Increased Prevalence of Antibodies to Hepatitis E Virus in Patients with Neurocysticercosis

Jesus Abanto Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Neurology, University of Cincinnati, Cincinnati, Ohio;

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Arantxa N. Sanchez Boluarte Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Global Health, University of Washington, Seattle, Washington;

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Yesenia Castillo Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;

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Erika Perez Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

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Herbert Saavedra Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

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Isidro Gonzales Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

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Javier A. Bustos Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

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Florence Abravanel Laboratoire de Virologie, CHU Purpan, Toulouse, France;

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Jacques Izopet Laboratoire de Virologie, CHU Purpan, Toulouse, France;

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Richie G. Madden Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)

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Hector H. Garcia Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

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Harry R. Dalton Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)

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for the Cysticercosis Working Group in Peru
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We explored the association between serological status for hepatitis E and neurocysticercosis (NCC) in neurologic patients attending a national neurological referral center in Lima, Perú, between the years 2008 and 2012. Anti-hepatitis E antibodies were evaluated in patients with and without NCC, and a control group of rural general population. Anti-hepatitis E IgG was found in 23.8% of patients with NCC, compared with 14.3% in subjects without NCC from a general rural population (P = 0.023) and 14.4% in subjects with neurological complaints without NCC (P = 0.027). Seropositive patients had a median age of 44 years compared with 30 years in seronegative patients (P <0.001). No significant differences in sex, region of residence, or liver enzyme values were found. Seropositivity to hepatitis E was frequent in this Peruvian population and higher in patients with NCC, suggesting shared common routes of infection.

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Author Notes

Financial support: Beijing Wantai Biological donated the ELISA kits for detection of IgG and IgM antibodies against HEV used in this study. J. Abanto is partially supported by FIC NIH training grant TW001140.

Disclosure: The authors certify that they have no affiliations with or involvement in any entity with any financial interest.

Authors’ addresses: Jesus Abanto, Department of Neurology, University of Cincinnati, Cincinnati, OH, and Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: abantojs@ucmail.uc.edu. Arantxa N. Sanchez Boluarte, Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru, and Department of Global Health, University of Washington, Seattle, WA, E-mail: aransb21@uw.edu. Yesenia Castillo, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: yesenia.castillo.b@upch.pe. Erika Perez, Isidro Gonzales, and Herbert Saavedra, Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: erika.perez.p@upch.pe, isidrogonzalesq@hotmail.com, and hsaavedrapastor@hotmail.com. Javier A. Bustos and Hector H. Garcia, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, and Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: jbustos@jhsph.edu and hgarcia@jhsph.edu. Florence Abravanel and Jacques Izopet, Laboratoire de Virologie, CHU Purpan, Toulouse, France, E-mails: abravanel.f@chu-toulouse.fr and izopet.j@chu-toulouse.fr. Richie G. Madden and Harry R. Dalton, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, Australia, and HEV International Direct Action Group, E-mails: richie@forfey.com and hardalton@gmail.com.

Address correspondence to Arantxa N. Sanchez Boluarte, School of Medicine, Universidad Peruana Cayetano Heredia, Ave. Honorio Delgado 430, Lima 31, Peru. E-mail: aransb21@uw.edu
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