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Clinical and Demographic Features Associated with the Isolation of Ceftriaxone-Resistant Enterobacteriaceae in a Private Hospital in Kingston, Jamaica
Matthew S. Mendoza
Matthew S. Mendoza
Loma Linda University School of Medicine, Loma Linda, California;
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Fredricka A. Coombs
Fredricka A. Coombs
Andrews Memorial Hospital, Kingston, Jamaica
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Hansel M. Fletcher
Hansel M. Fletcher
Loma Linda University School of Medicine, Loma Linda, California;
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Eugene W. Liu
eliu@llu.edu
Eugene W. Liu
Loma Linda University School of Medicine, Loma Linda, California;
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Data on the burden of extended-spectrum β-lactamase producing Enterobacterales are limited in Jamaica. This study aims to identify factors associated with the isolation of ceftriaxone-resistant Enterobacterales in patients at a private hospital in Jamaica through a retrospective case–control study comparing patients with and without ceftriaxone-resistant Enterobacterales in 2021. The case subjects had at least one Enterobacterales isolate resistant to ceftriaxone, and the controls had at least one culture, all without cephalosporin resistance, including those without growth. The data extracted included antibiotics received, organism, sex, and age. Older age, male sex, and the isolation of Enterobacter species were independently associated with increased odds of ceftriaxone-resistant Enterobacterales on logistic regression. Age and male sex may be markers for past exposure to β-lactam antibiotics or nosocomial infection with ceftriaxone-resistant Enterobacterales and may have a greater influence on isolation of ceftriaxone-resistant Enterobacterales compared with the receipt of antibiotics in the past six months, with which no association was observed on final analysis.
Author Notes
Financial support: This work was supported by the
Disclosures: This study was approved by the LLUH and AMH Institutional Review Boards (IRB #: 5220074), with an exempt determination indicating that consent was not required, wherein the use of protected health information involves no more than minimal risk to the privacy of individuals and could not practically be conducted without a waiver and the use of protected health information.
Current contact information: Matthew S. Mendoza and Eugene W. Liu, Loma Linda University School of Medicine, Loma Linda, CA, E-mails: matthewmendoza@students.llu.edu and eliu@llu.edu. Fredricka A. Coombs, Andrews Memorial Hospital, Kingston, Jamaica, E-mail: fcoombs@amhosp.org. Hansel M. Fletcher, Division of Microbiology and Molecular Genetics, Loma Linda University School of Medicine, Loma Linda, CA, E-mail: hfletcher@llu.edu.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 4159 | 4159 | 4159 |
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| PDF Downloads | 13 | 13 | 13 |