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Raja NS, Scarsbrook C, 2016. Burkholderia pseudomallei causing bone and joint infections: a clinical update. Infect Dis Ther 5: 17–29.
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Kaestli M, Mayo M, Harrington G, Harrington G, Ward L, Watt F, Hill JV, Cheng AC, Currie BJ, 2009. Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia. PLoS Negl Trop Dis 3: e364.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 513 | 426 | 90 |
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Epidemiological and Clinical Features of Melioidosis: A Report of Seven Cases from Southern Inland China
Yanping Tang
Yanping Tang
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Jingmin Deng
Jingmin Deng
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Jianquan Zhang
Jianquan Zhang
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Xiaoning Zhong
Xiaoning Zhong
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Ye Qiu
Ye Qiu
Department of Respiratory Medicine, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China
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Hui Zhang
Hui Zhang
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Haiguang Xu
Haiguang Xu
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;
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Some subtropical regions with similar climatic conditions to melioidosis-endemic areas, such as southern Guangxi, may be new endemic zones for melioidosis. We retrospectively reviewed seven culture-proven melioidosis patients from October 2006 to March 2015. Their clinical characteristics, diagnosis, and treatment, and the geographical and environmental factors were analyzed. Seven male patients lived at latitudes of 21–23°N in Beihai, Nanning, Chongzuo City of the Guangxi Province. Symptom onset occurred during the rainy season. All patients had pneumonia, six patients had diabetes, five patients had a history of wounds or exposure to soil or water, and two patients had liver and spleen abscesses. Most patients were misdiagnosed before the confirmatory laboratory testing. The final diagnosis was confirmed as melioidosis by isolation of Burkholderia pseudomallei in a culture of blood or pus. The 6- to 17-month treatment included carbapenems, ceftazidime, or other antibiotics active against the organism in vitro. All patients initially appeared cured, but two subsequently had recurrent melioidosis. In non-highly endemic areas, there is often a lack of awareness of melioidosis, and this leads to misdiagnoses. Other subtropical regions with climatic conditions similar to the highly melioidosis-endemic areas such as southern Guangxi may also be melioidosis endemic.
Author Notes
Authors’ addresses: Yanping Tang, Jingmin Deng, Jianquan Zhang, Xiaoning Zhong, Hui Zhang, and Haiguang Xu, Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China, E-mails: yptang2015@sina.com, 1623995863@qq.com, jqzhang2002@sina.com, 593066814@qq.com, 905301095@qq.com, and 474283068@qq.com. Ye Qiu, Department of Comprehensive Internal Medicine, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China, E-mail: 287063367@qq.com.
These authors contributed equally to this work.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1.
Whitmore A, Krishnaswami CS, 1912. An account of the discovery of a hitherto undescribed infective disease occurring among the population of Rangoon. Ind Med Gaz 47: 262–267.
-
2.
Brilhante RS et al. 2012. Clinical-epidemiological feautures of 13 cases of melioidosis in Brazil. J Clin Microbiol 50: 3349–3352.
-
3.
Liu X, Pang L, Sim SH, Goh KT, Ravikumar S, Win MS, Tan G, Cook AR, Fisher D, Chai LY, 2015. Association of melioidosis incidence with rainfall and humidity, Singapore, 2003–2012. Emerg Infect Dis 21: 159–162.
-
4.
Parameswaran U, Baird RW, Ward LM, Currie BJ, 2012. Melioidosis at Royal Darwin Hospital in the big 2009–2010 wet season: comparison with the preceding 20 years. Med J Aust 196: 345–348.
-
5.
Raja NS, Scarsbrook C, 2016. Burkholderia pseudomallei causing bone and joint infections: a clinical update. Infect Dis Ther 5: 17–29.
-
6.
Ysng S, 2000. Melioidosis research in China. Acta Trop 77: 157–165.
-
7.
Liu GN, Yang ML, Deng JM, Zhong XL, Zhang JQ, Jing B, 2010. Clinical manifestations of three cases with melioidosis [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi 33: 422–426.
-
8.
Kaestli M, Mayo M, Harrington G, Harrington G, Ward L, Watt F, Hill JV, Cheng AC, Currie BJ, 2009. Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia. PLoS Negl Trop Dis 3: e364.
-
9.
Limmathurotsakul D, Wuthiekanun V, Chantratita N, Wongsuvan G, Amornchai P, Day NP, Peacock SJ, 2010. Burkholderia pseudomallei is spatially distributed in soil in northeast Thailand. PLoS Negl Trop Dis 4: e694.
-
10.
Dan M, 2015. Melioidosis in travelers: review of the literature. J Travel Med 22: 410–414.
-
11.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
12.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
13.
Limmathurotsakul D, Chaowagul W, Chierakul W, Stepniewska K, Maharjan B, Wuthiekanun V, White NJ, Day NP, Peacock SJ, 2006. Risk factors for recurrent melioidosis in northeast Thailand. Clin Infect Dis 43: 979–986.
-
14.
Malczewski AB, Oman KM, Norton RE, Ketheesan N, 2005. Clinical presentation of melioidosis in Queensland, Australia. Trans R Soc Trop Med Hyg 99: 856–860.
-
15.
Lo TJ, Ang LW, James L, Goh KT, 2009. Melioidosis in a tropical city state, Singapore. Emerg Infect Dis 15: 1645–1647.
-
16.
Puthucheary SD, Parasakthi N, Lee MK, 1992. Septicaemic melioidosis: a review of 50 cases from Malaysia. Trans R Soc Trop Med Hyg 86: 683–685.
-
17.
Limmathurotsakul D, Peacock SJ, 2011. Melioidosis: a clinical overview. Br Med Bull 99: 125–139.
-
18.
Lipsitz R, Garges S, Aurigemma R, Baccam P, Blaney DD, Cheng AC, 2012. Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei infection, 2010. Emerg Infect Dis 18: e2.
-
19.
Dance D, 2014. Treatment and prophylaxis of melioidosis. Int J Antimicrob Agents 43: 310–318.
-
20.
Currie BJ, 2015. Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment. Semin Respir Crit Care Med 36: 111–125.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 513 | 426 | 90 |
| Full Text Views | 756 | 8 | 1 |
| PDF Downloads | 108 | 10 | 1 |