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Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization–Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study
Jiayu Wen
Jiayu Wen
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China;
State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China
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State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China
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Jian-Qing He
jianqing_he@scu.edu.cn
Jian-Qing He
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China;
State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China
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State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China
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We compared the clinical characteristics and outcomes of active tuberculosis (TB) during pregnancy after in vitro fertilization–embryo transfer (IVF-ET) with those in natural pregnancies. The aim was to assess the impact of the mode of pregnancy on TB and to gain a deeper understanding of the clinical characteristics of TB during pregnancy in women who conceived through IVF-ET. This study retrospectively reviewed medical records to analyze maternal and perinatal outcomes in women with active TB during pregnancy, comparing those who conceived through IVF-ET with those who conceived naturally. Using a 1:2 propensity score matching method, this study included 37 pregnant women with active TB who conceived through IVF-ET and 74 matched pregnant women with active TB who conceived naturally. In the IVF-ET group, all patients developed TB during early to mid-pregnancy, with an average onset at 11 weeks. In contrast, the natural pregnancy group had a later onset, averaging 17 weeks (P = 0.002). The IVF-ET group had higher fever and miliary TB frequency than the natural pregnancy group (94.6% versus 62.2% and 74.3% versus 27.4%, respectively, P <0.05). Although there were no significant differences in maternal intensive care unit admission rates or TB-related mortality between the two groups (24.3% versus 18.9% and 2.7% versus 6.8%, respectively, P >0.05), the IVF-ET group showed higher fetal mortality (94.6% versus 56.8%, respectively, P <0.001). IVF-ET was found to contribute to the exacerbation and spread of TB, underscoring the need for enhanced screening in the future.
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Author Notes
Disclosures: The study received ethical approval from the Ethics Committee of West China Hospital, Sichuan University (no. 761 [2019]). All procedures adhered to the tenets of the Declaration of Helsinki. To maintain privacy, no personally identifiable information was included. Given the retrospective nature of the study and the anonymity of all patient data, the Ethics Committee of West China Hospital granted an exemption from informed consent. Furthermore, the study was conducted in compliance with national legislation and institutional requirements. We have no competing interests to declare that are relevant to the content of this article.
Authors’ contributions: J. Wen designed the article, collected data, and wrote the manuscript. J.-Q. He designed the article, administered the project, and reviewed and edited the manuscript.
Current contact information: Jiayu Wen and Jian-Qing He, Department of Respiratory and Critical Care Medicine and State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China, E-mails: 1922992826@qq.com and jianqing_he@scu.edu.cn.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 938 | 938 | 751 |
| Full Text Views | 25 | 25 | 6 |
| PDF Downloads | 8 | 8 | 3 |