Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.
Address correspondence to Antonio C. Nicodemo, Rua Barata Ribeiro, 414 Conjunto 104, CEP 01308-000, São Paulo, Brazil. E-mail: firstname.lastname@example.org
Authors’ addresses: Antonio C. Nicodemo, Department of Infectious Diseases, University of São Paulo Medical School, São Paulo, Brazil, E-mail: email@example.com. Amaro Nunes Duarte-Neto, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil, E-mail: firstname.lastname@example.org.