A Field Experiment in Quinine Treatment

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An attempt was made to compare the relative values of a prolonged and a short method of treatment with quinine, for the purpose of ascertaining their effects on recrudescences of malaria and on splenic enlargement.

The results show that recrudescences occur in 30 per cent of cases treated by the prolonged method as compared with 48 per cent of cases treated by the short method.

Patients receiving short treatment tend to remain free from subsequent attacks for considerably longer periods following treatment than do patients treated by the prolonged method.

Thirty-nine per cent of the patients receiving prolonged treatment showed decrease in spleen size during treatment, as compared with 27 per cent in the short-treatment group.