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To evaluate potential immunocompetent small animal models of Zika virus (ZIKV) infection, we inoculated Syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with Senegalese ZIKV strain ArD 41525 or Philippines ZIKV strain CPC-0740. We did not detect viremia in hamsters inoculated subcutaneously with either virus strain, although some hamsters developed virus neutralizing antibodies. However, we detected statistically significant higher viremias (P = 0.0285) and a higher median neutralization titer (P = 0.0163) in hamsters inoculated intraperitoneally with strain ArD 41525 compared with strain CPC-0740. Furthermore, some hamsters inoculated with strain ArD 41525 displayed mild signs of disease. By contrast, strain 13 guinea pigs inoculated intraperitoneally with either strain did not have detectable viremias and less than half developed virus neutralizing antibodies. Our results support the use of the Syrian golden hamster intraperitoneal model to explore phenotypic variation between ZIKV strains.
Financial support: This work was supported by a grant from The Defense Advanced Research Projects Agency (DARPA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this article are those of the authors and do not reflect the official policy or position of the U.S. Department of Defense or the Department of the Army.
Authors’ addresses: Lynn J. Miller and Luis A. Lugo-Roman, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, MD, E-mails: email@example.com and firstname.lastname@example.org. Farooq Nasar, Adrienne E. Kimmel, Stephanie M. Valdez, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Thomas R. Sprague, Sina Bavari, M. Louise M. Pitt, and Andrew D. Haddow, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, MD, E-mails: email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, and email@example.com. Christopher W. Schellhase, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Pathology Division, Fort Detrick, MD, E-mail: firstname.lastname@example.org. Sarah L. Norris, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Biostatistics Division, Fort Detrick, MD, E-mail: email@example.com. Richard G. Jarman, Walter Reed Army Institute of Research, Virology Division, Silver Spring, MD, E-mail: firstname.lastname@example.org. In-Kyu Yoon, International Vaccine Institute (IVI), Seoul, Republic of Korea, E-mail: InKyu.Yoon@IVI.INT. Maria T. Alera, Philippines-AFRIMS Virology Research Unit (PARVU), Cebu City, Philippines, E-mail: MariaTheresa.Alera.email@example.com.