by Maurice C. Hall (6). As tetrachlorethylene is a poor ascaricide and may possibly stimulate ascaris to migrate, other treatment may be advantageous in mixed infestations, but, for uncomplicated hookworm, tetrachlorethylene is, as far as we know, the best drug which we have.