Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®)

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  • 1 Department of Dermatology, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, Germany;
  • | 2 Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany;
  • | 3 Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany;
  • | 4 Pharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany;
  • | 5 Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany;
  • | 6 Medical Immunology Campus Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schlossplatz 1, Erlangen, Germany;
  • | 7 Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, Freiburg, Germany

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

Author Notes

Address correspondence to Christian Bogdan, Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany, E-mail: christian.bogdan@uk-erlangen.de or Kurt-Wilhelm Stahl, Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, D-79100 Freiburg, Germany, E-mail: stahlkw@waisenmedizin.org.

These authors contributed equally to this work.

Disclosure: The patients’ parents have given their written consent to the LeiProtect treatment and to the anonymous publication of the treatment results.

Authors’ addresses: Dirk Debus, Department of Dermatology, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, Nürnberg, Germany, E-mail: dirk.debus@klinikum-nuernberg.de. Semra Genç and Philipp Kurz, Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany, E-mails: semra.genc@ac.uni-freiburg.de and philipp.kurz@ac.uni-freiburg.de. Martin Holzer and Kurt Bauer, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany, E-mails: martin.holzer@pharmazie.uni-freiburg.de and bauer.kurt.freiburg@t-online.de. Ralph Heimke-Brinck and Martin Baier, Pharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany, E-mails: ralph.heimke-brinck@uk-erlangen.de and martin.baier@uk-erlangen.de. Heidi Sebald and Andrea Debus, Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany, E-mails: heidi.sebald@uk-erlangen.de and andrea.debus@uk-erlangen.de. Christian Bogdan, Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany, and Medical Immunology Campus Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schlossplatz 1, Erlangen, Germany, E-mail: christian.bogdan@uk-erlangen.de. Kurt-Wilhelm Stahl, Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, Freiburg, Germany, E-mail: stahlkw@waisenmedizin.org.

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