Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Brasil Ministério da Saúde, Secretaria de Vigilância em Saúde, 2017. Manual de Vigilância da Leishmaniose Tegumentar. Brasília: Ministério da Saúde. Available at: http://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_leishmaniose_tegumentar.pdf. Accessed August 14, 2017.
-
2.
Calvopina M, Gomez EA, Uezato H, Kato H, Hashiguchi Y, 2005. Atypical clinical variants in new world cutaneous leishmaniasis: disseminated, erysipeloid, and recidivacutis due to Leishmania (V.) panamensis. Am J Trop Med Hyg 73: 281–284.
-
3.
Fernandes ACB, Pedroso RC, Venazzi EAS, Zanzarini PD, Aristides SMA, Lonardoni MVC, Silveira TG, 2016. American cutaneous leishmaniasis with unusual clinical presentation and response to treatment. Rev Inst Med Trop São Paulo 58: 1–4.
-
4.
Volpini AC, Passos VM, Oliveira GC, Romanha AJ, 2004. PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis. Acta Trop 90: 31–37.
-
5.
Cupolillo E, Grimaldi Júnior G, Momen H, 1995. Intergenic region typing (IRT): a rapid molecular approach to the characterization and evolution of Leishmania. Mol Biochem Parasitol 73: 145–155.
-
6.
Pires AS, Borges AF, Coelho AC, Dorta ML, Lino RS Jr., Pereira LIA, 2015. Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary Leishmania in Goiás, a nonendemic area for this species in Brazil. BioMed Res Int 2015: 1–11.
-
7.
Larkin MA et al. 2007. Clustal W and clustal X version 2.0. Bioinformatics 23: 2947–2948.
-
8.
Nicholas KB, Nicholas Júnior HB, Deerfield DW, 1997. GeneDoc: analysis and visualization of genetic variation. Embnew News 4: 1–4.
-
9.
Couppié P, Clyti E, Sainte-Marie D, Dedet JP, Carme B, Pradinaud R, 2004. Disseminated cutaneous leishmaniasis due to Leishmania guyanensis: case of a patient with 425 lesions. Am J Trop Med Hyg 71: 558–560.
-
10.
Hashiguchi Y, Gomez EL, Kato H, Martini LR, Velez LN, Uezato H, 2016. Diffuse and disseminated cutaneous leishmaniasis: clinical cases experienced in Ecuador and a brief review. Trop Med Health 44: 1–9.
-
11.
Carvalho EM, Barral A, Costa JML, Bittencourt A, Marsden PD, 1994. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Trop 56: 315–325.
-
12.
Silveira FT, Lainson R, Corbett CEP, 2004. Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil—a review. Mem Inst Oswaldo Cruz 99: 239–251.
-
13.
Hashiguchi Y, Gomez EL, Kato H, Martini LR, Velez LN, Uezato H, 2016. Diffuse and disseminated cutaneous leishmaniasis: clinical cases experienced in Ecuador and a brief review. Trop Med Health 44: 1–9.
-
14.
Silveira FT, Lainson R, Gomes CMC, Laurenti MD, Corbett CEP, 2008. Reviewing the role of the dendritic Langerhans cell in the immunopathogenesis of American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 102: 1075–1080.
-
15.
Ferreira AL, da Rocha AVE, Oliveira ML, Castilho MR, Teixeira CBR, Pinto SA, Dorta ML, Ribeiro-Dias F, Pereira LIA, 2016. A clinical case of disseminated cutaneous leishmaniasis in a young infant: early diagnosis. Trop Med Research 1: 1–3.
-
16.
Sgarbi IM, Santos FSD, Monteiro VE, Fonseca SNS, Bernardes Filho F, 2017. Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions. Braz J Infect Dis 21: 201–202.
-
17.
Chagas EJP, Ishikawa EA, Silveira FT, 2001. Humoral Response (IgG) in the Borderline Disseminated Cutaneous leishmaniasis (BDCL) Caused by Leishmania (L.) amazonensis in Pará State, Brazil. Crete, Greece: WOLRDleish 2, (P226), 118.
-
18.
Silveira FT, Lainson R, Corbett CEP, 2005. Further observations on clinical, histopathological and immunological features of borderline disseminated cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. Mem Inst Oswaldo Cruz 100: 525–534.
-
19.
Costa JM, Marsden PD, Llanos-Cuentas EA, Neto EM, Carvalho EM, Barral A, Rosa AC, Cuba CC, Magalhães AV, Barreto AC, 1986. Disseminated cutaneous leishmaniasis in a field clinic in Bahia, Brazil: a report of eight cases. J Trop Med Hyg 86: 319–323.
-
20.
Neves LO, Talhari AC, Gadelha EPN, Silva Júnior RM, Guerra JAO, Ferreira LCL, Talhari S, 2011. A randomized clinical trial comparing meglumine antimoniate, pentamidine and amphotericin B for the treatment of cutaneous leishmaniasis by Leishmania guyanensis. An Bras Dermatol 86: 1092–1101.
-
21.
Chrusciak-Talhari A, Dietze R, Chrusciak TC, da Silva RM, Gadelha YEP, de Oliveira PG, Lima MPR, Talhari S, 2011. Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis in Manaus, Brazil. Am J Trop Med Hyg 84: 255–260.
-
22.
Guimarães LH, Machado PRL, Lago EL, Morgan DJ, Schriefer A, Bacellar O, Carvalho EM, 2009. Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg 103: 712–715.
-
23.
Matta NE, Nogueira RS, Franco AM, de Souza SI, Mattos MS, Oliveira-Neto MP, Coutinho SG, Leon LL, Da-Cruz AM, 2009. Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazillian Amazon Highland. Am J Trop Med Hyg 80: 339–344.
-
24.
Scott P, Novais FO, 2016. Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nature 16: 581–592.
-
25.
Barbieri CL, Brown K, Rabinovitch M, 1985. Depletion of secondary lysosomes in mouse macrophages infected with Leishmania mexicana amazonensis: a cytochemical study. Z Parasitenkd 71: 159–168.
-
26.
Veras PS, de Chastellier C, Moreau MF, Villiers V, Thibon M, Mattei D, Rabinovitch M, 1994. Fusion between large phagocytic vesicles: targeting of yeast and other particulates to phagolysosomes that shelter the bacterium Coxiella burnetii or the protozoan Leishmania amazonensis in Chinese hamster ovary cells. J Cell Sci 107: 3065–3076.
-
27.
Souza WJS, Coutinho SG, Marzochi MCA, Toledo LM, Gottlieb MV, 1982. Utilização da reação de imunofluorescência indireta no acompanhamento da terapêutica da leishmaniose tegumentar americana. Mem Inst Oswaldo Cruz 77: 247–253.
-
28.
Chagas EJP, Corrêa CZ, Silveira FT, 1999. Avaliação da resposta imune humoral através do teste de imunofluorescência indireta na leishmaniose cutânea causada por Leishmania (L.) amazonensis na região Amazônica do Brasil. Rev Soc Med Trop 32: 26.
-
29.
Raja KM, Khan AA, Hameed A, Rahman SB, 1998. Unusual clinical variants of cutaneous leishmaniasis in Pakistan. Br J Dermatol 139: 111–113.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 373 | 244 | 14 |
| Full Text Views | 599 | 7 | 0 |
| PDF Downloads | 248 | 8 | 0 |
Case Report: Atypical Cutaneous Leishmaniasis in a Patient with Mixed Leishmania guyanensis and Leishmania amazonensis Infection
Carina Scolari Gosch
Carina Scolari Gosch
Department of Microbiology, Immunology and Parasitology, Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil;
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Bruna Silva Resende
Bruna Silva Resende
Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil;
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Célia Bastos Amorim
Célia Bastos Amorim
Department of Infectious Diseases, Specialized Attention Service of Porto Nacional, Tocantins, Brazil;
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Cálita Pollyanna Marques
Cálita Pollyanna Marques
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiás, Brazil;
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Ledice Inacia de Araújo Pereira
Ledice Inacia de Araújo Pereira
Department of Infectious Diseases, Hospital of Tropical Diseases Dr. Anuar Auad, Goiás, Brazil;
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Sebastião Alves Pinto
Sebastião Alves Pinto
Department of Pathology, Goiano Institute of Oncology and Hematology, Goiás, Brazil;
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Silvia Reni Bortolin Uliana
Silvia Reni Bortolin Uliana
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil;
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Adriano Cappellazzo Coelho
Adriano Cappellazzo Coelho
Department of Animal Biology, Institute of Biology, University of Campinas, São Paulo, Brazil
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Fátima Ribeiro-Dias
Fátima Ribeiro-Dias
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiás, Brazil;
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Miriam Leandro Dorta
Miriam Leandro Dorta
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiás, Brazil;
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The disseminated form of leishmaniasis is a serious and rare disease, being diagnosed in 2% of the cutaneous cases registered per year in Brazil. The main characteristic is the appearance of multiple pleomorphic lesions on the cutaneous surface. A 68-year-old male from the rural area of Tocantins, Brazil, presented atypical disseminated cutaneous leishmaniasis (ACL). The clinical course and histopathological and immunological findings presented a mixed pattern that hindered diagnosis and therapeutic management. Molecular typing revealed a mixed infection with Leishmania (V.) guyanensis and Leishmania (L.) amazonensis. Molecular identification of the agents responsible for ACL is important for adequate therapeutic planning, minimizing the possibility of sequellae that impact the quality of life of the patient.
Author Notes
Financial support: This study was funded by the research project “Epidemiology of American Cutaneous Leishmaniasis: molecular diagnosis of leishmaniasis species incident to the population of Tocantins,” funded by CNPq, in the FAPT/PPSUS Notice No. 01/2014, coordinated by Miriam Leandro Dorta, headquartered at the Faculdade Presidente Antônio Carlos—Porto Nacional (FAPAC / ITPAC-PORTO).
Authors’ addresses: Carina Scolari Gosch, Department of Microbiology, Immunology and Parasitology, Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil, E-mail: carinagosch@itpacporto.com.br. Bruna Silva Resende, Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil, E-mail: bruna_s.resende@hotmail.com. Célia Bastos Amorim, Department of Infectology, Specialized Attention Service of Porto Nacional, Tocantins, Brazil, E-mail: cbastosamorim@gmail.com. Cálita Pollyanna Marques, Fátima Ribeiro-Dias, and Miriam Leandro Dorta, Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiás, Brazil, E-mails: calitamarques@hotmail.com, fatimardias@gmail.com, and mledorta@gmail.com. Ledice Inacia de Araújo Pereira, Department of Infectology, Hospital for Tropical Diseases Dr. Anuar Auad, Goiás, Brazil, E-mail: ledicepereira@gmail.com. Sebastião Alves Pinto, Department of Pathology, Goiano Institute of Oncology and Hematology, Goiás, Brazil, E-mail: sebastiaoap@ingoh.com.br. Silvia Reni Bortolin Uliana, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, E-mail: srbulian@icb.usp.br. Adriano Cappellazzo Coelho, Department of Animal Biology, Institute of Biology, University of Campinas, São Paulo, Brazil, E-mail: ccadriano@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Brasil Ministério da Saúde, Secretaria de Vigilância em Saúde, 2017. Manual de Vigilância da Leishmaniose Tegumentar. Brasília: Ministério da Saúde. Available at: http://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_leishmaniose_tegumentar.pdf. Accessed August 14, 2017.
-
2.
Calvopina M, Gomez EA, Uezato H, Kato H, Hashiguchi Y, 2005. Atypical clinical variants in new world cutaneous leishmaniasis: disseminated, erysipeloid, and recidivacutis due to Leishmania (V.) panamensis. Am J Trop Med Hyg 73: 281–284.
-
3.
Fernandes ACB, Pedroso RC, Venazzi EAS, Zanzarini PD, Aristides SMA, Lonardoni MVC, Silveira TG, 2016. American cutaneous leishmaniasis with unusual clinical presentation and response to treatment. Rev Inst Med Trop São Paulo 58: 1–4.
-
4.
Volpini AC, Passos VM, Oliveira GC, Romanha AJ, 2004. PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis. Acta Trop 90: 31–37.
-
5.
Cupolillo E, Grimaldi Júnior G, Momen H, 1995. Intergenic region typing (IRT): a rapid molecular approach to the characterization and evolution of Leishmania. Mol Biochem Parasitol 73: 145–155.
-
6.
Pires AS, Borges AF, Coelho AC, Dorta ML, Lino RS Jr., Pereira LIA, 2015. Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary Leishmania in Goiás, a nonendemic area for this species in Brazil. BioMed Res Int 2015: 1–11.
-
7.
Larkin MA et al. 2007. Clustal W and clustal X version 2.0. Bioinformatics 23: 2947–2948.
-
8.
Nicholas KB, Nicholas Júnior HB, Deerfield DW, 1997. GeneDoc: analysis and visualization of genetic variation. Embnew News 4: 1–4.
-
9.
Couppié P, Clyti E, Sainte-Marie D, Dedet JP, Carme B, Pradinaud R, 2004. Disseminated cutaneous leishmaniasis due to Leishmania guyanensis: case of a patient with 425 lesions. Am J Trop Med Hyg 71: 558–560.
-
10.
Hashiguchi Y, Gomez EL, Kato H, Martini LR, Velez LN, Uezato H, 2016. Diffuse and disseminated cutaneous leishmaniasis: clinical cases experienced in Ecuador and a brief review. Trop Med Health 44: 1–9.
-
11.
Carvalho EM, Barral A, Costa JML, Bittencourt A, Marsden PD, 1994. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Trop 56: 315–325.
-
12.
Silveira FT, Lainson R, Corbett CEP, 2004. Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil—a review. Mem Inst Oswaldo Cruz 99: 239–251.
-
13.
Hashiguchi Y, Gomez EL, Kato H, Martini LR, Velez LN, Uezato H, 2016. Diffuse and disseminated cutaneous leishmaniasis: clinical cases experienced in Ecuador and a brief review. Trop Med Health 44: 1–9.
-
14.
Silveira FT, Lainson R, Gomes CMC, Laurenti MD, Corbett CEP, 2008. Reviewing the role of the dendritic Langerhans cell in the immunopathogenesis of American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 102: 1075–1080.
-
15.
Ferreira AL, da Rocha AVE, Oliveira ML, Castilho MR, Teixeira CBR, Pinto SA, Dorta ML, Ribeiro-Dias F, Pereira LIA, 2016. A clinical case of disseminated cutaneous leishmaniasis in a young infant: early diagnosis. Trop Med Research 1: 1–3.
-
16.
Sgarbi IM, Santos FSD, Monteiro VE, Fonseca SNS, Bernardes Filho F, 2017. Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions. Braz J Infect Dis 21: 201–202.
-
17.
Chagas EJP, Ishikawa EA, Silveira FT, 2001. Humoral Response (IgG) in the Borderline Disseminated Cutaneous leishmaniasis (BDCL) Caused by Leishmania (L.) amazonensis in Pará State, Brazil. Crete, Greece: WOLRDleish 2, (P226), 118.
-
18.
Silveira FT, Lainson R, Corbett CEP, 2005. Further observations on clinical, histopathological and immunological features of borderline disseminated cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. Mem Inst Oswaldo Cruz 100: 525–534.
-
19.
Costa JM, Marsden PD, Llanos-Cuentas EA, Neto EM, Carvalho EM, Barral A, Rosa AC, Cuba CC, Magalhães AV, Barreto AC, 1986. Disseminated cutaneous leishmaniasis in a field clinic in Bahia, Brazil: a report of eight cases. J Trop Med Hyg 86: 319–323.
-
20.
Neves LO, Talhari AC, Gadelha EPN, Silva Júnior RM, Guerra JAO, Ferreira LCL, Talhari S, 2011. A randomized clinical trial comparing meglumine antimoniate, pentamidine and amphotericin B for the treatment of cutaneous leishmaniasis by Leishmania guyanensis. An Bras Dermatol 86: 1092–1101.
-
21.
Chrusciak-Talhari A, Dietze R, Chrusciak TC, da Silva RM, Gadelha YEP, de Oliveira PG, Lima MPR, Talhari S, 2011. Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis in Manaus, Brazil. Am J Trop Med Hyg 84: 255–260.
-
22.
Guimarães LH, Machado PRL, Lago EL, Morgan DJ, Schriefer A, Bacellar O, Carvalho EM, 2009. Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg 103: 712–715.
-
23.
Matta NE, Nogueira RS, Franco AM, de Souza SI, Mattos MS, Oliveira-Neto MP, Coutinho SG, Leon LL, Da-Cruz AM, 2009. Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazillian Amazon Highland. Am J Trop Med Hyg 80: 339–344.
-
24.
Scott P, Novais FO, 2016. Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nature 16: 581–592.
-
25.
Barbieri CL, Brown K, Rabinovitch M, 1985. Depletion of secondary lysosomes in mouse macrophages infected with Leishmania mexicana amazonensis: a cytochemical study. Z Parasitenkd 71: 159–168.
-
26.
Veras PS, de Chastellier C, Moreau MF, Villiers V, Thibon M, Mattei D, Rabinovitch M, 1994. Fusion between large phagocytic vesicles: targeting of yeast and other particulates to phagolysosomes that shelter the bacterium Coxiella burnetii or the protozoan Leishmania amazonensis in Chinese hamster ovary cells. J Cell Sci 107: 3065–3076.
-
27.
Souza WJS, Coutinho SG, Marzochi MCA, Toledo LM, Gottlieb MV, 1982. Utilização da reação de imunofluorescência indireta no acompanhamento da terapêutica da leishmaniose tegumentar americana. Mem Inst Oswaldo Cruz 77: 247–253.
-
28.
Chagas EJP, Corrêa CZ, Silveira FT, 1999. Avaliação da resposta imune humoral através do teste de imunofluorescência indireta na leishmaniose cutânea causada por Leishmania (L.) amazonensis na região Amazônica do Brasil. Rev Soc Med Trop 32: 26.
-
29.
Raja KM, Khan AA, Hameed A, Rahman SB, 1998. Unusual clinical variants of cutaneous leishmaniasis in Pakistan. Br J Dermatol 139: 111–113.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 373 | 244 | 14 |
| Full Text Views | 599 | 7 | 0 |
| PDF Downloads | 248 | 8 | 0 |