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1.
Limmathurotsakul D, Kanoksil M, Wuthiekanun V, Kitphati R, deStavola B, Day NP, Peacock SJ, 2013. Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis 7: e2072.
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2.
Currie BJ, Jacups SP, Cheng AC, Fisher DA, Anstey NM, Huffam SE, Krause VL, 2004. Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia. Trop Med Int Health 9: 1167–1174.
-
3.
Limmathurotsakul D et al. 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
4.
Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ, 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
5.
Hoffmaster AR et al. 2015. Melioidosis diagnostic workshop, 2013. Emerg Infect Dis 21, doi:10.3201/eid2102.141045.
-
6.
Whitmore A, Krishnaswami CS, 1912. A hitherto undescribed infective disease in Rangoon. Ind Med Gaz 47: 262–267.
-
7.
Krishnaswami CS, 1917. Morphia injectors septicaemia. Ind Med Gaz 52: 296–299.
-
8.
Stanton AT, Fletcher W, 1921. Melioidosis, a New Disease of the Tropics. Weltevreden, Batavia, (Dutch East Indies): Far Eastern Association of Tropical Medicine. Transactions of the Fourth Congress. Vol. 2, 196–198.
-
9.
Wuthiekanun V, Langa S, Swaddiwudhipong W, Jedsadapanpong W, Kaengnet Y, Chierakul W, Day NP, Peacock SJ, 2006. Short report: melioidosis in Myanmar: forgotten but not gone? Am J Trop Med Hyg 75: 945–946.
-
10.
Aung MK, Mar TT, 2008. Re-emergence of melioidosis in Myanmar. Trans R Soc Trop Med Hyg 102 (Suppl 1): S10–S11.
-
11.
Chu CS, Winearls S, Ling C, Torchinsky MB, Phyo AP, Haohankunnathum W, Turner P, Wuthiekanun V, Nosten F, 2014. Two fatal cases of melioidosis on the Thai-Myanmar border. F1000 Res 3: 4.
-
12.
Suttisunhakul V, Wuthiekanun V, Brett PJ, Khusmith S, Day NP, Burtnick MN, Limmathurotsakul D, Chantratita N, 2016. Development of rapid enzyme-linked immunosorbent assays for detection of antibodies to Burkholderia pseudomallei. J Clin Microbiol 54: 1259–1268.
-
13.
Pumpuang A, Dunachie SJ, Phokrai P, Jenjaroen K, Sintiprungrat K, Boonsilp S, Brett PJ, Burtnick MN, Chantratita N, 2017. Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. PLoS Negl Trop Dis 11: e0005499.
-
14.
Currie BJ, 2015. Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment. Semin Respir Crit Care Med 36: 111–125.
-
15.
Burtnick MN, Brett PJ, 2013. Burkholderia mallei and Burkholderia pseudomallei cluster 1 type VI secretion system gene expression is negatively regulated by iron and zinc. PLoS One 8: e76767.
-
16.
Burtnick MN et al. 2011. The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun 79: 1512–1525.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 612 | 519 | 191 |
| Full Text Views | 1059 | 15 | 1 |
| PDF Downloads | 112 | 17 | 2 |
Use of Rapid Enzyme-Linked Immunosorbent Assays for Serological Screening of Melioidosis in Myanmar
Zin Zayar Win
Zin Zayar Win
Biomedical Research Division, Nay Pyi Taw, Myanmar;
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Phornpun Phokrai
Phornpun Phokrai
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;
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Zarni Aung
Zarni Aung
Biomedical Research Division, Nay Pyi Taw, Myanmar;
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Thein Zaw
Thein Zaw
Biomedical Research Division, Nay Pyi Taw, Myanmar;
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Mary N. Burtnick
Mary N. Burtnick
Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada;
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Narisara Chantratita
Narisara Chantratita
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;
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Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;
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Paul J. Brett
Paul J. Brett
Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada;
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Tin Maung Hlaing
Tin Maung Hlaing
Defence Services Medical Research Centre, Nay Pyi Taw, Myanmar
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Burkholderia pseudomallei, the etiologic agent of melioidosis, is an important but under-recognized cause of disease in the tropics. Although first described over a century ago as a septicemic illness associated with morphine addicts in Rangoon, Burma, there is little information regarding the incidence of melioidosis in present-day Myanmar. To address this issue, we used two recently developed and validated serological assays to detect B. pseudomallei–specific antibodies in 124 serum samples obtained from febrile patients in the delta region of Myanmar. Using cutoff values derived from culture-confirmed melioidosis cases in neighboring Thailand, 3.2% of the samples exhibited reactivity profiles consistent with active B. pseudomallei infections. Collectively, these findings indicate that melioidosis likely represents a significant cause of morbidity and mortality in Myanmar and support the need for further studies to assess the true burden of disease in this country.
Author Notes
Authors’ addresses: Zin Zayar Win, Zarni Aung, Thein Zaw, and Tin Maung Hlaing, Defence Services Medical Research Centre, Nay Pyi Taw, Myanmar, E-mails: zinzayarwin@gmail.com, jazz.mrc88@gmail.com, cotheinzaw@gmail.com, and hlaingtm@gmail.com. Phornpun Phokrai and Narisara Chantratita, Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, E-mails: ph.phornpun@gmail.com and narisara@tropmedres.ac. Mary N. Burtnick and Paul J. Brett, Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, E-mails: mburtnick@med.unr.edu and pbrett@med.unr.edu.
ProCite
RefWorks
Reference Manager
BibTeX
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-
1.
Limmathurotsakul D, Kanoksil M, Wuthiekanun V, Kitphati R, deStavola B, Day NP, Peacock SJ, 2013. Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis 7: e2072.
-
2.
Currie BJ, Jacups SP, Cheng AC, Fisher DA, Anstey NM, Huffam SE, Krause VL, 2004. Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia. Trop Med Int Health 9: 1167–1174.
-
3.
Limmathurotsakul D et al. 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
4.
Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ, 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
5.
Hoffmaster AR et al. 2015. Melioidosis diagnostic workshop, 2013. Emerg Infect Dis 21, doi:10.3201/eid2102.141045.
-
6.
Whitmore A, Krishnaswami CS, 1912. A hitherto undescribed infective disease in Rangoon. Ind Med Gaz 47: 262–267.
-
7.
Krishnaswami CS, 1917. Morphia injectors septicaemia. Ind Med Gaz 52: 296–299.
-
8.
Stanton AT, Fletcher W, 1921. Melioidosis, a New Disease of the Tropics. Weltevreden, Batavia, (Dutch East Indies): Far Eastern Association of Tropical Medicine. Transactions of the Fourth Congress. Vol. 2, 196–198.
-
9.
Wuthiekanun V, Langa S, Swaddiwudhipong W, Jedsadapanpong W, Kaengnet Y, Chierakul W, Day NP, Peacock SJ, 2006. Short report: melioidosis in Myanmar: forgotten but not gone? Am J Trop Med Hyg 75: 945–946.
-
10.
Aung MK, Mar TT, 2008. Re-emergence of melioidosis in Myanmar. Trans R Soc Trop Med Hyg 102 (Suppl 1): S10–S11.
-
11.
Chu CS, Winearls S, Ling C, Torchinsky MB, Phyo AP, Haohankunnathum W, Turner P, Wuthiekanun V, Nosten F, 2014. Two fatal cases of melioidosis on the Thai-Myanmar border. F1000 Res 3: 4.
-
12.
Suttisunhakul V, Wuthiekanun V, Brett PJ, Khusmith S, Day NP, Burtnick MN, Limmathurotsakul D, Chantratita N, 2016. Development of rapid enzyme-linked immunosorbent assays for detection of antibodies to Burkholderia pseudomallei. J Clin Microbiol 54: 1259–1268.
-
13.
Pumpuang A, Dunachie SJ, Phokrai P, Jenjaroen K, Sintiprungrat K, Boonsilp S, Brett PJ, Burtnick MN, Chantratita N, 2017. Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. PLoS Negl Trop Dis 11: e0005499.
-
14.
Currie BJ, 2015. Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment. Semin Respir Crit Care Med 36: 111–125.
-
15.
Burtnick MN, Brett PJ, 2013. Burkholderia mallei and Burkholderia pseudomallei cluster 1 type VI secretion system gene expression is negatively regulated by iron and zinc. PLoS One 8: e76767.
-
16.
Burtnick MN et al. 2011. The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun 79: 1512–1525.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 612 | 519 | 191 |
| Full Text Views | 1059 | 15 | 1 |
| PDF Downloads | 112 | 17 | 2 |