Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Haddow AD, Nasar F, Guzman H, Ponlawat A, Jarman RG, Tesh RB, Weaver SC, 2016. Genetic characterization of Spondweni and Zika viruses and susceptibility of geographically distinct strains of Aedes aegypti, Aedes albopictus and Culex quinquefasciatus (Diptera: Culicidae) to Spondweni virus. PLoS Negl Trop Dis 10: e0005083.
-
2.
Dick GW, Kitchen SF, Haddow AJ, 1952. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 46: 509–520.
-
3.
Haddow AJ, Williams MC, Woodall JP, Simpson DI, Goma LK, 1964. Twelve isolations of Zika virus from Aedes (Stegomyia) africanus (Theobald) taken in and above a Uganda forest. Bull World Health Organ 31: 57–69.
-
4.
Haddow AD et al.., 2017. High infection rates for adult Macaques after intravaginal or intrarectal inoculation with Zika virus. Emerg Infect Dis 23: 1274–1281.
-
5.
Duggal NK, Ritter JM, Pestorius SE, Zaki SR, Davis BS, Chang GJ, Bowen RA, Brault AC, 2017. Frequent Zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model. Cell Reports 18: 1751–1760.
-
6.
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, Lanciotti RS, Tesh RB, 2011. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 17: 880–882.
-
7.
Aliota MT et al.., 2017. Zika in the Americas, year 2: what have we learned? What gaps remain? A report from the global virus network. Antiviral Res 144: 223–246.
-
8.
Haddow AD, Woodall JP, 2016. Distinguishing between Zika and Spondweni viruses. B Bull World Health Organ 94: 711.
-
9.
Morrison TE, Diamond MS, 2017. Animal models of Zika virus infection, pathogenesis, and immunity. J Virol 91: e00009–e00017.
-
10.
Brault AC, Bowen RA, 2016. The development of small animal models for Zika virus vaccine efficacy testing and pathological assessment. Am J Trop Med Hyg 94: 1187–1188.
-
11.
Adler S, 1948. Origin of the golden hamster Cricetus auratus as a laboratory animal. Nature 162: 256.
-
12.
Clark DC, Brault AC, Hunsperger E, 2012. The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system. Arch Virol 157: 1423–1440.
-
13.
Gowen BB, Holbrook MR, 2008. Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses. Antiviral Res 78: 79–90.
-
14.
Wright S, 1922. The effects of inbreeding and crossbreeding on guinea pigs. II. Differentiation among inbred families. Bull. U.S. Dep. Agric.,1090: 37–63.
-
15.
Safronetz D, Geisbert TW, Feldmann H, 2013. Animal models for highly pathogenic emerging viruses. Curr Opin Virol 3: 205–209.
-
16.
Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, Guzman H, Tesh RB, Weaver SC, 2012. Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis 6: e1477.
-
17.
Ladner JT et al.., 2016. Complete genome sequences of five Zika virus isolates. Genome Announc 4: e00377-16.
-
18.
Ellison DW et al.., 2016. Complete genome sequences of Zika virus strains isolated from the blood of patients in Thailand in 2014 and the Philippines in 2012. Genome Announc 4: e00359-16.
-
19.
Shek J, Smith A, Pritchett-Corning K, 2015. Microbiological quality control for laboratory rodents and lagomorphs. Fox J, Anderson L, Otto G, Pritchett-Corning K, Whary, M, eds. Laboratory Animal Medicine, 3rd edition. Oxford, UK: Elsevier, 463–499.
-
20.
Guerbois M et al.., 2016. Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by Aedes aegypti mosquitoes in the Americas. J Infect Dis 214: 1349–1356.
-
21.
Prophet EB, Mills B, Arrignton JB, Sobin LH, 1992. Laboratory Methods for Histotechnology. Washington, DC: Armed Forces Institute of Pathology.
-
22.
Ragan IK, Blizzard EL, Gordy P, Bowen RA, 2017. Investigating the potential role of North American animals as hosts for Zika virus. Vector Borne Zoonotic Dis 17: 161–164.
-
23.
Weger-Lucarelli J, 2016. Vector competence of American mosquitoes for three strains of Zika virus. PLoS Negl Trop Dis 10: e0005101.
-
24.
Bowen JR, Quicke KM, Maddur MS, O’Neal JT, McDonald CE, Fedorova NB, Puri V, Shabman RS, Pulendran B, Suthar MS, 2017. Zika virus antagonizes type I interferon responses during infection of human dendritic cells. PLoS Pathog 13: e1006164.
-
25.
Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, Diamond MS, 2016. A mouse model of Zika virus pathogenesis. Cell Host Microbe 19: 720–730.
-
26.
Roundy CM et al.., 2017. Variation in Aedes aegypti mosquito competence for Zika virus transmission. Emerg Infect Dis 23: 625–632.
-
27.
Duggal NK, Ritter JM, McDonald EM, Romo H, Guirakhoo F, Davis BS, Chang GJ, Brault AC, 2017. Differential neurovirulence of African and Asian genotype Zika virus isolates in outbred immunocompetent mice. Am J Trop Med Hyg 97: 1410–1417.
-
28.
Dick GW, 1952. Zika virus. II. Pathogenicity and physical properties. Trans R Soc Trop Med Hyg 46: 521–534.
-
29.
Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR, 2017. A guinea pig model of Zika virus infection. Virol J 14: 75.
-
30.
Geczy AF, de Weck AL, Schwartz BD, Shevach EM, 1975. The major histocompatibility complex of the guinea pig. I. Serologic and genetic studies. J Immunol 115: 1704–1710.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1409 | 1250 | 318 |
| Full Text Views | 599 | 10 | 0 |
| PDF Downloads | 135 | 13 | 2 |
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs
Lynn J. Miller
Lynn J. Miller
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, Maryland;
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Farooq Nasar
Farooq Nasar
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Christopher W. Schellhase
Christopher W. Schellhase
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Pathology Division, Fort Detrick, Maryland;
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Sarah L. Norris
Sarah L. Norris
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Biostatistics Division, Fort Detrick, Maryland;
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Adrienne E. Kimmel
Adrienne E. Kimmel
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Stephanie M. Valdez
Stephanie M. Valdez
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Suzanne E. Wollen-Roberts
Suzanne E. Wollen-Roberts
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Joshua D. Shamblin
Joshua D. Shamblin
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Thomas R. Sprague
Thomas R. Sprague
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Luis A. Lugo-Roman
Luis A. Lugo-Roman
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, Maryland;
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Richard G. Jarman
Richard G. Jarman
Walter Reed Army Institute of Research, Virology Division, Silver Spring, Maryland;
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In-Kyu Yoon
In-Kyu Yoon
International Vaccine Institute (IVI), Seoul, Republic of Korea;
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Maria T. Alera
Maria T. Alera
Philippines-AFRIMS Virology Research Unit (PARVU), Cebu City, Philippines
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Sina Bavari
Sina Bavari
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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M. Louise M. Pitt
M. Louise M. Pitt
United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland;
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Andrew D. Haddow
Andrew D. Haddow
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To evaluate potential immunocompetent small animal models of Zika virus (ZIKV) infection, we inoculated Syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with Senegalese ZIKV strain ArD 41525 or Philippines ZIKV strain CPC-0740. We did not detect viremia in hamsters inoculated subcutaneously with either virus strain, although some hamsters developed virus neutralizing antibodies. However, we detected statistically significant higher viremias (P = 0.0285) and a higher median neutralization titer (P = 0.0163) in hamsters inoculated intraperitoneally with strain ArD 41525 compared with strain CPC-0740. Furthermore, some hamsters inoculated with strain ArD 41525 displayed mild signs of disease. By contrast, strain 13 guinea pigs inoculated intraperitoneally with either strain did not have detectable viremias and less than half developed virus neutralizing antibodies. Our results support the use of the Syrian golden hamster intraperitoneal model to explore phenotypic variation between ZIKV strains.
Author Notes
Financial support: This work was supported by a grant from The Defense Advanced Research Projects Agency (DARPA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this article are those of the authors and do not reflect the official policy or position of the U.S. Department of Defense or the Department of the Army.
Authors’ addresses: Lynn J. Miller and Luis A. Lugo-Roman, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, MD, E-mails: ynn.j.miller.mil@mail.mil and luis.a.lugoroman.mil@mail.mil. Farooq Nasar, Adrienne E. Kimmel, Stephanie M. Valdez, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Thomas R. Sprague, Sina Bavari, M. Louise M. Pitt, and Andrew D. Haddow, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, MD, E-mails: farooq.nasar.ctr@mail.mil, adrienne.e.kimmel.ctr@mail.mil, stephanie.m.valdez5.ctr@mail.mil, suzanne.e.wollen.ctr@mail.mil, joshua.d.shamblin1.civ@mail.mil, thomas.r.sprague7.ctr@mail.mil, sina.bavari.civ@mail.mil, margaret.l.pitt.civ@mail.mil, and andrew.d.haddow.ctr@mail.mil. Christopher W. Schellhase, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Pathology Division, Fort Detrick, MD, E-mail: christopher.w.schellhase.mil@mail.mil. Sarah L. Norris, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Biostatistics Division, Fort Detrick, MD, E-mail: sarah.l.norris2.civ@mail.mil. Richard G. Jarman, Walter Reed Army Institute of Research, Virology Division, Silver Spring, MD, E-mail: richard.g.jarman.mil@mail.mil. In-Kyu Yoon, International Vaccine Institute (IVI), Seoul, Republic of Korea, E-mail: InKyu.Yoon@IVI.INT. Maria T. Alera, Philippines-AFRIMS Virology Research Unit (PARVU), Cebu City, Philippines, E-mail: MariaTheresa.Alera.ca@afrims.org.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Haddow AD, Nasar F, Guzman H, Ponlawat A, Jarman RG, Tesh RB, Weaver SC, 2016. Genetic characterization of Spondweni and Zika viruses and susceptibility of geographically distinct strains of Aedes aegypti, Aedes albopictus and Culex quinquefasciatus (Diptera: Culicidae) to Spondweni virus. PLoS Negl Trop Dis 10: e0005083.
-
2.
Dick GW, Kitchen SF, Haddow AJ, 1952. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 46: 509–520.
-
3.
Haddow AJ, Williams MC, Woodall JP, Simpson DI, Goma LK, 1964. Twelve isolations of Zika virus from Aedes (Stegomyia) africanus (Theobald) taken in and above a Uganda forest. Bull World Health Organ 31: 57–69.
-
4.
Haddow AD et al.., 2017. High infection rates for adult Macaques after intravaginal or intrarectal inoculation with Zika virus. Emerg Infect Dis 23: 1274–1281.
-
5.
Duggal NK, Ritter JM, Pestorius SE, Zaki SR, Davis BS, Chang GJ, Bowen RA, Brault AC, 2017. Frequent Zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model. Cell Reports 18: 1751–1760.
-
6.
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, Lanciotti RS, Tesh RB, 2011. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 17: 880–882.
-
7.
Aliota MT et al.., 2017. Zika in the Americas, year 2: what have we learned? What gaps remain? A report from the global virus network. Antiviral Res 144: 223–246.
-
8.
Haddow AD, Woodall JP, 2016. Distinguishing between Zika and Spondweni viruses. B Bull World Health Organ 94: 711.
-
9.
Morrison TE, Diamond MS, 2017. Animal models of Zika virus infection, pathogenesis, and immunity. J Virol 91: e00009–e00017.
-
10.
Brault AC, Bowen RA, 2016. The development of small animal models for Zika virus vaccine efficacy testing and pathological assessment. Am J Trop Med Hyg 94: 1187–1188.
-
11.
Adler S, 1948. Origin of the golden hamster Cricetus auratus as a laboratory animal. Nature 162: 256.
-
12.
Clark DC, Brault AC, Hunsperger E, 2012. The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system. Arch Virol 157: 1423–1440.
-
13.
Gowen BB, Holbrook MR, 2008. Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses. Antiviral Res 78: 79–90.
-
14.
Wright S, 1922. The effects of inbreeding and crossbreeding on guinea pigs. II. Differentiation among inbred families. Bull. U.S. Dep. Agric.,1090: 37–63.
-
15.
Safronetz D, Geisbert TW, Feldmann H, 2013. Animal models for highly pathogenic emerging viruses. Curr Opin Virol 3: 205–209.
-
16.
Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, Guzman H, Tesh RB, Weaver SC, 2012. Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis 6: e1477.
-
17.
Ladner JT et al.., 2016. Complete genome sequences of five Zika virus isolates. Genome Announc 4: e00377-16.
-
18.
Ellison DW et al.., 2016. Complete genome sequences of Zika virus strains isolated from the blood of patients in Thailand in 2014 and the Philippines in 2012. Genome Announc 4: e00359-16.
-
19.
Shek J, Smith A, Pritchett-Corning K, 2015. Microbiological quality control for laboratory rodents and lagomorphs. Fox J, Anderson L, Otto G, Pritchett-Corning K, Whary, M, eds. Laboratory Animal Medicine, 3rd edition. Oxford, UK: Elsevier, 463–499.
-
20.
Guerbois M et al.., 2016. Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by Aedes aegypti mosquitoes in the Americas. J Infect Dis 214: 1349–1356.
-
21.
Prophet EB, Mills B, Arrignton JB, Sobin LH, 1992. Laboratory Methods for Histotechnology. Washington, DC: Armed Forces Institute of Pathology.
-
22.
Ragan IK, Blizzard EL, Gordy P, Bowen RA, 2017. Investigating the potential role of North American animals as hosts for Zika virus. Vector Borne Zoonotic Dis 17: 161–164.
-
23.
Weger-Lucarelli J, 2016. Vector competence of American mosquitoes for three strains of Zika virus. PLoS Negl Trop Dis 10: e0005101.
-
24.
Bowen JR, Quicke KM, Maddur MS, O’Neal JT, McDonald CE, Fedorova NB, Puri V, Shabman RS, Pulendran B, Suthar MS, 2017. Zika virus antagonizes type I interferon responses during infection of human dendritic cells. PLoS Pathog 13: e1006164.
-
25.
Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, Diamond MS, 2016. A mouse model of Zika virus pathogenesis. Cell Host Microbe 19: 720–730.
-
26.
Roundy CM et al.., 2017. Variation in Aedes aegypti mosquito competence for Zika virus transmission. Emerg Infect Dis 23: 625–632.
-
27.
Duggal NK, Ritter JM, McDonald EM, Romo H, Guirakhoo F, Davis BS, Chang GJ, Brault AC, 2017. Differential neurovirulence of African and Asian genotype Zika virus isolates in outbred immunocompetent mice. Am J Trop Med Hyg 97: 1410–1417.
-
28.
Dick GW, 1952. Zika virus. II. Pathogenicity and physical properties. Trans R Soc Trop Med Hyg 46: 521–534.
-
29.
Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR, 2017. A guinea pig model of Zika virus infection. Virol J 14: 75.
-
30.
Geczy AF, de Weck AL, Schwartz BD, Shevach EM, 1975. The major histocompatibility complex of the guinea pig. I. Serologic and genetic studies. J Immunol 115: 1704–1710.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1409 | 1250 | 318 |
| Full Text Views | 599 | 10 | 0 |
| PDF Downloads | 135 | 13 | 2 |