Nodular Fibrosis of the Spleen Associated with Filaria Loa

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  • Department of Pathology, University of Toronto, Toronto, Canada
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  1. 1.Groups of microfilariae aggregate in the spleen of some cases of Filaria loa infection.
  2. 2.These areas of localization are associated with an inflammatory reaction and fibrosis.
  3. 3.A tissue eosinophilia accompanies the filarial inflammation.
  4. 4.These reactions in the spleen may be analogous to the external chronic Calabar swellings.