ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Brunetti E, Garcia HH, Junghanss T; on behalf of the members of the International CE Workshop in Lima, P. 2009, 2011. Cystic echinococcosis: chronic, complex, and still neglected. PLoS Negl Trop Dis 5: e1146.
-
2.
Eckert J, Gemmell MA, Meslin FX, Pawlowski ZS, 2001. WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. Paris, France: World Organisation for Animal Health.
-
3.
Pedrosa I, SaÃz A, Arrazola J, Ferreirós J, Pedrosa CS, 2000. Hydatid disease: radiologic and pathologic features and complications. Radiographics 20: 795–817.
-
4.
Brunetti E, White AC, 2012. Cestode infestations: hydatid disease and cysticercosis. Infect Dis Clin North Am 26: 421–435.
-
5.
Brunetti E, Kern P, Vuitton DA, 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 1–16.
-
6.
Mueller PR, Dawson SL, Ferrucci JT, Nardi GL, 1985. Hepatic echinococcal cyst: successful percutaneous drainage. Radiology 155: 627–628.
-
7.
Akhan O, Dincer A, Gököz A, Sayek I, Havlioġlu S, Abbassoġlu O, Eryilmaz M, Besim A, Baris I, 1993. Percutaneous treatment of abdominal hydatid cysts with hypertonic saline and alcohol: an experimental study in sheep. Invest Radiol 28: 121–127.
-
8.
Akhan O, Özmen MN, 1999. Percutaneous treatment of liver hydatid cysts. Eur J Radiol 32: 76–85.
-
9.
Ben Amor N, Gargouri M, Gharbi HA, Ghorbel A, Golvan YJ, Hammou-Jeddi H, Kilani M, Lahmar S, 1986. Treatment of hepatic hydatid cyst in sheep by echographic puncture. Tunis Med 64: 325–331.
-
10.
Ben Amor N, Gargouri M, Gharbi HA, Golvan YJ, Ayachi K, Kchouck H, 1986. Trial therapy of inoperable abdominal hydatid cysts by puncture. Ann Parasitol Hum Comp 61: 689–692.
-
11.
Filice C, Pirola F, Brunetti E, Dughetti S, Strosselli M, Foglieni CS, 1990. A new therapeutic approach for hydatid liver cysts. Aspiration and alcohol injection under sonographic guidance. Gastroenterology 98: 1366–1368.
-
12.
Gargouri M, Ben Amor N, Ben Chehida F, Hammou A, Gharbi HA, Ben Cheikh M, Kchouk H, Ayachi K, Golvan JY, 1990. Percutaneous treatment of hydatid cysts (Echinococcus granulosus). Cardiovasc Intervent Radiol 13: 169–173.
-
13.
WHO Informal Working Group on Echinococcosis, 2001. PAIR: Puncture, Aspiration, Injection, Re-Aspiration an option for the Treatment of Cystic Echinococcosis. Geneva, Switzerland: World Health Organization.
-
14.
Nasseri Moghaddam S, Abrishami A, Malekzadeh R, 2011. Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts. Cochrane Database Syst Rev 1:CD003623.
-
15.
Khuroo MS, Dar MY, Yattoo GN, Zargar SA, Javaid G, Khan BA, Boda MI, 1993. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology 104: 1452–1459.
-
16.
Khuroo MS, Wani NA, Javid G, Khan BA, Yattoo GN, Shah AH, Jeelani SG, 1997. Percutaneous drainage compared with surgery for hepatic hydatid cysts. N Engl J Med 337: 881–887.
-
17.
Smego RA, Bhatti S, Khaliq AA, Beg MA, 2003. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Nephrol Dial Transplant 37: 1073–1083.
-
18.
Smego RA, Sebanego P, 2005. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 9: 69–76.
-
19.
Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, Aknediz A, Cetiner S, Tufan T, 2005. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 years experience with 355 patients. World J Surg 29: 1670–1679.
-
20.
Golemanov B, Grigorov N, Mitova R, Genov J, Vuchev D, Tamarozzi F, Brunetti E, 2011. Efficacy and safety of PAIR for cystic echinococcosis: experience on a large series of patients from Bulgaria. Am J Trop Med Hyg 84: 48–51.
-
21.
Kabaalioğlu A, Çeken K, Alimoglu E, Apaydin A, 2006. Percutaneous imaging-guided treatment of hydatid liver cysts: do long-term results make it a first choice? Eur J Radiol 59: 65–73.
-
22.
Men S, Yücesoy C, Edgüer TR, Hekimoğlu B, 2006. Percutaneous treatment of giant abdominal hydatid cysts: long-term results. Surg Endosc 20: 1600–1606.
-
23.
Akhan O, Islim F, Balci S, Erbahceci A, Akpınar B, Ciftci T, Akinci D, 2016. Percutaneous treatment of simple hepatic cysts: the long-term results of PAIR and catheterization techniques as single-session procedures. Cardiovasc Intervent Radiol 39: 902–908.
-
24.
Neumayr A, Troia G, de Bernardis C, Tamarozzi F, Goblirsch S, Piccoli L, Hatz C, Filice C, Brunetti E, 2011. Justified concern or exaggerated fear: the risk of anaphylaxis in percutaneous treatment of cystic echinococcosis—a systematic literature review. PLoS Negl Trop Dis 5: e1154.
-
25.
Akhan O, Yildiz AE, Akinci D, Yildiz BD, Ciftci T, 2014. Is the adjuvant albendazole treatment really needed with PAIR in the management of liver hydatid cysts? A prospective, randomized trial with short-term follow-up results. Cardiovasc Intervent Radiol 37: 1568–1574.
-
26.
Besim H, Karayalçin K, Hamamci O, Güngör Ç, Korkmaz A, 1998. Scolicidal agents in hydatid cyst surgery. HPB Surg 10: 347–351.
-
27.
Caglar R, Yuzbasioglu MF, Bulbuloglu E, Gul M, Ezberci F, Kale IT, 2008. In vitro effectiveness of different chemical agents on scolices of hydatid cyst. J Invest Surg 21: 71–75.
-
28.
Ciftci IH, Esme H, Sahin DA, Solak O, Sezer M, Dilek ON, 2007. Effect of octenidine dihydrochloride on viability of protoscoleces in hepatic and pulmonary hydatid diseases. J Natl Med Assoc 99: 674–677.
-
29.
Castellano G, Moreno-Sanchez D, Gutierrez J, Moreno-Gonzalez E, Colina F, Solis-Herruzo JA, 1994. Caustic sclerosing cholangitis. Report of four cases and a cumulative review of the literature. Hepatogastroenterology 41: 458–470.
-
30.
Taranto D, Beneduce F, Vitale LM, Loguercio C, Del Vecchio Blanco C, 1995. Chemical sclerosing cholangitis after injection of scolicidal solution. Ital J Gastroenterol 27: 78–79.
-
31.
Houry S, Languille O, Huguier M, Benhamou JP, Belghiti J, Msika S, 1990. Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. Arch Surg 125: 1059–1061.
-
32.
Sahin M, Eryilmaz R, Bulbuloglu E, 2004. The effect of scolicidal agents on liver and biliary tree (experimental study). J Invest Surg 17: 323–326.
-
33.
Filice C, Brunetti E, 1997. Use of PAIR in human cystic echinococcosis. Acta Trop 64: 95–107.
-
34.
Fìlice C, Brunetti E, Bruno R, Crippa FG; WHO-Informal Working Group on Echinococcosis-Pair Network, 2000. Percutaneous drainage of echinococcal cysts (PAIR—puncture, aspiration, injection, reaspiration): results of a worldwide survey for assessment of its safety and efficacy. Gut 47: 156–157.
-
35.
Giorgio A, de Stefano G, Esposito V, Liorre G, Di Sarno A, Giorgio V, Sangiovanni V, Iannece MD, Mariniello N, 2008. Long-term results of percutaneous treatment of hydatid liver cysts: a single center 17 years experience. Infection 36: 256–261.
-
36.
Akhan O, Ozmen MN, Dinçer A, Sayek I, Göçmen A, 1996. Liver hydatid disease: long-term results of percutaneous treatment. Radiology 198: 259–264.
-
37.
Peláez V, Kugler C, Correa D, Del Carpio M, Guangiroli M, Molina J, Marcos E, Lopez E, 2000. PAIR as percutaneous treatment of hydatid liver cysts. Acta Trop 75: 197–202.
-
38.
Stojkovic M, Zwahlen M, Teggi A, Vutova K, Cretu CM, Virdone R, Nicolaidu P, Cobanoglu N, Junghanss T, 2009. Treatment response of cystic echinococcosis to benzimidazoles: a systematic review. PLoS Negl Trop Dis 3: e524.
-
39.
Lötsch F, Naderer J, Skuhala T, Groger M, Auer H, Kaczirek K, Waneck F, Ramharter M, 2016. Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. Parasitol Res 115: 2995–3001.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 463 | 434 | 9 |
| Full Text Views | 422 | 19 | 0 |
| PDF Downloads | 119 | 11 | 0 |
Preliminary Evaluation of Percutaneous Treatment of Echinococcal Cysts without Injection of Scolicidal Agent
Giovanni Firpo
Giovanni Firpo
WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;
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Ambra Vola
Ambra Vola
WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;
Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
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Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
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Raffaella Lissandrin
Raffaella Lissandrin
WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;
Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
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Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
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Francesca Tamarozzi
Francesca Tamarozzi
WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
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Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
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Enrico Brunetti
Enrico Brunetti
WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;
Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
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Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
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Puncture, Aspiration, Injection of scolicidal agent, Re-aspiration is the most widely used percutaneous treatment of cystic echinococcosis (CE). Among its perceived risks is chemical sclerosing cholangitis, a serious complication due to the caustic effect of the scolicidal solution on the biliary tree, when a patent cystobiliary fistula occurs. To simplify the protocol, we decided to omit injection and reaspiration of the scolicidal agent and to implement a full course of albendazole (ABZ) therapy instead of the routine 1-month ABZ prophylaxis. We searched our databases for patients with CL (Cystic Lesion, suspected for CE), CE1, and CE3a cysts treated between October 2007 and January 2017 with percutaneous aspiration followed by at least 1 month of oral ABZ and with an ultrasound follow-up of at least 6 months. Fifteen patients matched our inclusion criteria. Follow-up ranged from 7 to 75 months. The oral ABZ course after the aspiration procedure ranged from 1 to 18 months. Eleven subjects (73.3%) had undergone a course of ABZ before the percutaneous procedure (min 15 days, max 16 months). Ten cysts (62.5%) had reached solidification (stage CE4) in 3 to 69 months. Four other cysts (26.7%) remained stable in stage CE3a, whereas two cysts (13.3%) reactivated to stage CE3b. Procedural perioperative complications occurred in 13.3% of patients, whereas complications during the follow-up occurred in 20% of patients. These proof-of-concept preliminary results are overall comparable with those reported in the literature for other percutaneous treatments, both in terms of response rate, relapse rate, and morbidity.
Author Notes
Financial support: This study was funded through the European Union Seventh Framework Programme (FP7/2007–2013) under the project HERACLES, grant agreement no. [602051].
Authors’ addresses: Giovanni Firpo, WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy, E-mail: giovanni.firpo01@universitadipavia.it. Ambra Vola and Raffaella Lissandrin, WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy, and Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy, E-mails: ambra.vola@gmail.com and raffaella.lissandrin@unipv.it. Francesca Tamarozzi, Center for Tropical Diseases, Sacro Cuore Hospital, Negrar, verona, Italy, and WHO Collaborating Center for Clinical Management of Cystic Echinococcosis, Pavia, Italy, E-mail: f_tamarozzi@yahoo.com. Enrico Brunetti, WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy, Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy, and Department of Clinical, Surgical, Diagnostic and Paediatric Science, University of Pavia, Pavia, Italy, E-mail: enrico.brunetti@unipv.it.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Brunetti E, Garcia HH, Junghanss T; on behalf of the members of the International CE Workshop in Lima, P. 2009, 2011. Cystic echinococcosis: chronic, complex, and still neglected. PLoS Negl Trop Dis 5: e1146.
-
2.
Eckert J, Gemmell MA, Meslin FX, Pawlowski ZS, 2001. WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. Paris, France: World Organisation for Animal Health.
-
3.
Pedrosa I, SaÃz A, Arrazola J, Ferreirós J, Pedrosa CS, 2000. Hydatid disease: radiologic and pathologic features and complications. Radiographics 20: 795–817.
-
4.
Brunetti E, White AC, 2012. Cestode infestations: hydatid disease and cysticercosis. Infect Dis Clin North Am 26: 421–435.
-
5.
Brunetti E, Kern P, Vuitton DA, 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 1–16.
-
6.
Mueller PR, Dawson SL, Ferrucci JT, Nardi GL, 1985. Hepatic echinococcal cyst: successful percutaneous drainage. Radiology 155: 627–628.
-
7.
Akhan O, Dincer A, Gököz A, Sayek I, Havlioġlu S, Abbassoġlu O, Eryilmaz M, Besim A, Baris I, 1993. Percutaneous treatment of abdominal hydatid cysts with hypertonic saline and alcohol: an experimental study in sheep. Invest Radiol 28: 121–127.
-
8.
Akhan O, Özmen MN, 1999. Percutaneous treatment of liver hydatid cysts. Eur J Radiol 32: 76–85.
-
9.
Ben Amor N, Gargouri M, Gharbi HA, Ghorbel A, Golvan YJ, Hammou-Jeddi H, Kilani M, Lahmar S, 1986. Treatment of hepatic hydatid cyst in sheep by echographic puncture. Tunis Med 64: 325–331.
-
10.
Ben Amor N, Gargouri M, Gharbi HA, Golvan YJ, Ayachi K, Kchouck H, 1986. Trial therapy of inoperable abdominal hydatid cysts by puncture. Ann Parasitol Hum Comp 61: 689–692.
-
11.
Filice C, Pirola F, Brunetti E, Dughetti S, Strosselli M, Foglieni CS, 1990. A new therapeutic approach for hydatid liver cysts. Aspiration and alcohol injection under sonographic guidance. Gastroenterology 98: 1366–1368.
-
12.
Gargouri M, Ben Amor N, Ben Chehida F, Hammou A, Gharbi HA, Ben Cheikh M, Kchouk H, Ayachi K, Golvan JY, 1990. Percutaneous treatment of hydatid cysts (Echinococcus granulosus). Cardiovasc Intervent Radiol 13: 169–173.
-
13.
WHO Informal Working Group on Echinococcosis, 2001. PAIR: Puncture, Aspiration, Injection, Re-Aspiration an option for the Treatment of Cystic Echinococcosis. Geneva, Switzerland: World Health Organization.
-
14.
Nasseri Moghaddam S, Abrishami A, Malekzadeh R, 2011. Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts. Cochrane Database Syst Rev 1:CD003623.
-
15.
Khuroo MS, Dar MY, Yattoo GN, Zargar SA, Javaid G, Khan BA, Boda MI, 1993. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology 104: 1452–1459.
-
16.
Khuroo MS, Wani NA, Javid G, Khan BA, Yattoo GN, Shah AH, Jeelani SG, 1997. Percutaneous drainage compared with surgery for hepatic hydatid cysts. N Engl J Med 337: 881–887.
-
17.
Smego RA, Bhatti S, Khaliq AA, Beg MA, 2003. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Nephrol Dial Transplant 37: 1073–1083.
-
18.
Smego RA, Sebanego P, 2005. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 9: 69–76.
-
19.
Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, Aknediz A, Cetiner S, Tufan T, 2005. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 years experience with 355 patients. World J Surg 29: 1670–1679.
-
20.
Golemanov B, Grigorov N, Mitova R, Genov J, Vuchev D, Tamarozzi F, Brunetti E, 2011. Efficacy and safety of PAIR for cystic echinococcosis: experience on a large series of patients from Bulgaria. Am J Trop Med Hyg 84: 48–51.
-
21.
Kabaalioğlu A, Çeken K, Alimoglu E, Apaydin A, 2006. Percutaneous imaging-guided treatment of hydatid liver cysts: do long-term results make it a first choice? Eur J Radiol 59: 65–73.
-
22.
Men S, Yücesoy C, Edgüer TR, Hekimoğlu B, 2006. Percutaneous treatment of giant abdominal hydatid cysts: long-term results. Surg Endosc 20: 1600–1606.
-
23.
Akhan O, Islim F, Balci S, Erbahceci A, Akpınar B, Ciftci T, Akinci D, 2016. Percutaneous treatment of simple hepatic cysts: the long-term results of PAIR and catheterization techniques as single-session procedures. Cardiovasc Intervent Radiol 39: 902–908.
-
24.
Neumayr A, Troia G, de Bernardis C, Tamarozzi F, Goblirsch S, Piccoli L, Hatz C, Filice C, Brunetti E, 2011. Justified concern or exaggerated fear: the risk of anaphylaxis in percutaneous treatment of cystic echinococcosis—a systematic literature review. PLoS Negl Trop Dis 5: e1154.
-
25.
Akhan O, Yildiz AE, Akinci D, Yildiz BD, Ciftci T, 2014. Is the adjuvant albendazole treatment really needed with PAIR in the management of liver hydatid cysts? A prospective, randomized trial with short-term follow-up results. Cardiovasc Intervent Radiol 37: 1568–1574.
-
26.
Besim H, Karayalçin K, Hamamci O, Güngör Ç, Korkmaz A, 1998. Scolicidal agents in hydatid cyst surgery. HPB Surg 10: 347–351.
-
27.
Caglar R, Yuzbasioglu MF, Bulbuloglu E, Gul M, Ezberci F, Kale IT, 2008. In vitro effectiveness of different chemical agents on scolices of hydatid cyst. J Invest Surg 21: 71–75.
-
28.
Ciftci IH, Esme H, Sahin DA, Solak O, Sezer M, Dilek ON, 2007. Effect of octenidine dihydrochloride on viability of protoscoleces in hepatic and pulmonary hydatid diseases. J Natl Med Assoc 99: 674–677.
-
29.
Castellano G, Moreno-Sanchez D, Gutierrez J, Moreno-Gonzalez E, Colina F, Solis-Herruzo JA, 1994. Caustic sclerosing cholangitis. Report of four cases and a cumulative review of the literature. Hepatogastroenterology 41: 458–470.
-
30.
Taranto D, Beneduce F, Vitale LM, Loguercio C, Del Vecchio Blanco C, 1995. Chemical sclerosing cholangitis after injection of scolicidal solution. Ital J Gastroenterol 27: 78–79.
-
31.
Houry S, Languille O, Huguier M, Benhamou JP, Belghiti J, Msika S, 1990. Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. Arch Surg 125: 1059–1061.
-
32.
Sahin M, Eryilmaz R, Bulbuloglu E, 2004. The effect of scolicidal agents on liver and biliary tree (experimental study). J Invest Surg 17: 323–326.
-
33.
Filice C, Brunetti E, 1997. Use of PAIR in human cystic echinococcosis. Acta Trop 64: 95–107.
-
34.
Fìlice C, Brunetti E, Bruno R, Crippa FG; WHO-Informal Working Group on Echinococcosis-Pair Network, 2000. Percutaneous drainage of echinococcal cysts (PAIR—puncture, aspiration, injection, reaspiration): results of a worldwide survey for assessment of its safety and efficacy. Gut 47: 156–157.
-
35.
Giorgio A, de Stefano G, Esposito V, Liorre G, Di Sarno A, Giorgio V, Sangiovanni V, Iannece MD, Mariniello N, 2008. Long-term results of percutaneous treatment of hydatid liver cysts: a single center 17 years experience. Infection 36: 256–261.
-
36.
Akhan O, Ozmen MN, Dinçer A, Sayek I, Göçmen A, 1996. Liver hydatid disease: long-term results of percutaneous treatment. Radiology 198: 259–264.
-
37.
Peláez V, Kugler C, Correa D, Del Carpio M, Guangiroli M, Molina J, Marcos E, Lopez E, 2000. PAIR as percutaneous treatment of hydatid liver cysts. Acta Trop 75: 197–202.
-
38.
Stojkovic M, Zwahlen M, Teggi A, Vutova K, Cretu CM, Virdone R, Nicolaidu P, Cobanoglu N, Junghanss T, 2009. Treatment response of cystic echinococcosis to benzimidazoles: a systematic review. PLoS Negl Trop Dis 3: e524.
-
39.
Lötsch F, Naderer J, Skuhala T, Groger M, Auer H, Kaczirek K, Waneck F, Ramharter M, 2016. Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. Parasitol Res 115: 2995–3001.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 463 | 434 | 9 |
| Full Text Views | 422 | 19 | 0 |
| PDF Downloads | 119 | 11 | 0 |