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-
1.
Gonzalez AE, Gilman R, Garcia HH, McDonald J, Kacena K, Tsang VC, Pilcher JB, Suarez F, Gavidia C, Miranda E, 1994. Use of sentinel pigs to monitor environmental Taenia solium contamination. The Cysticercosis Working Group in Peru (CWG). Am J Trop Med Hyg 51: 847–850.
-
2.
García HH et al. Cysticercosis Working Group in Perú, 2003. Hyperendemic human and porcine Taenia solium infection in Perú. Am J Trop Med Hyg 68: 268–275.
-
3.
O’Neal SE, Moyano LM, Ayvar V, Rodriguez S, Gavidia C, Wilkins PP, Gilman RH, Garcia HH, Gonzalez AE; Cysticercosis Working Group in Peru, 2014. Ring-screening to control endemic transmission of Taenia solium. PLoS Negl Trop Dis 8: e3125.
-
4.
Gavidia CM, Verastegui MR, Garcia HH, Lopez-Urbina T, Tsang VC, Pan W, Gilman RH, Gonzalez AE; Cysticercosis Working Group in Peru, 2013. Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis 7: e2192.
-
5.
Mohan VR, Tharmalingam J, Muliyil J, Oommen A, Dorny P, Vercruysse J, Vedantam R, 2013. Prevalence of porcine cysticercosis in Vellore, South India. Trans R Soc Trop Med Hyg 107: 62–64.
-
6.
Sikasunge CS, Phiri IK, Phiri AM, Siziya S, Dorny P & Willingham AL 3 rd, 2008. Prevalence of Taenia solium porcine cysticercosis in the eastern, southern and western provinces of Zambia. Vet J 176: 240–244.
-
7.
Tsang VC, Brand JA, Boyer AE, 1989. An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis (Taenia solium). J Infect Dis 159: 50–59.
-
8.
Tsang VC, Pilcher JA, Zhou W, Boyer AE, Kamango-Sollo EI, Rhoads ML, Murrell KD, Schantz PM, Gilman RH, 1991. Efficacy of the immunoblot assay for cysticercosis in pigs and modulated expression of distinct IgM/IgG activities to Taenia solium antigens in experimental infections. Vet Immunol Immunopathol 29: 69–78.
-
9.
Garcia HH et al. 2016. Elimination of Taenia solium transmission in northern Peru. N Engl J Med 374: 2335–2344.
-
10.
Brandt JR, Geerts S, De Deken R, Kumar V, Ceulemans F, Brijs L, Falla N, 1992. A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis. Int J Parasitol 22: 471–477.
-
11.
Nguekam A, Zoli AP, Vondou L, Pouedet SM, Assana E, Dorny P, Brandt J, Losson B, Geerts S, 2003. Kinetics of circulating antigens in pigs experimentally infected with Taenia solium eggs. Vet Parasitol 111: 323–332.
-
12.
Guezala MC, Rodriguez S, Zamora H, Garcia HH, Gonzalez AE, Tembo A, Allan JC, Craig PS, 2013. Development of a species-specific coproantigen ELISA for human Taenia solium taeniasis. Am J Trop Med Hyg 81: 433–437.
-
13.
Gemmell MA, 1973. Surveillance of Echinococcus granulosus in dogs with arecoline hydrobromide. Bull World Health Organ 48: 649–652.
-
14.
Liu GH, Lin RQ, Li MW, Liu W, Liu Y, Yuan ZG, Song HQ, Zhao GH, Zhang KX, Zhu XQ, 2011. The complete mitochondrial genomes of three cestode species of Taenia infecting animals and humans. Mol Biol Rep 38: 2249–2256.
-
15.
Bowles J, McManus DP, 1994. Genetic characterization of the Asian Taenia, a newly described taeniid cestode of humans. Am J Trop Med Hyg 50: 33–44.
-
16.
Zhan G, Chen J, Yang Y, Liu N, Jiang W, Gu S, Wang X, Wang Z, 2014. Utility of DNA barcoding in distinguishing species of the family Taeniidae. J Parasitol 100: 542–546.
-
17.
Dorny P, Phiri IK, Vercruysse J, Gabriel S, Willingham AL 3rd, Brandt J, Victor B, Speybroeck N, Berkvens D, 2004. A Bayesian approach for estimating values for prevalence and diagnostic test characteristics of porcine cysticercosis. Int J Parasitol 34: 569–576.
-
18.
Cheng RWK, Ko R, 1991. Cross-reactions between crude antigens of larval Taenia solium (Cysticercus cellulosae) and other helminths of pigs. Vet Parasitol 39: 161–170.
-
19.
Nguyen MT, Gabriël S, Abatih EN, Dorny P, 2016. A systematic review on the global occurrence of Taenia hydatigena in pigs and cattle. Vet Parasitol 226: 97–103.
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Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay
Claudio Muro
Claudio Muro
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
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Luis A. Gomez-Puerta
Luis A. Gomez-Puerta
School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru;
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Robert H. Flecker
Robert H. Flecker
School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon;
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Ricardo Gamboa
Ricardo Gamboa
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
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Percy Vilchez Barreto
Percy Vilchez Barreto
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
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Pierre Dorny
Pierre Dorny
Institute of Tropical Medicine, Antwerp, Belgium;
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Victor C. W. Tsang
Victor C. W. Tsang
Georgia State University, Atlanta, Georgia;
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Robert H. Gilman
Robert H. Gilman
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland;
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Armando E. Gonzalez
Armando E. Gonzalez
School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru;
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Hector H. Garcia
Hector H. Garcia
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
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Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
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Seth E. O’Neal
Seth E. O’Neal
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon;
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School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon;
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for the Cysticercosis Working Group in Peru
for the Cysticercosis Working Group in Peru
Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru;
School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru;
School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon;
Institute of Tropical Medicine, Antwerp, Belgium;
Georgia State University, Atlanta, Georgia;
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland;
Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
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School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru;
School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon;
Institute of Tropical Medicine, Antwerp, Belgium;
Georgia State University, Atlanta, Georgia;
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland;
Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
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The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6–8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigena metacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 cross-reactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.
Author Notes
Financial support: This research was made possible with support from the Fogarty International Center (FIC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) grant number R21AI119438. Partial support from Training grant TW001140 from the Fogarty International Center in training of study team members is also acknowledged.
Authors’ addresses: Claudio Muro and Ricardo Gamboa, Centro de Salud Global Tumbes, Universidad Peruana Cayetano Heredia, Lima, Perú, E-mails: claudio.muro@peruresearch.org and rgamboa@peruresearch.org. Luis A. Gomez-Puerta, Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, Lima, Peru, E-mail: lucho92@yahoo.com. Robert H. Flecker, Department of Epidemiology, School of Public Health, Oregon Health & Science University and Portland State University, Portland, OR, E-mail: flecker@ohsu.edu. Percy Vilchez Barreto, Centro de Salud Global UPCH, Tumbes, Peru, E-mail: pvilchez@peruresearch.org. Pierre Dorny, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium, E-mail: pdorny@itg.be. Victor C. W. Tsang, Georgia State University, Atlanta, GA, E-mail: vct123@gmail.com. Robert H. Gilman, Department of International Health, Johns Hopkins University, Baltimore, MD, E-mail: gilmanbob@gmail.com. Armando E. Gonzalez, School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru, E-mail: agonza41@jhu.edu. Hector H. Garcia, Centro de Salud Global Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru and Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: hgarcia1@jhu.edu. Seth E. O’Neal, Department of Epidemiology, School of Public Health, Oregon Health & Science University and Portland State University, Portland, OR and Center for Global Health - Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: oneals@ohsu.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Gonzalez AE, Gilman R, Garcia HH, McDonald J, Kacena K, Tsang VC, Pilcher JB, Suarez F, Gavidia C, Miranda E, 1994. Use of sentinel pigs to monitor environmental Taenia solium contamination. The Cysticercosis Working Group in Peru (CWG). Am J Trop Med Hyg 51: 847–850.
-
2.
García HH et al. Cysticercosis Working Group in Perú, 2003. Hyperendemic human and porcine Taenia solium infection in Perú. Am J Trop Med Hyg 68: 268–275.
-
3.
O’Neal SE, Moyano LM, Ayvar V, Rodriguez S, Gavidia C, Wilkins PP, Gilman RH, Garcia HH, Gonzalez AE; Cysticercosis Working Group in Peru, 2014. Ring-screening to control endemic transmission of Taenia solium. PLoS Negl Trop Dis 8: e3125.
-
4.
Gavidia CM, Verastegui MR, Garcia HH, Lopez-Urbina T, Tsang VC, Pan W, Gilman RH, Gonzalez AE; Cysticercosis Working Group in Peru, 2013. Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis 7: e2192.
-
5.
Mohan VR, Tharmalingam J, Muliyil J, Oommen A, Dorny P, Vercruysse J, Vedantam R, 2013. Prevalence of porcine cysticercosis in Vellore, South India. Trans R Soc Trop Med Hyg 107: 62–64.
-
6.
Sikasunge CS, Phiri IK, Phiri AM, Siziya S, Dorny P & Willingham AL 3 rd, 2008. Prevalence of Taenia solium porcine cysticercosis in the eastern, southern and western provinces of Zambia. Vet J 176: 240–244.
-
7.
Tsang VC, Brand JA, Boyer AE, 1989. An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis (Taenia solium). J Infect Dis 159: 50–59.
-
8.
Tsang VC, Pilcher JA, Zhou W, Boyer AE, Kamango-Sollo EI, Rhoads ML, Murrell KD, Schantz PM, Gilman RH, 1991. Efficacy of the immunoblot assay for cysticercosis in pigs and modulated expression of distinct IgM/IgG activities to Taenia solium antigens in experimental infections. Vet Immunol Immunopathol 29: 69–78.
-
9.
Garcia HH et al. 2016. Elimination of Taenia solium transmission in northern Peru. N Engl J Med 374: 2335–2344.
-
10.
Brandt JR, Geerts S, De Deken R, Kumar V, Ceulemans F, Brijs L, Falla N, 1992. A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis. Int J Parasitol 22: 471–477.
-
11.
Nguekam A, Zoli AP, Vondou L, Pouedet SM, Assana E, Dorny P, Brandt J, Losson B, Geerts S, 2003. Kinetics of circulating antigens in pigs experimentally infected with Taenia solium eggs. Vet Parasitol 111: 323–332.
-
12.
Guezala MC, Rodriguez S, Zamora H, Garcia HH, Gonzalez AE, Tembo A, Allan JC, Craig PS, 2013. Development of a species-specific coproantigen ELISA for human Taenia solium taeniasis. Am J Trop Med Hyg 81: 433–437.
-
13.
Gemmell MA, 1973. Surveillance of Echinococcus granulosus in dogs with arecoline hydrobromide. Bull World Health Organ 48: 649–652.
-
14.
Liu GH, Lin RQ, Li MW, Liu W, Liu Y, Yuan ZG, Song HQ, Zhao GH, Zhang KX, Zhu XQ, 2011. The complete mitochondrial genomes of three cestode species of Taenia infecting animals and humans. Mol Biol Rep 38: 2249–2256.
-
15.
Bowles J, McManus DP, 1994. Genetic characterization of the Asian Taenia, a newly described taeniid cestode of humans. Am J Trop Med Hyg 50: 33–44.
-
16.
Zhan G, Chen J, Yang Y, Liu N, Jiang W, Gu S, Wang X, Wang Z, 2014. Utility of DNA barcoding in distinguishing species of the family Taeniidae. J Parasitol 100: 542–546.
-
17.
Dorny P, Phiri IK, Vercruysse J, Gabriel S, Willingham AL 3rd, Brandt J, Victor B, Speybroeck N, Berkvens D, 2004. A Bayesian approach for estimating values for prevalence and diagnostic test characteristics of porcine cysticercosis. Int J Parasitol 34: 569–576.
-
18.
Cheng RWK, Ko R, 1991. Cross-reactions between crude antigens of larval Taenia solium (Cysticercus cellulosae) and other helminths of pigs. Vet Parasitol 39: 161–170.
-
19.
Nguyen MT, Gabriël S, Abatih EN, Dorny P, 2016. A systematic review on the global occurrence of Taenia hydatigena in pigs and cattle. Vet Parasitol 226: 97–103.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 124 | 124 | 34 |
| Full Text Views | 842 | 365 | 0 |
| PDF Downloads | 263 | 37 | 0 |