Congenital Chagas disease (CCD) has become a global health problem. Historically, the diagnosis of CCD has been carried out using parasitological methods and traditional serological techniques, however, new serological techniques such as chemiluminescent microparticle immunoassays (CMIA) have been developed in the last few years with many advantages compared with traditional serological tests. A total of 75 children born to 72 Latin American Chagas-infected mothers were consecutively enrolled and studied by CMIA and indirect immunofluorescence (IIF) at 0–2, 6, 9, and 12 months of age. At the end of the follow-up, 74 out of 75 children were considered uninfected and one child was diagnosed with CCD. Our study emphasizes the need to carry out serological follow-up on every newborn from a mother with Chagas disease and shows that CMIA assay is a great diagnostic tool as a single serological test at 9 months of age to rule out CCD or to identify possible transmission.
Address correspondence to Luis Gil-Gallardo, Unidad de Medicina Tropical, Hospital Clínico Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n 30120 El Palmar, Murcia, Spain. E-mail: email@example.com
Financial support: This study was supported by RICET the Tropical Diseases Research Network (RD16/0027/0016) from the Instituto de Salud Carlos III (ISCIII) and FEDER.