Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis

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  • 1 University of Washington School of Medicine, Seattle, Washington;
  • 2 Division of Infectious Diseases, University of Vermont Larner College of Medicine, Burlington, Vermont;
  • 3 Division of allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington;
  • 4 Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington

Cutaneous leishmaniasis (CL) is often caused by Leishmania braziliensis (L. braziliensis) in South America. Because of the risk for mucocutaneous leishmaniasis, L. braziliensis is frequently treated with parenteral or oral medications. Here, we present a case of a young woman with L. braziliensis (CL) that did not respond to miltefosine but eventually experienced spontaneous resolution. This case highlights the potential for treatment failure and the importance of clinical monitoring in the setting of cutaneous leishmaniasis caused by L. braziliensis.

Author Notes

Address correspondence to Anna L. Cogen, 4225 Roosevelt Way NE, 4th Floor, Seattle, WA 98103. E-mail: alcogen@uw.edu

Authors’ addresses: Sheridan Joseph, University of Washington School of Medicine, Seattle, WA, E-mail: sherjo@uw.edu. Timothy J. Whitman, Division of Infectious Diseases, University of Vermont, Larner College of Medicine, Burlington, VT, E-mail: timothy.whitman@uvmheath.org. Frederick Buckner, Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, E-mail: fbuckner@medicine.washington.edu. Anna L. Cogen, Division of Dermatology, Department of medicine, University of Washington, Seattle, WA, E-mail: alcogen@uw.edu.

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