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Association of Diabetes Mellitus with Presentation and Treatment Outcomes among Adult Patients with Pulmonary Tuberculosis
Rakesh Kumar
dr.rakesh3105@gmail.com
Rakesh Kumar
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
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Urvashi B Singh
Urvashi B Singh
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India;
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Ankit Chandra
Ankit Chandra
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
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Devasenathipathy Kandasamy
Devasenathipathy Kandasamy
Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India
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Anand Krishnan
Anand Krishnan
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
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This prospective study was done to compare the initial presentation and treatment outcomes of tuberculosis among adult patients who have diabetes mellitus with those without diabetes mellitus. In this study, all adult patients (age 18 years old or older) with microbiologically confirmed drug-sensitive pulmonary tuberculosis who were put on treatment in Ballabgarh block in Haryana were enrolled. Information on clinical, radiological, and microbiological parameters at baseline was obtained by interview or record review. Symptom score was calculated by assigning one point for each symptom from zero to seven. Patients were followed for 6 months from the start of treatment to assess treatment outcomes. Data were analyzed using the χ2 or Fisher exact test. Logistic regression was used to assess the factors associated with death or unfavorable outcomes. In total, 412 patients were included in the study, of which 17.5% had diabetes mellitus. The mean symptom scores among those with and without diabetes were 3.7 (SD 1.3) and 3.6 (SD 1.4), respectively. Treatment success was achieved in 83.6% of patients with diabetes and 86.4% of patients without diabetes. Death was observed in 12.3% of patients with diabetes compared with 7.1% of patients without diabetes. There was no significant difference in clinical presentation, radiology, or sputum smear grade at baseline between patients with or without diabetes. Although treatment success rate was less and death rate was higher in patients with tuberculosis who had diabetes compared with those who did not have diabetes, the difference was not statistically significant.
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Author Notes
Disclosures: Written informed consent was taken from all of the patients enrolled. Ethical approval for the study was obtained from the Institute Ethics Committee of the All India Institute of Medical Sciences, New Delhi. Data are available on request from the corresponding author.
Author’s contributions: R. Kumar, D. Kandasamy, and A. Krishnan were responsible for the concept and study design. R. Kumar, U. Singh, A. Chandra, and D. Kandasamy did the study implementation. R. Kumar, U. Singh, A. Chandra, D. Kandasamy, and A. Krishnan did the data analysis, interpreted results, critically reviewed, and approved the manuscript.
Current contact information: Rakesh Kumar, Ankit Chandra, and Anand Krishnan, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India, E-mails: dr.rakesh3105@gmail.com, suniyal3151@gmail.com, and anand.drk@gmail.com. Urvashi B Singh, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: drurvashi@gmail.com. Devasenathipathy Kandasamy, Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: devammc@gmail.com.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 6334 | 6334 | 6334 |
| Full Text Views | 41 | 41 | 41 |
| PDF Downloads | 29 | 29 | 29 |