Factors Associated with Unsuccessful Outcomes of Tuberculosis Treatment in 125 Municipalities in Colombia 2014 to 2016

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  • 1 Secretaria Seccional de Salud y Protección Social de Antioquia, Medellín, Colombia;
  • | 2 National Tuberculosis Program, Ministry of Health, Brasília, Brazil;
  • | 3 Research Department, School of Medicine, Universidad Pontificia Bolivariana, Medellín, Colombia;
  • | 4 Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada

Our aim was to identify the risk factors associated with unsuccessful outcomes of tuberculosis (TB) treatment in patients diagnosed between 2014 and 2016 in the 125 municipalities of Antioquia, Colombia. We studied a retrospective cohort of patients with TB diagnosed between 2014 and 2016, from national routine surveillance systems, in 125 municipalities of Antioquia. Factors associated with unsuccessful tuberculosis treatment outcomes (treatment failed, lost to follow up, or death) were identified utilizing a Poisson regression with robust variance. Over 3 years, of the 6,739 drug-susceptible tuberculosis patients, 73.4% had successful treatment and 26.6% unsuccessful outcomes (17% lost to follow up, 8.9% deaths, and 0.7% treatment failures). Patients with subsidized health insurance (Relative risk [RR]: 2.4; 95% CI: 2.1–2.8) and without health insurance (RR: 2.5; 95% CI: 2.1–3.0) had a higher risk for unsuccessful tuberculosis treatment compared to those with contributive health insurance. Other risk factors included age over 15 years, male sex, homelessness, people living with HIV, previous treatment, and primary diagnosis during hospitalization. Protective factors were living in a rural area and extrapulmonary disease. It is important to generate strategies that improves tuberculosis diagnosis in primary healthcare institutions. In addition, it is imperative to initiate new research about the barriers and obstacles related to patients, healthcare workers and services, and the health system, including the analysis of urban violence, to understand why the goal of TB treatment success has not been reached.

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Author Notes

Address correspondence to Zulma Vanessa Rueda, Department of Medical Microbiology and Infectious Diseases, Rady Faculty of Health Sciences, University of Manitoba, Rm 512, Basic Medical Sciences Building, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9. E-mail: zulmaruedav@gmail.com

Disclaimer: The content of this article does not reflect the official opinion of the Gobernación de Antioquia or Secretaria Seccional de Salud y Protección social de Antioquia. Responsibility for the information and views expressed in this article lies entirely with the authors.

Authors’ addresses: Lizeth Andrea Paniagua-Saldarriaga, Secretaria Seccional de Salud y Protección Social de Antioquia, Medellín, Colombia, E-mail: lpaniagua8@yahoo.es. Daniele Maria Pelissari, National Tuberculosis Program, Ministry of Health, Brasília, Brazil, E-mail: daniele.pelissari@gmail.com. Zulma Vanessa Rueda, Research Department, School of Medicine, Universidad Pontificia Bolivariana, Medellín, Colombia, and Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada, E-mail: zulmaruedav@gmail.com.

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