Nodular Fibrosis of the Spleen Associated with Filaria Loa

Oskar KlotzDepartment of Pathology, University of Toronto, Toronto, Canada

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  1. 1. Groups of microfilariae aggregate in the spleen of some cases of Filaria loa infection.
  2. 2. These areas of localization are associated with an inflammatory reaction and fibrosis.
  3. 3. A tissue eosinophilia accompanies the filarial inflammation.
  4. 4. These reactions in the spleen may be analogous to the external chronic Calabar swellings.