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Activity of Ceftolozane–Tazobactam against Burkholderia pseudomallei
We investigated the in vitro activity of a novel fifth-generation cephalosporin–tazobactam combination, ceftolozane–tazobactam against Burkholderia pseudomallei, the etiological agent of melioidosis. Using both disc diffusion and minimum inhibitory concentration (MIC) strip techniques against 56 clinical isolates and an national collection of type cultures (NCTC) strain, the MIC to ceftolozane–tazobactam was found to be between 0.75 and 4 mcg/mL. The MIC50 was found to be 1.5 mcg/mL and MIC90 was 2.0 mcg/mL. This study provides initial evidence of ceftolozane–tazobactam as a novel agent in the management of melioidosis.
Author Notes
Financial support: Financial support in the form of materials was supplied by Merck Sharp & Dohme Pty Ltd (MSD).
Authors’ addresses: Andrew Slack, Department of Infectious Diseases, Townsville Hospital and Health Service, Townsville, Australia, E-mail: at.slack@gmail.com. Fiona Parsonson, Katie Cronin, Cathy Engler, and Robert Norton, Department of Microbiology, Townsville Hospital, Townsville, Australia, E-mails: fiona.parsonson@health.qld.gov.au, katie.cronin@health.qld.gov.au, cathy.engler@health.qld.gov.au, and robert.norton@health.qld.gov.au.