Epidemiological Characteristics and Risk Factors Related to Drug-resistant Tuberculosis in Luanda, Angola

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  • 1 Instituto Nacional de Investigação em Saúde, Luanda, Angola;
  • | 2 Centro de Investigação em Saúde de Angola (CISA), Caxito, Angola;
  • | 3 Instituto Superior de Ciências da Saúde (ISCISA), Universidade Agostinho Neto (UAN), Luanda, Angola;
  • | 4 Instituto Superior de Educação Física e Desporto, Luanda, Angola;
  • | 5 Faculdade de Medicina, Universidade Agostinho Neto, Luanda, Angola

Tuberculosis (TB) is a major cause of illness and public health concern, especially in resource-limited countries. This study analyzed the characteristics related to anti-TB drug resistance. Moreover, we examined the evidence-based indications for the treatment of active TB in Angola. This study evaluated the medical records of 176 patients screened for TB from January to September 2016 in Luanda, the capital city of Angola. Approximately 66.5% of the patients were newly diagnosed with active TB. The residence area showed a significant relationship with TB (P = 0.025), whereas age group (P = 0.272), gender (P = 0.853), and HIV status (P = 0.284) did not showed any relationship with TB. Overall, 72.4% of TB patients had resistance to at least one of the anti-TB drugs. The risk of anti-TB drug resistance was higher in males (odds ratio [OR]: 1.22; 95% confidence interval [CI]: 0.42–3.58, P = 0.685] and in TB-HIV coinfected patients [OR: 1.39; (95% CI: 0.26–7.28), P = 0.700], whereas it was lower in patients aged 30 years or older (OR: 0.56; 95% CI: 0.18–1.69) P = 0.303) and in patients living in urbanized areas (OR: 0.74; 95% CI: 0.17–3.25; P = 0.685). Our findings showed that drug-resistant TB is emerging in Angola. Further studies on factors related to anti-TB drug resistance are urgently needed to ascertain the magnitude of the problem and to proffer strategies toward TB control in Angola.

Author Notes

Address correspondence to Joana Morais, Instituto Nacional de Investigação em Saúde (INIS), Luanda, Angola. E-mail: jfm.morais9@gmail.com

Financial support: This research did not receive any specific grant from agencies in the public, commercial, or not-for-profit sectors.

Authors’ addresses: Cruz S. Sebastião, Instituto Nacional de Investigação em Saúde (INIS), Luanda, Angola, Centro de Investigação em Saúde de Angola (CISA), Angola, and Instituto Superior de Ciências da Saúde, Universidade Agostinho Neto, Luanda, Angola, E-mail: XXXXX. João Samulengo, Euclides Sacomboio, Ngiambudulu M. Francisco, Carlos Teixeira, Samuel António, Zoraima Neto, Joana Paixão, António Mateus, Zinga David, and Joana Morais, Instituto Nacional de Investigação em Saúde (INIS), Luanda, Angola, E-mails: XXXXX, XXXXX, XXXXX, XXXXX, XXXXX., XXXXX, XXXXX, XXXXX, XXXXX, and XXXXX. Mizele Kinanga, Instituto Superior de Educação Física e Desporto, Luanda, Angola. Joana Morais, Faculdade de Medicina, Universidade Agostinho Neto, Luanda, Angola, E-mail: jfm.morais9@gmail.com. Jocelyne Neto de Vasconcelos, Instituto Nacional de Investigação em Saúde (INIS), Luanda, Angola, and Centro de Investigação em Saúde de Angola (CISA), Angola, E-mail: XXXXX.

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