Omics Tools Applied to the Study of Chagas Disease Vectors: Cytogenomics and Genomics

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  • 1 Departamento de Física, Instituto de Biociências Letras e Ciências Exatas, Centro Multiusuário de Inovação Biomolecular, Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), São José do Rio Preto, Brazil;
  • 2 Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Laboratório de Parasitologia, Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Araraquara, Brazil

Chagas disease is an illness caused by the protozoan Trypanosoma cruzi that is distributed in 21 countries of Latin America. The main way of transmission of T. cruzi is through the feces of triatomines (Hemiptera and Triatominae) infected with the parasite. With technological advances came new technologies called omics. In the pre-genomic era, the omics science was based on cytogenomic studies of triatomines. With the Rhodnius prolixus genome sequencing project, new omics tools were applied to understand the organism at a systemic level and not just from a genomic point of view. Thus, the present review aims to put together the cytogenomic and genomic information available in the literature for Chagas disease vectors. Here, we review all studies related to cytogenomics and genomics of Chagas disease vectors, contributing to the direction of further research with these insect vectors, because it was evident that most studies focus on cytogenomic knowledge of the species. Given the importance of genomic studies, which contributed to the knowledge of taxonomy, systematics, as well as the vector’s biology, the need to apply these techniques in other genera and species of Triatominae subfamily is emphasized.

Author Notes

Address correspondence to Kelly Cristine Borsatto, Departamento de Física, Centro Multiusuário de Inovação Biomolecular, Instituto de Biociências Letras e Ciências Exatas, Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, Brazil. E-mail: kellyborsatto@gmail.com

Financial support: This work was financed by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (Process number 2018/25458–3) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) - Finance Code 001.

Authors’ addresses: Kelly Cristine Borsatto, Departamento de Biologia, Instituto de Biociencias Letras e Ciencias Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, Sao Jose do Rio Preto, Brazil, E-mail: kellyborsatto@gmail.com. Monika Aparecida Coronado and Raghuvir Krishnaswamy Arni, UNESP, Física, Sao Paulo, Brazil, E-mails: monikacoronado@gmail.com and raghuvir.arni@unesp.br. Kaio Cesar Chaboli Alevi, Departamento de Biologia, IBILCE, São José do Rio Preto, Brazil, E-mail: kaiochaboli@hotmail.com.

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