A Dengue Vaccine Prepared from Macacus Philippinensis

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A vaccine prepared from the liver and spleen of monkeys dying of yellow fever has been used by Hindle (1) and Aragao (2) with encouraging results. The marked similarity between yellow fever and dengue suggested that a vaccine similarly prepared from the liver and spleen of dengue infected monkeys might afford some protection against dengue infection.

It has been shown recently that Macacus philippinensis obtained from dengue free regions of the Philippine Islands, are susceptible to dengue and that the virus is present in the blood of the infected monkeys sometime between the third and ninth days following the application of infected mosquitoes (3). The experimental results given in this report show that the virus was present in one monkey on the sixth and in another on the seventh day following the feeding on them of dengue infected Aedes aegypti.


a. Origin of dengue virus.

Author Notes

Majors, Medical Corps, United States Army.