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Changing Trends of Ralstonia Bacteremia in Patients at a Tertiary Care Center in North India: A 2-Year Retrospective Analysis
Ashima Jamwal
Ashima Jamwal
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Gerlin Varghese
Gerlin Varghese
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Sarvodaya Tripathy
Sarvodaya Tripathy
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Deepika Sarawat
Deepika Sarawat
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Sangram Singh Patel
Sangram Singh Patel
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Mitra Kar
Mitra Kar
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Nidhi Tejan
nidhiresearchsgpgi@gmail.com
Nidhi Tejan
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Chinmoy Sahu
chinmoyresearch@gmail.com
Chinmoy Sahu
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Ralstonia species are recently emerging as pathogens of human importance. This study was performed to assess the distribution of Ralstonia species among bacteremia patients and the clinical and demographical factors of these patients. This retrospective observational study was performed in the Microbiology Department of a tertiary care center in North India from April 2022 to April 2024. All in-patients with blood cultures positive for Ralstonia species for the first time during the study period were included in the study. Positive blood cultures were inoculated on blood and MacConkey agar. Identification was done by matrix-assisted laser desorption ionization–time of flight mass spectrometry, and antibiotic sensitivity testing was determined by disc diffusion assay. During the study period, 26 isolates of Ralstonia species were identified. R. mannitolilytica was the predominant isolate, followed by R. pickettii. Most patients with Ralstonia bacteremia belonged to the age group of <60 years (n = 20; 78%). The median age of the study population was 62 years. The male-to-female ratio was 1.6:1. Most of the patients presented with complaints of fever (77%), followed by epigastric pain (38.4%). Among the underlying comorbidities, most of the patients with Ralstonia bacteremia had sepsis (73%), followed by multiorgan dysfunction syndrome (30.7%). None of the R. mannitolilytica isolates showed sensitivity to imipenem, meropenem, aztreonam, and ceftazidime. On comparing both the isolates, R. pickettii showed better sensitivity to amikacin, imipenem, meropenem, aztreonam, and ceftazidime than R. mannitolilytica. Overall mortality of the patients in the study was 22% (n = 6).
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Author Notes
Disclosure: All authors have agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study design was approved by the Institutional Ethics Committee (IEC code: 2022-109-IMP-EXP-35).
Authors’ contributions: A. Jamwal conceived the work and acquired data. G. Varghese conceived the work. S. Tripathy contributed to clinical data collection. D. Sarawat and S. S. Patel analyzed data. M. Kar contributed to methods design. N. Tejan provided critical revisions to the manuscript and important intellectual content. C. Sahu provided final approval of the version to be published.
Current contact information: Ashima Jamwal, Gerlin Varghese, Sarvodaya Tripathy, Deepika Sarawat, Sangram Singh Patel, Mitra Kar, Nidhi Tejan, and Chinmoy Sahu, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. E-mails: ashi.jamwal@gmail.com, gerlinvarghese20@gmail.com, sarvo_trip@yahoo.co.in, docdeepika14@gmail.com, sangramresearch968@gmail.com, mitrakar25@gmail.com, nidhiresearchsgpgi@gmail.com, and chinmoyresearch@gmail.com.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 358 | 358 | 202 |
| Full Text Views | 6 | 6 | 4 |
| PDF Downloads | 10 | 10 | 7 |