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Comorbid Guillain-Barré Syndrome and Tuberculosis: A Case Study and Global Perspective
Gui-Hua Yang
Gui-Hua Yang
Department of Infectious Diseases, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China;
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Tu-Er Wan
Tu-Er Wan
Department of Radiology, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China
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Hui-Ping Song
Hui-Ping Song
Department of Infectious Diseases, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China;
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Hui-Wen Song
shw120@fjmu.edu.cn
Hui-Wen Song
Department of Infectious Diseases, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China;
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A 27-year-old man presented with a cough and progressive limb weakness. Initially diagnosed with pulmonary tuberculosis, he showed improvement in his cough after antituberculosis treatment (ATT). However, he subsequently developed worsening weakness and numbness in his lower limbs, leading to mobility loss and difficulty swallowing. A comprehensive diagnostic evaluation, including computed tomography of the lung, cranial magnetic resonance imaging, cerebrospinal fluid analysis, and electromyography, confirmed concurrent diagnoses of tuberculosis (TB) and Guillain-Barré syndrome (GBS). Treatment included immunoglobulin and corticosteroid therapy; however, his symptoms persisted, progressing to respiratory failure that required endotracheal intubation and plasma exchange therapy. After these interventions, his condition gradually improved, and he continued ATT, achieving a favorable recovery. A literature review identified 15 countries reporting cases of GBS associated with TB, with the highest incidence in India. Although most cases showed a positive prognosis, mortality rates were elevated in patients with comorbid TB and GBS compared to those with GBS alone.
Author Notes
Disclosures: Written informed consent was obtained from our patient to publish this case report and its accompanying images. A copy of the written consent form is available for review upon request.
Authors’ contributions: This research was conducted and improved by H.-W. Song. G.-H. Yang and T.-E. Wan were responsible for the literature search and drafting the manuscript. H.-P. Song and G.-H. Yang collected the clinical data. T.-E. Wan designed the schematic illustration and interpreted the CT results. All contributors reviewed and consented to the final version of the manuscript.
Current contact information: Gui-Hua Yang, Hui-Ping Song, and Hui-Wen Song, Department of Infectious Diseases, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China, E-mails: 13385096337@163.com, hp_song03@sina.com, and shw120@fjmu.edu.cn. Tu-Er Wan, Department of Radiology, Sanming First Hospital Affiliated with Fujian Medical University, Sanming, China, E-mail: wan1311004029@sina.com.
| Past two years | Past Year | Past 30 Days | |
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