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1.
Fauci AS, Morens DM, 2016. Zika virus in the Americas–yet another Arbovirus threat. N Engl J Med 374: 601–604.
-
2.
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, Lanciotti RS, Tesh RB, 2011. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 17: 880–882.
-
3.
Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM, 2015. Potential sexual transmission of Zika virus. Emerg Infect Dis 21: 359–361.
-
4.
Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K, 2015. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 110: 569–572.
-
5.
Arauz D et al. 2016. Febrile or exanthematous illness associated with Zika, dengue, and chikungunya viruses, Panama. Emerg Infect Dis 22: 1515–1517.
-
6.
Salud Md, 2016. Boletines Semenales. Available at: http://www.minsa.gob.pa/informacion-salud/boletines-semanales. Accessed February 1, 2018.
-
7.
Mlakar J et al. 2016. Zika virus associated with microcephaly. N Engl J Med 374: 951–958.
-
8.
Cao-Lormeau VM et al. 2016. Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387: 1531–1539.
-
9.
Soares CN, Brasil P, Carrera RM, Sequeira P, de Filippis AB, Borges VA, Theophilo F, Ellul MA, Solomon T, 2016. Fatal encephalitis associated with Zika virus infection in an adult. J Clin Virol 83: 63–65.
-
10.
Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, Stanfield SM, Duffy MR, 2008. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14: 1232–1239.
-
11.
May M, Relich RF, 2016. A comprehensive systems biology approach to studying Zika virus. PLoS One 11: e0161355.
-
12.
Pruitt AA, 2014. Infections of the cerebellum. Neurol Clin 32: 1117–1131.
-
13.
Weeratunga PN, Caldera HP, Gooneratne IK, Gamage R, Perera WS, Ranasinghe GV, Niraj M, 2014. Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: a case series from Sri Lanka. Pract Neurol 14: 176–178.
-
14.
Withana M, Rodrigo C, Chang T, Karunanayake P, Rajapakse S, 2014. Dengue fever presenting with acute cerebellitis: a case report. BMC Res Notes 7: 125.
-
15.
Swaminathan S, Schlaberg R, Lewis J, Hanson KE, Couturier MR, 2016. Fatal Zika virus infection with secondary nonsexual transmission. N Engl J Med 375: 1907–1909.
-
16.
2016. Interim guidance for Zika virus testing of urine—United States, 2016. MMWR Morb Mortal Wkly Rep 65: 474.
-
17.
Tan SK, Sahoo MK, Milligan SB, Taylor N, Pinsky BA, 2017. Stability of Zika virus in urine: specimen processing considerations and implications for the detection of RNA targets in urine. J Virol Methods 248: 66–70.
-
18.
Blacksell SD et al. 2011. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 18: 2095–2101.
-
19.
Hunsperger EA et al. 2014. Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody. PLoS Negl Trop Dis 8: e3171.
-
20.
Brito CAA, Azevedo F, Cordeiro MT, Marques ETA Jr., Franca RFO, 2017. Central and peripheral nervous system involvement caused by Zika and chikungunya coinfection. PLoS Negl Trop Dis 11: e0005583.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 366 | 229 | 12 |
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Zika Virus–Associated Cerebellitis with Complete Clinical Recovery
Mónica R. Pachar
Mónica R. Pachar
Hospital Santo Tomas, Panama City, Panama;
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Dimelza Araúz
Dimelza Araúz
Gorgas Memorial Institute of Health Studies, Panama City, Panama;
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Nathan D. Gundacker
Nathan D. Gundacker
Medical College of Wisconsin, Milwaukee, Wisconsin
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Marixcel Suárez
Marixcel Suárez
Hospital Santo Tomas, Panama City, Panama;
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José Antonio Suárez
José Antonio Suárez
Gorgas Memorial Institute of Health Studies, Panama City, Panama;
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Brechla Moreno
Brechla Moreno
Gorgas Memorial Institute of Health Studies, Panama City, Panama;
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Sandra López-Vergès
Sandra López-Vergès
Gorgas Memorial Institute of Health Studies, Panama City, Panama;
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Ana B. Araúz
Ana B. Araúz
Hospital Santo Tomas, Panama City, Panama;
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Zika virus (ZIKV) was first detected in the Americas in Brazil in 2015, with a rapid spread to surrounding countries. In Panama, the outbreak began in November 2015 in an indigenous community located on the Caribbean side of the country. Zika virus is typically associated with a diffuse rash, fever, and conjunctivitis. It can rarely cause neurologic manifestations, most commonly microcephaly and Guillain–Barré syndrome. Encephalitis and acute encephalomyelitis are known complications, but ZIKV-associated cerebellitis has yet to be reported in the literature. Herein, we report a case of cerebellitis in a patient infected with ZIKV. This patient developed severe frontal headache and vertigo on the third day of illness, and dysarthria and ataxia on the fifth day. After 1 week of hospitalization, the patient completely recovered. The laboratory serological diagnosis was complicated because of the detection of antibodies against dengue, suggesting a secondary flavivirus infection.
Author Notes
These authors contributed equally to this work.
Financial support: This work has been carried out with management funds of HST and ICGES, as well as MEF. project 09044.051 (S. L. V.).
Authors’ addresses: Mónica R. Pachar, Marixcel Suárez, and Ana B. Araúz, Hospital Santo Tomas, Infectious Diseases, Panama City, Panama, E-mails: dra.pachar@hotmail.com, marixcel@gmail.com, and anabelenarauz@gmail.com. Dimelza Araúz, Brechla Moreno, and Sandra López-Vergès, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama, E-mails: darauz@gorgas.gob.pa, brechla@yahoo.es, and slopez@gorgas.gob.pa. José Antonio Suarez, Clinical Research Unit, Gorgas Memorial Institute of Health Studies, Panama City, Panama, E-mail: jsuarez@gorgas.gob.pa. Nathan D. Gundacker, Infectious Diseases, UAB Hospital, Birmingham, AL, E-mail: ndgundacker@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Fauci AS, Morens DM, 2016. Zika virus in the Americas–yet another Arbovirus threat. N Engl J Med 374: 601–604.
-
2.
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, Lanciotti RS, Tesh RB, 2011. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 17: 880–882.
-
3.
Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM, 2015. Potential sexual transmission of Zika virus. Emerg Infect Dis 21: 359–361.
-
4.
Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K, 2015. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 110: 569–572.
-
5.
Arauz D et al. 2016. Febrile or exanthematous illness associated with Zika, dengue, and chikungunya viruses, Panama. Emerg Infect Dis 22: 1515–1517.
-
6.
Salud Md, 2016. Boletines Semenales. Available at: http://www.minsa.gob.pa/informacion-salud/boletines-semanales. Accessed February 1, 2018.
-
7.
Mlakar J et al. 2016. Zika virus associated with microcephaly. N Engl J Med 374: 951–958.
-
8.
Cao-Lormeau VM et al. 2016. Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387: 1531–1539.
-
9.
Soares CN, Brasil P, Carrera RM, Sequeira P, de Filippis AB, Borges VA, Theophilo F, Ellul MA, Solomon T, 2016. Fatal encephalitis associated with Zika virus infection in an adult. J Clin Virol 83: 63–65.
-
10.
Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, Stanfield SM, Duffy MR, 2008. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14: 1232–1239.
-
11.
May M, Relich RF, 2016. A comprehensive systems biology approach to studying Zika virus. PLoS One 11: e0161355.
-
12.
Pruitt AA, 2014. Infections of the cerebellum. Neurol Clin 32: 1117–1131.
-
13.
Weeratunga PN, Caldera HP, Gooneratne IK, Gamage R, Perera WS, Ranasinghe GV, Niraj M, 2014. Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: a case series from Sri Lanka. Pract Neurol 14: 176–178.
-
14.
Withana M, Rodrigo C, Chang T, Karunanayake P, Rajapakse S, 2014. Dengue fever presenting with acute cerebellitis: a case report. BMC Res Notes 7: 125.
-
15.
Swaminathan S, Schlaberg R, Lewis J, Hanson KE, Couturier MR, 2016. Fatal Zika virus infection with secondary nonsexual transmission. N Engl J Med 375: 1907–1909.
-
16.
2016. Interim guidance for Zika virus testing of urine—United States, 2016. MMWR Morb Mortal Wkly Rep 65: 474.
-
17.
Tan SK, Sahoo MK, Milligan SB, Taylor N, Pinsky BA, 2017. Stability of Zika virus in urine: specimen processing considerations and implications for the detection of RNA targets in urine. J Virol Methods 248: 66–70.
-
18.
Blacksell SD et al. 2011. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 18: 2095–2101.
-
19.
Hunsperger EA et al. 2014. Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody. PLoS Negl Trop Dis 8: e3171.
-
20.
Brito CAA, Azevedo F, Cordeiro MT, Marques ETA Jr., Franca RFO, 2017. Central and peripheral nervous system involvement caused by Zika and chikungunya coinfection. PLoS Negl Trop Dis 11: e0005583.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 366 | 229 | 12 |
| Full Text Views | 608 | 14 | 0 |
| PDF Downloads | 138 | 13 | 0 |