ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2015. Chikungunya disease: gaps and opportunities in public health and research in the Americas [in English, French]. Wkly Epidemiol Rec 90: 571–576.
-
2.
Weaver SC, Lecuit M, 2015. Chikungunya vírus and the global spread of a mosquito-borne disease. N Engl J Med 13: 1231–1239.
-
3.
Halstead SB, 2015. Reappearance of chikungunya, formerly called dengue, in the Americas. Emerg Infect Dis 4: 557–561.
-
4.
Bastos MLA, Abreu FS, Silva Junior GBD, 2018. Inability to work due to chikungunya virus infection: impact on public service during the first epidemic in the state of Ceará, northeastern Brazil. Braz J Infect Dis 22: 248–249.
-
5.
Mercado M, Acosta-Reyes J, Parra E, Pardo L, Rico A, Campo A, Navarro E, Viasus D, 2016. Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015. Euro Surveill 21: 1–6.
-
6.
Mercado M, Acosta-Reyes J, Parra E, Guzmán L, Beltrán M, Gasque P, Mejía-García C, Viasus D, 2018. Renal involvement in fatal cases of chikungunya virus infection. J Clin Virol 103: 16–18.
-
7.
Alvarez MF, Bolívar-Mejía A, Rodriguez-Morales AJ, Ramirez-Vallejo E, 2017. Cardiovascular involvement and manifestations of systemic chikungunya virus infection: a systematic review. F1000 Res 6: 390.
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8.
Pierrotti LC, Lopes MIBF, Nascimento APD, Caiaffa-Filho H, Lemos FBC, Reusing JO Jr., Sejas ONE, David-Neto E, Azevedo LS, 2017. Chikungunya in kidney transplant recipients: a series of cases. Int J Infect Dis 64: 96–99.
-
9.
Lizarraga KJ, Nayer A, 2014. Dengue-associated kidney disease. J Nephropathol 3: 57–62.
-
10.
Alcendor DJ, 2017. Zika virus infection of the human glomerular cells: implications for viral reservoirs and renal pathogenesis. J Infect Dis 216: 162–171.
-
11.
Chen J et al. 2017. Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects. Emerg Microbes Infect 6: e77.
-
12.
Gurugama P, Jayarajah U, Wanigasuriya K, Wijewickrama A, Perera J, Seneviratne SL, 2018. Renal manifestations of dengue virus infections. J Clin Virol 101: 1–6.
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13.
Secretaria de Vigilância em Saúde, Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços. Ministry of Public Health, Brazil, 2017. Guia de Vigilância em Saúde. Available at: http://portalarquivos.saude.gov.br/images/pdf/2017/outubro/06/Volume-Unico-2017.pdf. Accessed June 21, 2018.
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Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group, 2013. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3: 1–150.
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15.
Freitas ARR, Cavalcanti L, Von Zuben AP, Donalisio MR, 2017. Excess mortality related to chikungunya epidemics in the context of co-circulation of other arboviruses in Brazil. PLoS Curr 9: 1–13.
-
16.
Kee ACL, Yang S, Tambyah P, 2010. Atypical chikungunya virus infections in immunocompromised patients. Emerg Infect Dis 16: 1038–1040.
-
17.
Tecklenborg J, Clayton D, Siebert S, Coley SM, 2018. The role of the immune system in kidney disease. Clin Exp Immunol 192: 142–150.
-
18.
Lang PO, Loulergue P, Aspinall R, 2017. Chikungunya virur infection: why should U.S. geriatricians be aware of it? J Am Geriatr Soc 11: 2529–2534.
-
19.
McClure M, Jorna T, Wilkinson L, Taylor J, 2017. Elderly patients with chronic kidney disease: do they really need referral to the nephrology clinic? Clin Kidney J 10: 698–702.
-
20.
Martina BE, Koraka P, Osterhaus AD, 2009. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 4: 564–581.
-
21.
Kulkarni SA, Strobelt E, Sargsyan Z, 2017. Capillary fragility in Zika virus infection. Am J Med 130: e59.
-
22.
Badawi A, Ryoo SG, Vasileva D, Yaghoubi S, 2018. Prevalence of chronic comorbidities in chikungunya: a systematic review and meta-analysis. Int J Infect Dis 67: 107–113.
-
23.
Cavalcanti LPG, D’angelo SM, Lemos DRQ, Barreto FKA, Siqueira AM, Miyajima F, 2018. Is the recent increment in attributable deaths to type-2 diabetes (T2D) associated with the latest chikungunya outbreak in a major epidemic area in Brazil? Rev Soc Bras Med Trop 51: 63–65.
-
24.
Gupta A, Juneja D, Singh O, Garg SK, Arora V, Deepak D, 2018. Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with chikungunya. Indian J Crit Care Med 22: 5–9.
-
25.
Godaert L, Bartholet S, Dorléans F, Najioullah F, Colas S, Fanon JL, Cabié A, Césaire R, Dramé M, 2018. Prognostic factors of inhospital death in elderly patients: a time-to-event analysis of a cohort study in Martinique (French West Indies). BMJ Open 8: e018838.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 580 | 358 | 35 |
| Full Text Views | 630 | 9 | 0 |
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Impact of Chronic Kidney Disease on Chikungunya Virus Infection Clinical Manifestations and Outcome: Highlights during an Outbreak in Northeastern Brazil
Geraldo Bezerra da Silva Junior
Geraldo Bezerra da Silva Junior
Post-Graduation Program in Collective Health, Health Sciences Center, University of Fortaleza-UNIFOR, Fortaleza, Brazil;
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José Reginaldo Pinto
José Reginaldo Pinto
Post-Graduation Program in Collective Health, Health Sciences Center, University of Fortaleza-UNIFOR, Fortaleza, Brazil;
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Rosa Maria Salani Mota
Rosa Maria Salani Mota
Department of Statistics and Applied Mathematics, Sciences Center, Federal University of Ceará-UFC, Fortaleza, Brazil;
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Roberto da Justa Pires Neto
Roberto da Justa Pires Neto
Post-Graduation Program in Public Health, Department of Community Health, Federal University of Ceará-UFC, Fortaleza, Brazil;
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Elizabeth De Francesco Daher
Elizabeth De Francesco Daher
Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará-UFC, Fortaleza, Brazil
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The northeastern region of Brazil has faced in the last 2 years the largest outbreak of chikungunya virus (CHIKV) infection in its history. There are still few studies on kidney involvement in CHIKV. The aim of this study is to describe the impact of chronic kidney disease (CKD) on CHIKV clinical manifestations and outcome. This is a cross-sectional study conducted in the State of Ceara, northeastern Brazil, including all registered cases of CHIKV infection in the period from January 2016 to December 2017. Clinical manifestations were collected from the notification reports from official data bank from the State Secretary of Health of Ceara: National System of Diseases Notification and Laboratory Manager. A total of 182,731 cases were notified. Patients’ mean age was 32.4 ± 14.6 years, and 62.2% were female. The most common clinical manifestations were fever (88.6%), headache (72.9%), intense arthralgia (69.5%), and myalgia (65.6%). Hospital admission was required for 3,080 cases (3.3%), and death occurred in 383 cases (0.2%). Chronic kidney disease was reported in 691 cases (0.3%). Patients with CKD had a higher frequency of almost all clinical manifestations, including fever, myalgia, exanthema, vomiting, nausea, back pain, conjunctivitis, arthritis, severe arthralgia, petechiae, and retro-orbital pain. They also had a significantly higher frequency of diabetes, hematological disorders, liver diseases, hypertension, peptic ulcer disease, and autoimmune diseases. Mortality was significantly higher among CKD patients than patients without CKD (3.0% versus 0.2%, P < 0.0001).
Author Notes
Authors’ addresses: Geraldo Bezerra da Silva Junior and José Reginaldo Pinto, School of Medicine, Master in Collective Health, University of Fortaleza, Fortaleza, Brazil, E-mails: geraldobezerrajr@yahoo.com.br and regis.med@hotmail.com. Rosa Maria Salani Mota, Department of Statistics and Applied Mathematics, Universidade Federal do Ceara, Fortaleza, Brazil, E-mail: rosa@ufc.br. Roberto da Justa Pires Neto, Post-Graduation Program in Public Health, Department of Community Health, Universidade Federal do Ceara, Fortaleza, Brazil, E-mail: robertojusta@gmail.com. Elizabeth De Francesco Daher, Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Universidade Federal do Ceara, Fortaleza, Brazil, E-mail: ef.daher@uol.com.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2015. Chikungunya disease: gaps and opportunities in public health and research in the Americas [in English, French]. Wkly Epidemiol Rec 90: 571–576.
-
2.
Weaver SC, Lecuit M, 2015. Chikungunya vírus and the global spread of a mosquito-borne disease. N Engl J Med 13: 1231–1239.
-
3.
Halstead SB, 2015. Reappearance of chikungunya, formerly called dengue, in the Americas. Emerg Infect Dis 4: 557–561.
-
4.
Bastos MLA, Abreu FS, Silva Junior GBD, 2018. Inability to work due to chikungunya virus infection: impact on public service during the first epidemic in the state of Ceará, northeastern Brazil. Braz J Infect Dis 22: 248–249.
-
5.
Mercado M, Acosta-Reyes J, Parra E, Pardo L, Rico A, Campo A, Navarro E, Viasus D, 2016. Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015. Euro Surveill 21: 1–6.
-
6.
Mercado M, Acosta-Reyes J, Parra E, Guzmán L, Beltrán M, Gasque P, Mejía-García C, Viasus D, 2018. Renal involvement in fatal cases of chikungunya virus infection. J Clin Virol 103: 16–18.
-
7.
Alvarez MF, Bolívar-Mejía A, Rodriguez-Morales AJ, Ramirez-Vallejo E, 2017. Cardiovascular involvement and manifestations of systemic chikungunya virus infection: a systematic review. F1000 Res 6: 390.
-
8.
Pierrotti LC, Lopes MIBF, Nascimento APD, Caiaffa-Filho H, Lemos FBC, Reusing JO Jr., Sejas ONE, David-Neto E, Azevedo LS, 2017. Chikungunya in kidney transplant recipients: a series of cases. Int J Infect Dis 64: 96–99.
-
9.
Lizarraga KJ, Nayer A, 2014. Dengue-associated kidney disease. J Nephropathol 3: 57–62.
-
10.
Alcendor DJ, 2017. Zika virus infection of the human glomerular cells: implications for viral reservoirs and renal pathogenesis. J Infect Dis 216: 162–171.
-
11.
Chen J et al. 2017. Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects. Emerg Microbes Infect 6: e77.
-
12.
Gurugama P, Jayarajah U, Wanigasuriya K, Wijewickrama A, Perera J, Seneviratne SL, 2018. Renal manifestations of dengue virus infections. J Clin Virol 101: 1–6.
-
13.
Secretaria de Vigilância em Saúde, Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços. Ministry of Public Health, Brazil, 2017. Guia de Vigilância em Saúde. Available at: http://portalarquivos.saude.gov.br/images/pdf/2017/outubro/06/Volume-Unico-2017.pdf. Accessed June 21, 2018.
-
14.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group, 2013. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3: 1–150.
-
15.
Freitas ARR, Cavalcanti L, Von Zuben AP, Donalisio MR, 2017. Excess mortality related to chikungunya epidemics in the context of co-circulation of other arboviruses in Brazil. PLoS Curr 9: 1–13.
-
16.
Kee ACL, Yang S, Tambyah P, 2010. Atypical chikungunya virus infections in immunocompromised patients. Emerg Infect Dis 16: 1038–1040.
-
17.
Tecklenborg J, Clayton D, Siebert S, Coley SM, 2018. The role of the immune system in kidney disease. Clin Exp Immunol 192: 142–150.
-
18.
Lang PO, Loulergue P, Aspinall R, 2017. Chikungunya virur infection: why should U.S. geriatricians be aware of it? J Am Geriatr Soc 11: 2529–2534.
-
19.
McClure M, Jorna T, Wilkinson L, Taylor J, 2017. Elderly patients with chronic kidney disease: do they really need referral to the nephrology clinic? Clin Kidney J 10: 698–702.
-
20.
Martina BE, Koraka P, Osterhaus AD, 2009. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 4: 564–581.
-
21.
Kulkarni SA, Strobelt E, Sargsyan Z, 2017. Capillary fragility in Zika virus infection. Am J Med 130: e59.
-
22.
Badawi A, Ryoo SG, Vasileva D, Yaghoubi S, 2018. Prevalence of chronic comorbidities in chikungunya: a systematic review and meta-analysis. Int J Infect Dis 67: 107–113.
-
23.
Cavalcanti LPG, D’angelo SM, Lemos DRQ, Barreto FKA, Siqueira AM, Miyajima F, 2018. Is the recent increment in attributable deaths to type-2 diabetes (T2D) associated with the latest chikungunya outbreak in a major epidemic area in Brazil? Rev Soc Bras Med Trop 51: 63–65.
-
24.
Gupta A, Juneja D, Singh O, Garg SK, Arora V, Deepak D, 2018. Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with chikungunya. Indian J Crit Care Med 22: 5–9.
-
25.
Godaert L, Bartholet S, Dorléans F, Najioullah F, Colas S, Fanon JL, Cabié A, Césaire R, Dramé M, 2018. Prognostic factors of inhospital death in elderly patients: a time-to-event analysis of a cohort study in Martinique (French West Indies). BMJ Open 8: e018838.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 580 | 358 | 35 |
| Full Text Views | 630 | 9 | 0 |
| PDF Downloads | 195 | 11 | 0 |