A Case of Histoplasmosis of Darling in an Infant

Katharine Dodd Departments of Pediatrics and Anatomy, Vanderbilt University School of Medicine, Nashville, Tennessee

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Edna H. Tompkins Departments of Pediatrics and Anatomy, Vanderbilt University School of Medicine, Nashville, Tennessee

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Summary

A case of fungus infection (histoplasmosis of Darling (1)) is reported in an infant in Tennessee.

The diagnosis was made from the blood during life by finding the characteristic parasite in the large mononuclear cells.

It seems probable that the part played by the large mononuclear cells in the plugging of blood vessels, in the collapse of the alveoli of the lungs, in the massive invasion of the bone marrow and in the destruction of red cells, may explain many of the symptoms of the disease.

The identity of the invading organism has been established in the Department of Pathology of this institution.

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