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-
1.
Elston JW, Moosa AJ, Moses F, Walker G, Dotta N, Waldman RJ, Wright J, 2016. Impact of the Ebola outbreak on health systems and population health in Sierra Leone. J Public Health (Oxf) 38: 673–678.
-
2.
Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR, 2016. Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. Int J Epidemiol 45: 102–116.
-
3.
Pellecchia U, 2015. Do Traditions Spread Ebola? Available at: http://www.ebola-anthropology.net/case_studies/do-traditions-spread-ebola/. Accessed January 4, 2017.
-
4.
Thomas LV, 1986. La vieillesse en Afrique noire: transmission orale et rarete individuelle. Quebec: Universite du Quebec a Chicoutimi, Departement des sciences humaines.
-
5.
Fairhead JRP, 2014. Ebola and Older People in Sierra Leone, Liberia and Guinea. Available at: http://www.ebola-anthropology.net/key_messages/ebola-and-older-people-in-sierra-leone-liberia-and-guinea/. Accessed June 30, 2017.
-
6.
WHO, 2014. Case Definition Recommendations for Ebola or Marburg Virus Diseases. Geneva, Switzerland: World Health Organization.
-
7.
Rico A et al. 2016. Epidemiology of epidemic Ebola virus disease in Conakry and surrounding prefectures, Guinea, 2014–2015. Emerg Infect Dis 22: 178–183.
-
8.
WHO, 2002. Definition of an Older or Elderly Person: Proposed Working Definition of an Older Person in Africa for the MDS Project. WHO Health statistics and information systems. Geneva, Switzerland: World Health Organization.
-
9.
Bower H, Johnson S, Bangura MS, Kamara AJ, Kamara O, Mansaray SH, Sesay D, Turay C, Checchi F, Glynn JR, 2016. Exposure-specific and age-specific attack rates for Ebola virus disease in Ebola-affected households, Sierra Leone. Emerg Infect Dis 22: 1403–1411.
-
10.
Hartley MA, Young A, Tran AM, Okoni-Williams HH, Suma M, Mancuso B, Al-Dikhari A, Faouzi M, 2017. Predicting Ebola severity: a clinical prioritization score for Ebola virus disease. PLoS Negl Trop Dis 11: e0005265.
-
11.
Pisani MA, 2009. Considerations in caring for the critically ill older patient. J Intensive Care Med 24: 83–95.
-
12.
Marik PE, 2006. Management of the critically ill geriatric patient. Crit Care Med 34: S176–S182.
-
13.
Leligdowicz A et al. 2016. Ebola virus disease and critical illness. Crit Care 20: 217.
-
14.
Fitzpatrick G, Vogt F, Moi Gbabai OB, Decroo T, Keane M, De Clerck H, Grolla A, Brechard R, Stinson K, Van Herp M, 2015. The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Medecins Sans Frontieres Ebola Case Management Centre, Kailahun, Sierra Leone, June–October 2014. J Infect Dis 212: 1752–1758.
-
15.
WHO, 2015. Guinea: The Ebola Virus Shows Its Tenacity: One Year into the Ebola Epidemic. Emergencies preparedness, response. Geneva, Switzerland: World Health Organization.
-
16.
Wilkinson A, Fairhead J, 2017. Comparison of social resistance to Ebola response in Sierra Leone and Guinea suggests explanations lie in political configurations not culture. Crit Public Health 27: 14–27.
-
17.
Carrion Martin AI, Derrough T, Honomou P, Kolie N, Diallo B, Kone M, Rodier G, Kpoghomou C, Jansa JM, 2016. Social and cultural factors behind community resistance during an Ebola outbreak in a village of the Guinean Forest region, February 2015: a field experience. Int Health 8: 227–229.
-
18.
Manguvo A, Mafuvadze B, 2015. The impact of traditional and religious practices on the spread of Ebola in West Africa: time for a strategic shift. Pan Afr Med J 22 (Suppl 1): 9.
-
19.
Ji YJ et al. 2016. Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone. Infect Dis Poverty 5: 101.
-
20.
Yan T et al. 2015. Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak. Eur J Clin Microbiol Infect Dis 34: 2089–2095.
-
21.
Cherif MS, Koonrungsesomboon N, Diallo MP, Le Gall E, Kasse D, Cherif F, Kone A, Diakite M, Camara F, Magassouba N, 2017. The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014–2015 outbreak in Guinea. Eur J Clin Microbiol Infect Dis 36: 689–695.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 866 | 659 | 16 |
| Full Text Views | 613 | 10 | 4 |
| PDF Downloads | 124 | 7 | 2 |
Prognostic and Predictive Factors of Ebola Virus Disease Outcome in Elderly People during the 2014 Outbreak in Guinea
Mahamoud Sama Cherif
Mahamoud Sama Cherif
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan;
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Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan;
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Shyam Prakash Dumre
Shyam Prakash Dumre
Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan;
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Diénaba Kassé
Diénaba Kassé
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Fatoumata Cherif
Fatoumata Cherif
Ministry of Health and Public Hygiene, Conakry, Guinea;
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Facely Camara
Facely Camara
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Alpha Koné
Alpha Koné
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Mandiou Diakité
Mandiou Diakité
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Mohamed Cissé
Mohamed Cissé
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Mamadou Pathé Diallo
Mamadou Pathé Diallo
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
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Edouard Le Gall
Edouard Le Gall
Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea;
Pôle Régional de Cancérologie Bretagne, Rennes, France
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Pôle Régional de Cancérologie Bretagne, Rennes, France
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Juntra Karbwang
Juntra Karbwang
Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan;
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Kenji Hirayama
Kenji Hirayama
Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan;
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Elderly people occupy a prominent position in African societies; however, their potential linkage to high case fatality rate (CFR) in Ebola virus disease (EVD) was often overlooked. We describe the predictive factors for EVD lethality in the elderly. A total of 2,004 adults and 309 elderly patients with confirmed EVD were included in the analysis. The median age (interquartile range) was 35 years (23–44) in adults and 65 years (60–70) in the elderly. The proportion of funeral participation was significantly higher in the elderly group than in the adult group. Duration (in days) between the onset of symptoms and admission was significantly longer in elderly. CFR in the elderly people was also significantly higher (80.6%) than in the adult group (66.2%). Funeral participation constituted a risk factor for the transmission of EVD in elderly people.
Author Notes
Authors’ addresses: Mahamoud Sama Cherif, Department of Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan, and Department of Medecine, Universite Gamal Abdel Nasser de Conakry, Commune de Dixinn, Conakry, Guinea, E-mail: msamafr@gmail.com. Shyam Prakash Dumre and Kenji Hirayama, Department of Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan, E-mails: sp.dumre@gmail.com and hiraken@nagasaki-u.ac.jp. Diénaba Kassé, Facely Camara, Alpha Koné, Mandiou Diakité, Mohamed Cissé, and Mamadou Pathé Diallo, Department of Medecine, Universite Gamal Abdel Nasser de Conakry, Conakry, Guinea, E-mails: dienabak@yahoo.fr, facelyfr@yahoo.fr, alafekone@gmail.com, mandioud@yahoo.fr, cissebibi1@gmail.com, and bapathediallo@yahoo.fr. Fatoumata Cherif, Ministry of Health and Public Hygiene, Agence Nationale de Sécurité Sanitaire, Conakry, Guinea, E-mail: fatoumatacherif82@yahoo.fr. Edouard Le Gall, Pôle Régional de Cancérologie Bretagne, Rennes, Rennes, France, and Department of Medecine, Universite Gamal Abdel Nasser de Conakry, Conakry, Guinea, E-mail: edouard.le.gall@chu-rennes.fr. Juntra karbwang, Department of Product Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan, E-mail: karbwangj@nagasaki-u.ac.jp.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Elston JW, Moosa AJ, Moses F, Walker G, Dotta N, Waldman RJ, Wright J, 2016. Impact of the Ebola outbreak on health systems and population health in Sierra Leone. J Public Health (Oxf) 38: 673–678.
-
2.
Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR, 2016. Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. Int J Epidemiol 45: 102–116.
-
3.
Pellecchia U, 2015. Do Traditions Spread Ebola? Available at: http://www.ebola-anthropology.net/case_studies/do-traditions-spread-ebola/. Accessed January 4, 2017.
-
4.
Thomas LV, 1986. La vieillesse en Afrique noire: transmission orale et rarete individuelle. Quebec: Universite du Quebec a Chicoutimi, Departement des sciences humaines.
-
5.
Fairhead JRP, 2014. Ebola and Older People in Sierra Leone, Liberia and Guinea. Available at: http://www.ebola-anthropology.net/key_messages/ebola-and-older-people-in-sierra-leone-liberia-and-guinea/. Accessed June 30, 2017.
-
6.
WHO, 2014. Case Definition Recommendations for Ebola or Marburg Virus Diseases. Geneva, Switzerland: World Health Organization.
-
7.
Rico A et al. 2016. Epidemiology of epidemic Ebola virus disease in Conakry and surrounding prefectures, Guinea, 2014–2015. Emerg Infect Dis 22: 178–183.
-
8.
WHO, 2002. Definition of an Older or Elderly Person: Proposed Working Definition of an Older Person in Africa for the MDS Project. WHO Health statistics and information systems. Geneva, Switzerland: World Health Organization.
-
9.
Bower H, Johnson S, Bangura MS, Kamara AJ, Kamara O, Mansaray SH, Sesay D, Turay C, Checchi F, Glynn JR, 2016. Exposure-specific and age-specific attack rates for Ebola virus disease in Ebola-affected households, Sierra Leone. Emerg Infect Dis 22: 1403–1411.
-
10.
Hartley MA, Young A, Tran AM, Okoni-Williams HH, Suma M, Mancuso B, Al-Dikhari A, Faouzi M, 2017. Predicting Ebola severity: a clinical prioritization score for Ebola virus disease. PLoS Negl Trop Dis 11: e0005265.
-
11.
Pisani MA, 2009. Considerations in caring for the critically ill older patient. J Intensive Care Med 24: 83–95.
-
12.
Marik PE, 2006. Management of the critically ill geriatric patient. Crit Care Med 34: S176–S182.
-
13.
Leligdowicz A et al. 2016. Ebola virus disease and critical illness. Crit Care 20: 217.
-
14.
Fitzpatrick G, Vogt F, Moi Gbabai OB, Decroo T, Keane M, De Clerck H, Grolla A, Brechard R, Stinson K, Van Herp M, 2015. The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Medecins Sans Frontieres Ebola Case Management Centre, Kailahun, Sierra Leone, June–October 2014. J Infect Dis 212: 1752–1758.
-
15.
WHO, 2015. Guinea: The Ebola Virus Shows Its Tenacity: One Year into the Ebola Epidemic. Emergencies preparedness, response. Geneva, Switzerland: World Health Organization.
-
16.
Wilkinson A, Fairhead J, 2017. Comparison of social resistance to Ebola response in Sierra Leone and Guinea suggests explanations lie in political configurations not culture. Crit Public Health 27: 14–27.
-
17.
Carrion Martin AI, Derrough T, Honomou P, Kolie N, Diallo B, Kone M, Rodier G, Kpoghomou C, Jansa JM, 2016. Social and cultural factors behind community resistance during an Ebola outbreak in a village of the Guinean Forest region, February 2015: a field experience. Int Health 8: 227–229.
-
18.
Manguvo A, Mafuvadze B, 2015. The impact of traditional and religious practices on the spread of Ebola in West Africa: time for a strategic shift. Pan Afr Med J 22 (Suppl 1): 9.
-
19.
Ji YJ et al. 2016. Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone. Infect Dis Poverty 5: 101.
-
20.
Yan T et al. 2015. Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak. Eur J Clin Microbiol Infect Dis 34: 2089–2095.
-
21.
Cherif MS, Koonrungsesomboon N, Diallo MP, Le Gall E, Kasse D, Cherif F, Kone A, Diakite M, Camara F, Magassouba N, 2017. The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014–2015 outbreak in Guinea. Eur J Clin Microbiol Infect Dis 36: 689–695.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 866 | 659 | 16 |
| Full Text Views | 613 | 10 | 4 |
| PDF Downloads | 124 | 7 | 2 |