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Rotavirus Infection in Children Suffering from Diarrhea in Patna, Bihar Region, India: A Hospital-Based Study
Neetesh Jindal
Neetesh Jindal
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Ashish Kumar
Ashish Kumar
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Ashiq Hussain Bhat
Ashiq Hussain Bhat
Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Major Madhukar
Major Madhukar
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Roshan Kamal Topno
Roshan Kamal Topno
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Krishna Pandey
Krishna Pandey
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Ganesh Chandra Sahoo
ganeshiitkgp@gmail.com
Ganesh Chandra Sahoo
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Rotavirus (RV) is a leading cause of severe gastroenteritis in infants and young children, often resulting in dehydration and hospitalization. Although global data on RV is well-documented, there is limited information on its prevalence and genetic diversity in Bihar, India. This study aimed to investigate the prevalence of RV infections in the patient, from January 2021 to June 2024, and assess the associated molecular and epidemiological patterns. In this retrospective study conducted at the Rajendra Memorial Research Institute of Medical Sciences, Patna, 1,820 stool samples from patients suspected of RV infection were collected. Enzyme immunoassays were used to detect RV antigens, and positive samples were confirmed by real-time polymerase chain reaction targeting the VP4, VP6, and VP7 genes. Phylogenetic analysis was performed to examine genetic diversity. Results showed a 10% positivity rate for RV, with 5% showing equivocal results. The highest prevalence was in the 6–11 years age group (72 positive cases), followed by the 0–5 years group (62 positive cases). Prevalence decreased in older age groups, suggesting immunity through natural infection or vaccination. Phylogenetic analysis revealed distinct regional clusters and genetic variability between strains from Bihar and other parts of India, such as New Delhi and Kolkata. This study provides valuable baseline data on RV prevalence and genetic diversity in Bihar, emphasizing the need for vaccination and surveillance, particularly for younger children at higher risk. The observed genetic diversity suggests regional variations, highlighting the importance of continuous surveillance across India.
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Author Notes
Current contact information: Neetesh Jindal, Ashish Kumar, Major Madhukar, and Ganesh Chandra Sahoo, Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mails: jindalneetesh@gmail.com, ashish2k8@gmail.com, madhukarcaptpatna@gmail.com, and ganeshiitkgp@gmail.com. Ashiq Hussain Bhat, Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mail: ashiqhb14@gmail.com. Roshan Kamal Topno and Krishna Pandey, Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mails: roshanktopno@yahoo.co.in and pandey.krishna@icmr.gov.in
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 254 | 254 | 254 |
| Full Text Views | 8 | 8 | 8 |
| PDF Downloads | 4 | 4 | 4 |