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The Value of Fecal Calprotectin Combined with Procalcitonin in the Differential Diagnosis of Bacterial and Viral Diarrhea in Children
Qi Guo
qiguogq1925@163.com
Qi Guo
Department of Pediatrics, Anhui No.2 Provincial People’s Hospital, Hefei, China;
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Hui Guo
Hui Guo
Anhui Province Maternity & Child Health Hospital, Hefei, China
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Xia Xu
Xia Xu
Department of Pediatrics, Anhui No.2 Provincial People’s Hospital, Hefei, China;
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Infectious diarrhea frequently occurs in children, and accurate diagnosis is essential for providing prompt treatment. Fecal calprotectin (FC) and procalcitonin (PCT) are useful in differentiating types of infectious diarrhea. Therefore, this study aims to assess the value of combining FC and PCT in the differential diagnosis of bacterial and viral diarrhea in children. As a retrospective study, convenience sampling was used to include 60 children with acute bacterial diarrhea (bacterial group) and 70 children with acute viral diarrhea (viral group) who were admitted to hospitals in China between October 2019 and October 2021. The demographic characteristics, medical history, and laboratory data of the children were collected and compared. The proportions of children with myocardial and liver damage were lower in the bacterial group than in the viral group, and the proportions of children with bloody stool and purulent stool were higher in the bacterial group than in the viral group (all P <0.001). The levels of FC, PCT, C-reactive protein (CRP), and white blood cells (WBCs) were elevated in patients in the bacterial group compared with those in the viral group (all P <0.05). The FC, PCT, CRP, and WBC count values are valuable in the differential diagnosis of bacterial and viral diarrhea, and the area under the curve of FC combined with PCT for the differential diagnosis was the largest at 0.933, with a 95% CI of 0.856–0.955. Fecal calprotectin is superior to PCT, CRP, and WBC count in terms of guiding the differential diagnosis. The combination of FC and PCT provides better guidance for differential diagnosis than each indicator used individually.
Author Notes
Disclosures: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. This study was not supported by any funding. The original data are available upon request from the corresponding author. This study was approved by the hospital ethics committee, and the guardians of the participants signed informed consent forms.
Current contact information: Qi Guo and Xia Xu, Department of Pediatrics, Anhui No. 2 Provincial People’s Hospital, Hefei, China, E-mails: qiguogq1925@163.com and xu_xxxia22@21cn.com. Hui Guo, Anhui Province Maternity & Child Health Hospital, Hefei, China, E-mail: guohu_1205@21cn.com.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 252 | 252 | 252 |
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