Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Lopez A, Mathers C, Ezzati M, Jamison D, Murray C, 2006. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367: 1747–1757.
-
2.
Lawn J, Cousens S & Zupan JLancet Neonatal Survival Steering Team 2005. 4 millions neonatal deaths: when? where? why? Lancet 365: 891–900.
-
3.
Villar J, Belizan J, 1982. The relative contribution of prematurity and fetal growth retardation to low birth weight in developing and developed societies. Am J Obstet Gynecol 143: 793–798.
-
4.
Onguru D, Liang Y, Griffith Q, Nikolajczyk B, Mwinzi P, Ganley-Leal L, 2011. Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells. Am J Trop Med Hyg 84: 321–324.
-
5.
McDonald EA et al. 2014. Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments. J Infect Dis 209: 468–472.
-
6.
George P, Anuradha R, Kumar N, Kumaraswami V, Nutman T, Babu S, 2012. Evidence of microbial translocation associated with perturbations in T cell and antigen-presenting cell homeostasis in hookworm infections. PLoS Negl Trop Dis 6: e1830.
-
7.
Agrawal A et al. 2008. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend 93: 12–20.
-
8.
Chen P, Schnabl B, 2014. Host-microbiome interactions in alcoholic liver disease. Gut Liver 8: 237–241.
-
9.
Chen P, Starkel P, Turner J, Ho S, Schnabl B, 2015. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology 61: 883–894.
-
10.
Keshavarzian A, Fields J, Vaeth J, Holmes E, 1994. The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Am J Gastroenterol 89: 2205–2211.
-
11.
Bjareson I, Peters T, Wise R, 1984. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1: 179–182.
-
12.
Bode C, Kugler V, Bode J, 1987. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 4: 8–14.
-
13.
Xu DX, Chen YH, Wang H, Zhao L, Wang JP, Wei W, 2006. Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice. Toxicol Lett 163: 20–29.
-
14.
Holcberg G, Huleihel M, Sapir O, Katz M, Tsadkin M, Furman B, Mazor M, Myatt L, 2001. Increased production of tumor necrosis factor-alpha TNF-alpha by IUGR human placentae. Eur J Obstet Gynecol Reprod Biol 94: 69–72.
-
15.
Moormann A, Sullivan A, Rochford R, Chensue S, Bock P, Nyirenda T, Meshnick S, 1999. Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation. J Infect Dis 180: 1987–1993.
-
16.
Rogerson S, Brown H, Pollina E, Abrams E, Tadesse E, Lema V, Molyneux M, 2003. Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women. Infect Immun 71: 267–270.
-
17.
Hahn-Zoric M, Hagberg H, Kjellmer I, Ellis J, Wennergren M, Hanson L, 2002. Aberrations in placental cytokine mRNA related to intratuterine growth retardation. Pediatr Red 51: 201–206.
-
18.
Olveda R et al. 2016. Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Infect Dis 16: 199–208.
-
19.
Kurtis JD et al. 2011. Maternal schistosomiasis japonica is associated with maternal, placental, and fetal inflammation. Infect Immun 79: 1254–1261.
-
20.
McCarthy F et al. 2013. Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes. Obstet Gynecol 122: 830–837.
-
21.
Villar J et al. 2014. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 384: 857–868.
-
22.
Coutinho H et al. 2005. Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines. J Infect Dis 192: 528–536.
-
23.
Coutinho H et al. 2006. Pro-inflammatory cytokines and C-reactive protein are associated with undernutrition in the context of Schistosoma japonicum infection. Am J Trop Med Hyg 75: 720–726.
-
24.
Mutlu E, Gillevet P, Rangwala H, Sikaroodi M, Naqvi A, Engen P, Kwasny M, Lau C, Keshavarzian A, 2012. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 302: G966–G978.
-
25.
Leclercq S et al. 2014. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci USA 111: E4485–E4493.
-
26.
Parlesak A, Schafer C, Schutz T, Bode J, Bode C, 2000. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 32: 742–747.
-
27.
Backhed F, Normark S, Schweda E, Oscarson S, Richter-Dahlfors A, 2003. Structural requirements for TLR-4 mediated LPS signalling: a biological role for LPS modifications. Microbes Infect 5: 1057–1063.
-
28.
Cotechini T, Komisarenko M, Sperou A, MacDonald-Goodfellow S, Adams MA, Graham C, 2014. Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia. J Exp Med 211: 165–179.
-
29.
Gundogan F, Gilligan J, Qi W, Chen E, Naram R, de la Monte S, 2015. Dose effect of gestational ethanol exposure on placentation and fetal growth. Placenta 36: 523–530.
-
30.
Gonzalez-Fernandez D, Pons E, Rueda D, Sinisterra O, Murillo E, Scott ME, Koski KG, 2017. C-reactive protein is differentially modulated by co-existing infections, vitamin deficiences and maternal factors in pregnant and lactating indigenous Panamanian women. Infect Dis Poverty 6: 94.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 813 | 719 | 303 |
| Full Text Views | 804 | 31 | 1 |
| PDF Downloads | 133 | 22 | 2 |
Endotoxin at the Maternal–Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes
Emily A. McDonald
Emily A. McDonald
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Ronald Stuart
Ronald Stuart
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
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Ayush Joshi
Ayush Joshi
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
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Hannah W. Wu
Hannah W. Wu
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Remigio M. Olveda
Remigio M. Olveda
Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines;
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Luz P. Acosta
Luz P. Acosta
Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines;
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Veronica Tallo
Veronica Tallo
Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines;
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Palmera I. Baltazar
Palmera I. Baltazar
Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines;
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Jeffrey A. Bailey
Jeffrey A. Bailey
Division of Transfusion Medicine, University of Massachusetts Medical School, Worcester, Massachusetts;
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts;
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Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts;
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Jonathan D. Kurtis
Jonathan D. Kurtis
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island
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Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island
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Jennifer F. Friedman
Jennifer F. Friedman
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island;
Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island;
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Low- and middle-income countries (LMICs) carry a high burden of infectious diseases associated with impaired gut integrity, leading to microbial translocation. Pregnancies in this setting are at high risk of fetal growth restriction (FGR). We examined the association among specific risk factors for impaired gut integrity (schistosomiasis, hookworm infection, and alcohol consumption), blood endotoxin levels, and FGR. Endotoxins, lipopolysaccharide-binding proteins (LBPs), and cytokines were measured in blood from women at 32 weeks gestation, the maternal–fetal interface (MFI) at delivery, and cord blood at delivery. Resolution of schistosomiasis had no impact on endotoxin levels; however, maternal hookworm infection and alcohol consumption were associated with modest increases in endotoxin at the MFI. Cytokines responses within the maternal peripheral blood and blood from the MFI were positively associated with endotoxins, but many cord blood cytokines were negatively associated with endotoxins. Newborns with FGR also had higher levels of endotoxins at the MFI. Risk factors for microbial translocation may lead to increased levels of endotoxins at the MFI, which may contribute to poor growth in utero.
Author Notes
Financial support: This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (K24 AI112964 to J. F. F. and K01 AI113068 to E. A. M.).
Authors’ addresses: Emily A. McDonald, Ayush Joshi, Hannah W. Wu, and Jennifer F. Friedman, Center for International Health Research, Rhode Island Hospital, Providence, RI, E-mails: emily_mcdonald@brown.edu, ayush_joshi@brown.edu, haiwai_wu@brown.edu, and jennifer_friedman@brown.edu. Ronald Stuart and Jonathan D. Kurtis, Center for International Health Research, Brown University, Providence, RI, E-mails: ronald_stuart@brown.edu and jonathan_kurtis@brown.edu. Remigio M. Olveda, Luz P. Acosta, Veronica Tallo, and Palmera I. Baltazar, Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines, E-mails: rolvedamd_ritm_doh@yahoo.com, ipacosta@yahoo.com, veronica.tallo2015@gmail.com, and palmerabaltazar@yahoo.com. Jeffrey A. Bailey, Division of Transfusion Medicine, University of Massachusetts Medical School, Worcester, MA, E-mail: jeffrey.bailey@umassmed.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Lopez A, Mathers C, Ezzati M, Jamison D, Murray C, 2006. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367: 1747–1757.
-
2.
Lawn J, Cousens S & Zupan JLancet Neonatal Survival Steering Team 2005. 4 millions neonatal deaths: when? where? why? Lancet 365: 891–900.
-
3.
Villar J, Belizan J, 1982. The relative contribution of prematurity and fetal growth retardation to low birth weight in developing and developed societies. Am J Obstet Gynecol 143: 793–798.
-
4.
Onguru D, Liang Y, Griffith Q, Nikolajczyk B, Mwinzi P, Ganley-Leal L, 2011. Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells. Am J Trop Med Hyg 84: 321–324.
-
5.
McDonald EA et al. 2014. Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments. J Infect Dis 209: 468–472.
-
6.
George P, Anuradha R, Kumar N, Kumaraswami V, Nutman T, Babu S, 2012. Evidence of microbial translocation associated with perturbations in T cell and antigen-presenting cell homeostasis in hookworm infections. PLoS Negl Trop Dis 6: e1830.
-
7.
Agrawal A et al. 2008. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend 93: 12–20.
-
8.
Chen P, Schnabl B, 2014. Host-microbiome interactions in alcoholic liver disease. Gut Liver 8: 237–241.
-
9.
Chen P, Starkel P, Turner J, Ho S, Schnabl B, 2015. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology 61: 883–894.
-
10.
Keshavarzian A, Fields J, Vaeth J, Holmes E, 1994. The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Am J Gastroenterol 89: 2205–2211.
-
11.
Bjareson I, Peters T, Wise R, 1984. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1: 179–182.
-
12.
Bode C, Kugler V, Bode J, 1987. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 4: 8–14.
-
13.
Xu DX, Chen YH, Wang H, Zhao L, Wang JP, Wei W, 2006. Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice. Toxicol Lett 163: 20–29.
-
14.
Holcberg G, Huleihel M, Sapir O, Katz M, Tsadkin M, Furman B, Mazor M, Myatt L, 2001. Increased production of tumor necrosis factor-alpha TNF-alpha by IUGR human placentae. Eur J Obstet Gynecol Reprod Biol 94: 69–72.
-
15.
Moormann A, Sullivan A, Rochford R, Chensue S, Bock P, Nyirenda T, Meshnick S, 1999. Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation. J Infect Dis 180: 1987–1993.
-
16.
Rogerson S, Brown H, Pollina E, Abrams E, Tadesse E, Lema V, Molyneux M, 2003. Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women. Infect Immun 71: 267–270.
-
17.
Hahn-Zoric M, Hagberg H, Kjellmer I, Ellis J, Wennergren M, Hanson L, 2002. Aberrations in placental cytokine mRNA related to intratuterine growth retardation. Pediatr Red 51: 201–206.
-
18.
Olveda R et al. 2016. Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Infect Dis 16: 199–208.
-
19.
Kurtis JD et al. 2011. Maternal schistosomiasis japonica is associated with maternal, placental, and fetal inflammation. Infect Immun 79: 1254–1261.
-
20.
McCarthy F et al. 2013. Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes. Obstet Gynecol 122: 830–837.
-
21.
Villar J et al. 2014. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 384: 857–868.
-
22.
Coutinho H et al. 2005. Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines. J Infect Dis 192: 528–536.
-
23.
Coutinho H et al. 2006. Pro-inflammatory cytokines and C-reactive protein are associated with undernutrition in the context of Schistosoma japonicum infection. Am J Trop Med Hyg 75: 720–726.
-
24.
Mutlu E, Gillevet P, Rangwala H, Sikaroodi M, Naqvi A, Engen P, Kwasny M, Lau C, Keshavarzian A, 2012. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 302: G966–G978.
-
25.
Leclercq S et al. 2014. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci USA 111: E4485–E4493.
-
26.
Parlesak A, Schafer C, Schutz T, Bode J, Bode C, 2000. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 32: 742–747.
-
27.
Backhed F, Normark S, Schweda E, Oscarson S, Richter-Dahlfors A, 2003. Structural requirements for TLR-4 mediated LPS signalling: a biological role for LPS modifications. Microbes Infect 5: 1057–1063.
-
28.
Cotechini T, Komisarenko M, Sperou A, MacDonald-Goodfellow S, Adams MA, Graham C, 2014. Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia. J Exp Med 211: 165–179.
-
29.
Gundogan F, Gilligan J, Qi W, Chen E, Naram R, de la Monte S, 2015. Dose effect of gestational ethanol exposure on placentation and fetal growth. Placenta 36: 523–530.
-
30.
Gonzalez-Fernandez D, Pons E, Rueda D, Sinisterra O, Murillo E, Scott ME, Koski KG, 2017. C-reactive protein is differentially modulated by co-existing infections, vitamin deficiences and maternal factors in pregnant and lactating indigenous Panamanian women. Infect Dis Poverty 6: 94.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 813 | 719 | 303 |
| Full Text Views | 804 | 31 | 1 |
| PDF Downloads | 133 | 22 | 2 |