Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Franco E, Meleleo C, Serino L, Sorbara D, Zaratti L, 2012. Hepatitis A: epidemiology and prevention in developing countries. World J Hepatol 4: 68–73.
-
2.
Jacobsen KH, Wiersma ST, 2010. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine 28: 6653–6657.
-
3.
Kamar N, Dalton HR, Abravanel F, Izopet J, 2014. Hepatitis E virus infection. Clin Microbiol Rev 27: 116.
-
4.
Verghese VP, Robinson JL, 2014. A systematic review of hepatitis E virus infection in children. Clin Infect Dis 59: 689–697.
-
5.
Brown LM, 2000. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 22: 283–297.
-
6.
Binsaeed AA, 2010. Is there a link between seropositivity to Helicobacter pylori and hepatitis A virus? A systematic review. Int J Infect Dis 14: e567–e571.
-
7.
Bartoloni A, Aquilini D, Roselli M, Parri F, de Majo E, Nunez LE, Nicoletti P, Corti G, Paradisi F, 1989. Prevalence of antibody to hepatitis A virus in the Santa Cruz region of Bolivia. J Trop Med Hyg 92: 279–281.
-
8.
Bartoloni A, Bartalesi F, Roselli M, Mantella A, Arce CC, Paradisi F, Hall AJ, 1999. Prevalence of antibodies against hepatitis A and E viruses among rural populations of the Chaco region, south-eastern Bolivia. Trop Med Int Health 4: 596–601.
-
9.
Dell’Amico M et al. 2011. Hepatitis E virus genotype 3 in humans and swine, Bolivia. Emerg Infect Dis 17: 2–4.
-
10.
Jacobsen KH, 2009. The Global Prevalence of Hepatitis A Virus Infection and Susceptibility: A Systematic Review. Geneva, Switzerland: World Health Organization.
-
11.
Masuet-Aumatell C, Ramon-Torrell JM, Casanova-Rituerto A, Banque M, Lucı S, 2013. Prevalence of hepatitis A antibodies in eastern Bolivia: a population-based study. J Med Virol 85: 1692–1697.
-
12.
Gandolfo GM, Ferri GM, Conti L, Antenucci A, Marrone R, Frasca AM, Vitelli G, 2003. Prevalence of infections by hepatitis A, B, C and E viruses in two different socioeconomic groups of children from Santa Cruz, Bolivia. Med Clin (Barc) 120: 725–727.
-
13.
Tapia-Conyer R, Santos JI, Cavalcanti AM, Urdaneta E, Rivera L, Manterola A, Potin M, Ruttiman R, Tanaka Kido J, 1999. Hepatitis A in Latin America: a changing epidemiologic pattern. Am J Trop Med Hyg 61: 825–829.
-
14.
Tanaka J, 2000. Hepatitis A shifting epidemiology in Latin America. Vaccine 18 (Suppl 1): S57–S60.
-
15.
Echevarría JM, González JE, Lewis-Ximenez LL, Dos Santos DR, Munné MS, Pinto MA, Pujol FH, Rodríguez-Lay LA, 2013. Hepatitis E virus infection in Latin America: a review. J Med Virol 85: 1037–1045.
-
16.
Bendall RP, Ellis V, Ijaz S, Ali RJ, Dalton HR, 2010. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol 82: 799–805.
-
17.
Kmush BL, Labrique AB, Dalton HR, Ahmed ZB, Ticehurst JR, Heaney CD, Nelson KE, Zaman K, 2015. Two generations of “Gold Standards”: the impact of a decade in hepatitis E virus testing innovation on population seroprevalence. Am J Trop Med Hyg 93: 714–717.
-
18.
Izopet J et al. 2015. Hepatitis E virus seroprevalence in three hyperendemic areas: Nepal, Bangladesh and southwest France. J Clin Virol 70: 39–42.
-
19.
Mansuy JM et al. 2011. Hepatitis E virus antibodies in blood donors, France. Emerg Infect Dis 17: 2309–2312.
-
20.
Avellon A, Morago L, del Carmen MGG, Munoz M, Echevarría JM, 2015. Comparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection. J Med Virol 87: 1934–1939.
-
21.
Mirazo S, Ramos N, Russi JC, Arbiza J, 2013. Genetic heterogeneity and subtyping of human hepatitis E virus isolates from Uruguay. Virus Res 173: 364–370.
-
22.
Passos AM, Heringer TP, Medina-Pestana JO, Ferraz ML, Granato CF, 2013. First report and molecular characterization of hepatitis E virus infection in renal transplant recipients in Brazil. J Med Virol 85: 615–619.
-
23.
Munné MS et al. 2014. Updating the knowledge of hepatitis E: new variants and higher prevalence of anti-HEV in Argentina. Ann Hepatol 13: 496–502.
-
24.
Rendon J et al. 2016. Hepatitis E virus genotype 3 in Colombia: survey in patients with clinical diagnosis of viral hepatitis. PLoS One 11: e0148417.
-
25.
Purdy MA, Dell’Amico MC, Gonzales JL, Segundo H, Tolari F, Mazzei M, Bartoloni A, Khudyakov YE, 2012. Human and porcine hepatitis E viruses, southeastern Bolivia. Emerg Infect Dis 18: 339–340.
-
26.
Glynn MK, Friedman CR, Gold BD, Khanna B, Hutwagner L, Iihoshi N, Revollo C, Quick R, 2002. Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: acquisition and analysis of possible risk factors. Clin Infect Dis 35: 1059–1065.
-
27.
Santos IS et al. 2009. Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela. Public Health Nutr 12: 1862–1870.
-
28.
Sivapalasingam S, Rajasingham A, Macy JT, Friedman CR, Hoekstra RM, Ayers T, Gold B, Quick RE, 2014. Recurrence of Helicobacter pylori infection in Bolivian children and adults after a population-based ‘screen and treat’ strategy. Helicobacter 19: 343–348.
-
29.
Miftahussurur M, Yamaoka Y, 2016. Diagnostic methods of Helicobacter pylori infection for epidemiological studies: critical importance of indirect test validation. Biomed Res Int 2016: 4819423.
-
30.
Sierra MS, Cueva P, Bravo LE, Forman D, 2016. Stomach cancer burden in central and south America. Cancer Epidemiol 44: S62–S73.
-
31.
Macchioni F, Segundo H, Gabrielli S, Totino V, Gonzales PR, Salazar E, Bozo R, Bartoloni A, Cancrini G, 2015. Dramatic decrease in prevalence of soil-transmitted helminthiasis and new insight into intestinal protozoa in children living in the Chaco region, Bolivia. Am J Trop Med Hyg 92 (Suppl 4): 794–796.
-
32.
Macchioni F, Segundo H, Totino V, Gabrielli S, Rojas P, Roselli M, Paredes GA, Masana M, Bartoloni A, Cancrini G, 2016. Intestinal parasitic infections and associated epidemiological drivers in two rural communities of the Bolivian Chaco. J Infect Dev Ctries 10: 1012–1019.
-
33.
WHO, 2015. Water Sanitation and Hygiene 2015–2020: A Global Strategy for Accelerating and Sustaining Progress on Neglected Tropical Diseases. Geneva, Switzerland: World Health Organization.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 411 | 324 | 75 |
| Full Text Views | 800 | 7 | 0 |
| PDF Downloads | 134 | 9 | 0 |
Seroprevalence of Hepatitis A Virus, Hepatitis E Virus, and Helicobacter pylori in Rural Communities of the Bolivian Chaco, 2013
Irene Campolmi
Irene Campolmi
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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Michele Spinicci
Michele Spinicci
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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David Rojo Mayaregua
David Rojo Mayaregua
Escuela de Salud del Chaco Tekove Katu, Gutierrez, Plurinational State of Bolivia;
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Herlan Gamboa Barahona
Herlan Gamboa Barahona
Facultad Integral del Chaco, Universidad Autonoma Gabriel René Moreno, Camiri, Plurinational State of Bolivia;
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Antonia Mantella
Antonia Mantella
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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Yunni Lara
Yunni Lara
Hospital S. Antonio de Los Sauces, Monteagudo, Plurinational State of Bolivia;
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Mimmo Roselli
Mimmo Roselli
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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Marianne Strohmeyer
Marianne Strohmeyer
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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Giampaolo Corti
Giampaolo Corti
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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Francesco Tolari
Francesco Tolari
Dipartimento di Scienze Veterinarie, Università di Pisa, Pisa, Italy;
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Joaquín Monasterio Pinckert
Joaquín Monasterio Pinckert
Servicio Departamental de Salud de Santa Cruz, Santa Cruz, Plurinational State of Bolivia;
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Harry R. Dalton
Harry R. Dalton
European Centre for Environment and Human Health, University of Exeter Medical School, Truro, United Kingdom
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Alessandro Bartoloni
Alessandro Bartoloni
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy;
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In the Bolivian Chaco, south-east of Bolivia, studies conducted over the past three decades reported hepatitis A virus (HAV) and Helicobacter pylori seroprevalences above 90% and 60%, respectively. Hepatitis E virus (HEV) prevalence was previously found to be 6–7% but is probably an underestimate because of the poor sensitivity of the assays used. In November 2013, we conducted a cross-sectional study of 263 healthy volunteers from two rural communities of the Bolivian Chaco, aiming to reassess HAV, HEV, and H. pylori seroprevalence 10–20 years following the previous surveys. Hepatitis A virus seroprevalence was 95%, with universal exposure after the first decade of life; HEV seroprevalence was considerably higher (31–35%) than that previously reported; H. pylori seroprevalence was 59%, with an age-dependent distribution. The high prevalence of these infections suggests that major efforts are still needed to reduce fecal–oral transmission and to improve human health in the Bolivian Chaco.
Author Notes
Financial support: The study was supported by grants from the Regione Toscana (Italy), Progetti di Iniziativa Regionale (PIR) 2015 (‘Supporto al miglioramento della condizione di salute della popolazione del Chaco Boliviano’).
Authors’ addresses: Irene Campolmi, Michele Spinicci, Antonia Mantella, Mimmo Roselli, Marianne Strohmeyer, Giampaolo Corti, and Alessandro Bartoloni, Università degli Studi di Firenze, Florence, Italy, E-mails: irenecampolmi@yahoo.it, michele.spinicci@unifi.it, antoniamantella@libero.it, mimrose@tin.it, marianne.strohmeyer@unifi.it, giampaolo.corti@unifi.it, and alessandro.bartoloni@unifi.it. David Rojo Mayaregua, Escuela de Salud del Chaco Tekove Katu, Gutierrez, Plurinational State of Bolivia, E-mail: davidrojomayaregua@gmail.com. Herlan Gamboa Barahona, Universidad Autonoma Gabriel René Moreno, Camiri, Plurinational State of Bolivia, E-mail: herlan.gamboa@hotmail.com. Yunni Lara, Hospital S. Antonio de Los Sauces, Monteagudo, Plurinational State of Bolivia, E-mail: yulamo77@hotmail.com. Francesco Tolari, Università di Pisa, Pisa, Italy, E-mail: francesco.tolari@gmail.com. Joaquín Monasterio Pinckert, Servicio Departamental de Salud de Santa Cruz, Santa Cruz, Plurinational State of Bolivia, E-mail: joaquinmpinckert@hotmail.com. Harry R. Dalton, University of Exeter Medical School, Truro, United Kingdom, E-mail: hardalton@gmail.com.
These authors contributed equally to this work.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Franco E, Meleleo C, Serino L, Sorbara D, Zaratti L, 2012. Hepatitis A: epidemiology and prevention in developing countries. World J Hepatol 4: 68–73.
-
2.
Jacobsen KH, Wiersma ST, 2010. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine 28: 6653–6657.
-
3.
Kamar N, Dalton HR, Abravanel F, Izopet J, 2014. Hepatitis E virus infection. Clin Microbiol Rev 27: 116.
-
4.
Verghese VP, Robinson JL, 2014. A systematic review of hepatitis E virus infection in children. Clin Infect Dis 59: 689–697.
-
5.
Brown LM, 2000. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 22: 283–297.
-
6.
Binsaeed AA, 2010. Is there a link between seropositivity to Helicobacter pylori and hepatitis A virus? A systematic review. Int J Infect Dis 14: e567–e571.
-
7.
Bartoloni A, Aquilini D, Roselli M, Parri F, de Majo E, Nunez LE, Nicoletti P, Corti G, Paradisi F, 1989. Prevalence of antibody to hepatitis A virus in the Santa Cruz region of Bolivia. J Trop Med Hyg 92: 279–281.
-
8.
Bartoloni A, Bartalesi F, Roselli M, Mantella A, Arce CC, Paradisi F, Hall AJ, 1999. Prevalence of antibodies against hepatitis A and E viruses among rural populations of the Chaco region, south-eastern Bolivia. Trop Med Int Health 4: 596–601.
-
9.
Dell’Amico M et al. 2011. Hepatitis E virus genotype 3 in humans and swine, Bolivia. Emerg Infect Dis 17: 2–4.
-
10.
Jacobsen KH, 2009. The Global Prevalence of Hepatitis A Virus Infection and Susceptibility: A Systematic Review. Geneva, Switzerland: World Health Organization.
-
11.
Masuet-Aumatell C, Ramon-Torrell JM, Casanova-Rituerto A, Banque M, Lucı S, 2013. Prevalence of hepatitis A antibodies in eastern Bolivia: a population-based study. J Med Virol 85: 1692–1697.
-
12.
Gandolfo GM, Ferri GM, Conti L, Antenucci A, Marrone R, Frasca AM, Vitelli G, 2003. Prevalence of infections by hepatitis A, B, C and E viruses in two different socioeconomic groups of children from Santa Cruz, Bolivia. Med Clin (Barc) 120: 725–727.
-
13.
Tapia-Conyer R, Santos JI, Cavalcanti AM, Urdaneta E, Rivera L, Manterola A, Potin M, Ruttiman R, Tanaka Kido J, 1999. Hepatitis A in Latin America: a changing epidemiologic pattern. Am J Trop Med Hyg 61: 825–829.
-
14.
Tanaka J, 2000. Hepatitis A shifting epidemiology in Latin America. Vaccine 18 (Suppl 1): S57–S60.
-
15.
Echevarría JM, González JE, Lewis-Ximenez LL, Dos Santos DR, Munné MS, Pinto MA, Pujol FH, Rodríguez-Lay LA, 2013. Hepatitis E virus infection in Latin America: a review. J Med Virol 85: 1037–1045.
-
16.
Bendall RP, Ellis V, Ijaz S, Ali RJ, Dalton HR, 2010. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol 82: 799–805.
-
17.
Kmush BL, Labrique AB, Dalton HR, Ahmed ZB, Ticehurst JR, Heaney CD, Nelson KE, Zaman K, 2015. Two generations of “Gold Standards”: the impact of a decade in hepatitis E virus testing innovation on population seroprevalence. Am J Trop Med Hyg 93: 714–717.
-
18.
Izopet J et al. 2015. Hepatitis E virus seroprevalence in three hyperendemic areas: Nepal, Bangladesh and southwest France. J Clin Virol 70: 39–42.
-
19.
Mansuy JM et al. 2011. Hepatitis E virus antibodies in blood donors, France. Emerg Infect Dis 17: 2309–2312.
-
20.
Avellon A, Morago L, del Carmen MGG, Munoz M, Echevarría JM, 2015. Comparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection. J Med Virol 87: 1934–1939.
-
21.
Mirazo S, Ramos N, Russi JC, Arbiza J, 2013. Genetic heterogeneity and subtyping of human hepatitis E virus isolates from Uruguay. Virus Res 173: 364–370.
-
22.
Passos AM, Heringer TP, Medina-Pestana JO, Ferraz ML, Granato CF, 2013. First report and molecular characterization of hepatitis E virus infection in renal transplant recipients in Brazil. J Med Virol 85: 615–619.
-
23.
Munné MS et al. 2014. Updating the knowledge of hepatitis E: new variants and higher prevalence of anti-HEV in Argentina. Ann Hepatol 13: 496–502.
-
24.
Rendon J et al. 2016. Hepatitis E virus genotype 3 in Colombia: survey in patients with clinical diagnosis of viral hepatitis. PLoS One 11: e0148417.
-
25.
Purdy MA, Dell’Amico MC, Gonzales JL, Segundo H, Tolari F, Mazzei M, Bartoloni A, Khudyakov YE, 2012. Human and porcine hepatitis E viruses, southeastern Bolivia. Emerg Infect Dis 18: 339–340.
-
26.
Glynn MK, Friedman CR, Gold BD, Khanna B, Hutwagner L, Iihoshi N, Revollo C, Quick R, 2002. Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: acquisition and analysis of possible risk factors. Clin Infect Dis 35: 1059–1065.
-
27.
Santos IS et al. 2009. Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela. Public Health Nutr 12: 1862–1870.
-
28.
Sivapalasingam S, Rajasingham A, Macy JT, Friedman CR, Hoekstra RM, Ayers T, Gold B, Quick RE, 2014. Recurrence of Helicobacter pylori infection in Bolivian children and adults after a population-based ‘screen and treat’ strategy. Helicobacter 19: 343–348.
-
29.
Miftahussurur M, Yamaoka Y, 2016. Diagnostic methods of Helicobacter pylori infection for epidemiological studies: critical importance of indirect test validation. Biomed Res Int 2016: 4819423.
-
30.
Sierra MS, Cueva P, Bravo LE, Forman D, 2016. Stomach cancer burden in central and south America. Cancer Epidemiol 44: S62–S73.
-
31.
Macchioni F, Segundo H, Gabrielli S, Totino V, Gonzales PR, Salazar E, Bozo R, Bartoloni A, Cancrini G, 2015. Dramatic decrease in prevalence of soil-transmitted helminthiasis and new insight into intestinal protozoa in children living in the Chaco region, Bolivia. Am J Trop Med Hyg 92 (Suppl 4): 794–796.
-
32.
Macchioni F, Segundo H, Totino V, Gabrielli S, Rojas P, Roselli M, Paredes GA, Masana M, Bartoloni A, Cancrini G, 2016. Intestinal parasitic infections and associated epidemiological drivers in two rural communities of the Bolivian Chaco. J Infect Dev Ctries 10: 1012–1019.
-
33.
WHO, 2015. Water Sanitation and Hygiene 2015–2020: A Global Strategy for Accelerating and Sustaining Progress on Neglected Tropical Diseases. Geneva, Switzerland: World Health Organization.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 411 | 324 | 75 |
| Full Text Views | 800 | 7 | 0 |
| PDF Downloads | 134 | 9 | 0 |