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Predictive Mortality of the Prognostic Nutritional Index Combined with APACHE II Score for Critically Ill Tuberculosis Patients
Qi Yuan
Qi Yuan
Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
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Wen Li
Wen Li
Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
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Kai Yang
Kai Yang
Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
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Jing Guo
Jing Guo
Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
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Yishan Zheng
zhengyishan@njucm.edu.cn
Yishan Zheng
Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
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High mortality rates are commonly found in critically ill patients with tuberculosis (TB), which is due partially to limitations in the existing prognostic evaluation methods. Therefore, we aimed to find more effective prognostic evaluation tools to reduce the mortality rate. Data from critically ill patients with TB admitted to the intensive care unit of The Second Hospital of Nanjing, Nanjing, China, between January 2020 and December 2022 were analyzed retrospectively. A total of 115 patients were enrolled and divided into a survival group (n = 62) and a death group (n = 53) according to 30-day survival. Univariate and least absolute shrinkage and selection operator (LASSO) regression analyses were used to investigate the risk factors for 30-day death in critically ill patients with TB. A prediction model for risk of 30-day mortality was developed for critically ill patients with TB in the intensive care unit. The LASSO regression model showed that the prognostic nutritional index (PNI) and Acute Physiology and Chronic Health Status (APACHE II) scores on the third day after admission to the intensive care unit were independent risk factors for 30-day mortality in critically ill patients with TB (P <0.05). The area under the curve value and that PA3 represents the combination of the PNI and APACHE II score on the third day, which was 0.952 (95% CI: 0.913–0.991, P <0.001), was significantly higher than that of the PNI or the APACHE II score on the third day. The new model is as follows: PA3 = APACHE II score (on the third day) × 0.421 – PNI × 0.204. The PNI combined with the APACHE II score on the third day could well predict the 30-day mortality risk of critically ill patients with TB.
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Author Notes
Financial support: This study was supported by the Project Plan of Special Fund for
Authors’ contributions: Q. Yuan participated in the conception, proposal development, data collection, and writing of the original draft. W. Li and K. Yang participated in acquisition of data, analysis, and interpretation of data for the work, and W. Li helped with the English. J. Guo and Y. Zheng participated in drafting the article or revising it critically for important intellectual content. All authors read and approved the final version of the manuscript.
Disclosure: The study was approved by the Ethics Committee of The Second Hospital of Nanjing (2020-LS-ky019). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.
Current contact information: Qi Yuan, Wen Li, Kai Yang, and Yishan Zheng, Department of Intensive Care Unit, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China, E-mails: 1007393442@qq.com, 18384229340@163.com, 326143722@qq.com, and guojing1984.10@163.com. Jing Guo, Department of Tuberculosis, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China, E-mail: zhengyishan@njucm.edu.cn.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 293 | 293 | 293 |
| Full Text Views | 4 | 4 | 4 |
| PDF Downloads | 6 | 6 | 6 |