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Dengue Fever as an Emerging Infection in Southeast Iran

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  • 1 Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;
  • | 2 Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Dengue fever (DF) is a mosquito-borne acute viral disease presenting with hemorrhagic manifestations in severe cases. Southeast Iran is in close proximity to Pakistan, an endemic country for DF. This cross-sectional study was conducted in the Sistan and Baluchestan province in the southeast of Iran to investigate possibility of DF (immunoglobulin M [IgM], immunoglobulin G [IgG], and nonstructural protein 1 [NS1] antigen tests) in 60 clinically suspected patients (April 2013 to August 2015). NS1 protein was detected in 5% (N = 3), at least one of the antibodies (IgM and/ or IgG) was detected in 11% (N = 7) of the samples. Five patients identified as of acutely infected. There was a simultaneous presence of NS1 protein and IgG or IgM antibodies in 4% (N = 2) of patients. Previous studies show establishment of potential vectors in this area. These evidences support the hypothesis that DF can be a health concern in Southeast Iran with potential future outbreaks.

Author Notes

Address correspondence to Maryam Keshtkar-Jahromi, Assistant Professor of Medicine, Johns Hopkins University School of Medicine, Division of Infectious Diseases, Mason F. Lord Building, Center Tower, 3rd Floor, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Baltimore, MD 21224. E-mail: maryam.keshtkar@jhmi.edu

Financial support: This study has been funded by Zahedan University of Medical Sciences.

Authors’ addresses: Mostafa Heydari, Maliheh Metanat, Mohammad-Ali Rouzbeh-Far, Seyed Mehdi Tabatabaei, Mohammad Rakhshani, and Nahid Sepehri-Rad, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, E-mails: mostafaheydari.m@gmail.com, mmetanat16@gmail.com, mashhadi172@gmail.com, zu.healthdeputy@gmail.com, rakhshani_dr@yahoo.com, and nahid_sepehri@yahoo.com. Maryam Keshtkar-Jahromi, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, E-mail: maryam.keshtkar@jhmi.edu.

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