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Development of Coup de Sabre in an HIV-Positive Patient: A Case Study from Lilongwe, Malawi
Katherine Naeger
katherine.naeger@bcm.edu
Katherine Naeger
Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas;
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Kia Quinlan
Kia Quinlan
Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas;
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Kelvin Jobo
Kelvin Jobo
Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi;
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Marietta DeGuzman
Marietta DeGuzman
Department of Rheumatology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas;
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Brigid E. O’Brien
Brigid E. O’Brien
Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi;
Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital, Houston, Texas
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Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital, Houston, Texas
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Jacob L. Todd
Jacob L. Todd
Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi;
Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital, Houston, Texas
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Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital, Houston, Texas
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Coup de Sabre is a subset of localized linear scleroderma disease influenced by autoimmune, vascular, and genetic factors. The disease often follows an active, relapsing, and remitting course causing the development of permanent sequelae, such as tissue atrophy, pigment alterations, and bony deformities. Treatment strategies have ranged from surgical to injectable and medical management approaches with varying success. Although more common in pediatric patients, Coup de Sabre remains rare, with limited literature available on disease course and treatment outcomes, particularly in the sub-Saharan African population. Furthermore, the existence of autoimmune conditions occurring simultaneously with HIV infection presents an interesting discussion of the interplay between antiretroviral medication, immune dysregulation, and autoimmunity. This case report describes an 11-year-old HIV-positive male in Lilongwe, Malawi with mixed subtype of localized scleroderma manifesting most prominently as Coup de Sabre that remained undiagnosed for 7 years.
Author Notes
Current contact information: Katherine Naeger, Kia Quinlan, and Marietta DeGuzman, Texas Children’s Hospital, Houston, TX, E-mails: katherine.naeger@bcm.edu, kia.quinlan@bcm.edu, and mmd@bcm.edu. Kelvin Jobo, Brigid E. O’Brien, and Jacob L. Todd, Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi, E-mails: kjobo@baylor-malawi.org, jacob.todd@bcm.edu, and brigid.o’brien@bcm.edu.
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