Symmetrical Peripheral Gangrene in an Indian Child with Severe Scrub Typhus

Prasanna Samynathan Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;

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Neha Sharma Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;

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Priyanka Meena Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;

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Manisha Biswal Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

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Suresh Kumar Angurana Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;

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Scrub typhus is one of the common causes for acute febrile illness in monsoon and post-monsoon season in our region. It usually presents as fever, rash, and thrombocytopenia with or without multiorgan dysfunction syndrome (MODS). Infrequently, it can cause focal or symmetrical peripheral gangrene (SPG). Here, we report a 5-year-old female who presented with acute febrile illness with MODS and SPG in bilateral lower limbs. The diagnosis of scrub typhus was confirmed with positive scrub typhus IgM antibodies. She recovered completely after combination therapy with doxycycline and azithromycin, and organ supportive therapy (mechanical ventilation, vasoactive drugs, and continuous renal replacement therapy) in the pediatric intensive care unit.

Author Notes

Current contact information: Prasanna Samynathan, Neha Sharma, Priyanka Meena, and Suresh Kumar Angurana, Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mails: samyannampras@gmail.com, and sharma.nehasharma062@gmail.com. Manisha Biswal, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mail: manisha.biswal@gmail.com.

Address correspondence to Suresh Kumar Angurana, Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail: sureshangurana@gmail.com
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