Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD, 2007. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7: 93–104.
-
2.
WHO Global Malaria Programme, 2012. Intermittent Preventive Treatment of Malaria in Pregnancy Using Sulfadoxine-Pyrimethamine (IPTp-SP). Available at: http://www.who.int/malaria/publications/atoz/who_iptp_sp_policy_recommendation/en/. Accessed May 1, 2013.
-
3.
Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW, 2012. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Lancet Infect Dis 12: 942–949.
-
4.
Van Eijk AM, Hill J, Larsen DA, Webster J, Steketee RW, Eisele TP, ter Kuile FO, 2013. Coverage of intermittent preventive treatment and insecticide-treated nets for the control of malaria during pregnancy in sub-Saharan Africa: asynthesis and meta-analysis of national survey data, 2009–11. Lancet Infect Dis 13: 1029–1042.
-
5.
Thiam S, Kimotho V, Gatonga P, 2013. Why are IPTp coverage targets so elusive in sub-Saharan Africa? A systematic review of health system barriers. Malar J 12: 353.
-
6.
Grietens KP, Gies S, Coulibaly SO, Ky C, Somda J, Toomer E, Muela Ribera J, D’Alessandro U, 2010. Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina Faso. PLoS One 5: e12013.
-
7.
Hill J et al., 2015. Access and use of interventions to prevent and treat malaria among pregnant women in Kenya and Mali: a qualitative study. PLoS One 10: 1–23.
-
8.
Naidoo I, Roper C, 2011. Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. Parasitology 138: 1469–1479.
-
9.
Geiger C, Compaore G, Coulibaly B, Sie A, Dittmer M, Sanchez C, Lanzer M, Jänisch T, 2014. Substantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine-pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina Faso. Trop Med Int Health 19: 690–697.
-
10.
Mockenhaupt FP, Bedu-Addo G, Eggelte TA, Hommerich L, Holmberg V, von Oertzen C, Bienzle U, 2008. Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana. J Infect Dis 198: 1545–1549.
-
11.
Naidoo I, Roper C, 2013. Mapping “partially resistant”, “fully resistant”, and “super resistant” malaria. Trends Parasitol 29: 505–515.
-
12.
Braun V, Rempis E, Schnack A, Decker S, Rubaihayo J, Tumwesigye NM, Theuring S, Harms G, Busingye P, Mockenhaupt FP, 2015. Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda. Malar J 14: 372.
-
13.
Harrington WE, Mutabingwa TK, Kabyemela E, Fried M, Duffy PE, 2011. Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance. Clin Infect Dis 53: 224–230.
-
14.
Desai M et al., 2016. Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight. Clin Infect Dis 62: 323–333.
-
15.
Chico RM, Cano J, Ariti C, Collier TJ, Chandramohan D, Roper C, Greenwood B, 2015. Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis. Trop Med Int Health 20: 1621–1633.
-
16.
World Health Organization, 2005. The Roll Back Malaria Strategy for Improving Access to Treatment through Home Management of Malaria. Geneva, Switzerland: World Health Organization.
-
17.
Ruizendaal E, Dierickx S, Peeters Grietens K, Schallig HDFH, Pagnoni F, Mens PF, 2014. Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review. Malar J 13: 229.
-
18.
Scott S et al., 2014. Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health in The Gambia, Burkina Faso and Benin: study protocol for a randomized controlled trial. Trials 15: 340.
-
19.
World Health Organization, 2016. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. Geneva, Switzerland: World Health Organization.
-
20.
Kattenberg JH, Tahita CM, Versteeg IA, Tinto H, Traoré-Coulibaly M, Schallig HD, Mens PF, 2012. Antigen persistence of rapid diagnostic tests in pregnant women in Nanoro, Burkina Faso, and the implications for the diagnosis of malaria in pregnancy. Trop Med Int Health 17: 550–557.
-
21.
Hermsen CC, Telgt DS, Linders EH, van de Locht LA, Eling WM, Mensink EJ, Sauerwein RW, 2001. Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR. Mol Biochem Parasitol 118: 247–251.
-
22.
Cottrell G, Moussiliou A, Luty AJF, Cot M, Fievet N, Massougbodji A, Deloron P, Tuikue Ndam N, 2015. Submicroscopic Plasmodium falciparum infections are associated with maternal anemia, premature births, and low birth weight. Clin Infect Dis 60: 1481–1488.
-
23.
Kattenberg JH, Ochodo EA, Boer KR, Schallig HD, Mens PF, Leeflang MM, 2011. Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women. Malar J 10: 321.
-
24.
World Health Organization, 2012. Malaria Rapid Diagnostic Test Performance: Results of WHO Product Testing of Malaria RDTs: Round 4, Vol 4. Geneva, Switzerland: WHO.
-
25.
Joanny F, Löhr SJ, Engleitner T, Lell B, Mordmüller B, 2014. Limit of blank and limit of detection of Plasmodium falciparum thick blood smear microscopy in a routine setting in Central Africa. Malar J 13: 234.
-
26.
Kyabayinze DJ et al., 2016. HRP2 and pLDH-based rapid diagnostic tests, expert microscopy, and PCR for detection of malaria infection during pregnancy and at delivery in areas of varied transmission: a prospective cohort study in Burkina Faso and Uganda. PLoS One 11: e0156954.
-
27.
Williams JE et al., 2016. The performance of a rapid diagnostic test in detecting malaria infection in pregnant women and the impact of missed infections. Clin Infect Dis 62: 837–844.
-
28.
Fernandes S et al., 2016. Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa: analysis and modelling of results from a non-inferiority trial. Malar J 15: 493.
-
29.
Jarra W, Snounou G, 1998. Only viable parasites are detected by PCR following clearance of rodent malarial infections by drug treatment or immune responses. Infect Immun 66: 3783–3787.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 74 | 74 | 28 |
| Full Text Views | 519 | 143 | 0 |
| PDF Downloads | 196 | 42 | 0 |
Evaluation of Malaria Screening during Pregnancy with Rapid Diagnostic Tests Performed by Community Health Workers in Burkina Faso
Esmée Ruizendaal
Esmée Ruizendaal
Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands;
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Henk D. F. H. Schallig
Henk D. F. H. Schallig
Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands;
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Susana Scott
Susana Scott
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom;
Disease Control and Elimination, Medical Research Council Unit, Fajara, The Gambia;
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Disease Control and Elimination, Medical Research Council Unit, Fajara, The Gambia;
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Maminata Traore-Coulibaly
Maminata Traore-Coulibaly
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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John Bradley
John Bradley
Medical Research Council (MRC) Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, United Kingdom;
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Palpouguini Lompo
Palpouguini Lompo
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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Hamtandi M. Natama
Hamtandi M. Natama
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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Ousmane Traore
Ousmane Traore
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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Innocent Valea
Innocent Valea
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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Susan Dierickx
Susan Dierickx
Medical Anthropology Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium;
Amsterdam Institute of Social Science Research, Amsterdam, The Netherlands;
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Amsterdam Institute of Social Science Research, Amsterdam, The Netherlands;
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Koiné M. Drabo
Koiné M. Drabo
Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso;
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Franco Pagnoni
Franco Pagnoni
Chemin Petite Boissière 44, Geneva, Switzerland;
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Umberto d’ Alessandro
Umberto d’ Alessandro
Disease Control and Elimination, Medical Research Council Unit, Fajara, The Gambia;
Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Halidou Tinto
Halidou Tinto
Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso;
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Petra F. Mens
Petra F. Mens
Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands;
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One of the current strategies to prevent malaria in pregnancy is intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP). However, in order for pregnant women to receive an adequate number of SP doses, they should attend a health facility on a regular basis. In addition, SP resistance may decrease IPTp-SP efficacy. New or additional interventions for preventing malaria during pregnancy are therefore warranted. Because it is known that community health workers (CHWs) can diagnose and treat malaria in children, in this study screening and treatment of malaria in pregnancy by CHWs was evaluated as an addition to the regular IPTp-SP program. CHWs used rapid diagnostic tests (RDTs) for screening and artemether–lumefantrine was given in case of a positive RDT. Overall, CHWs were able to conduct RDTs with a sensitivity of 81.5% (95% confidence interval [CI] 67.9–90.2) and high specificity of 92.1% (95% CI 89.9–93.9) compared with microscopy. After a positive RDT, 79.1% of women received artemether–lumefantrine. When treatment was not given, this was largely due to the woman being already under treatment. Almost all treated women finished the full course of artemether–lumefantrine (96.4%). In conclusion, CHWs are capable of performing RDTs with high specificity and acceptable sensitivity, the latter being dependent on the limit of detection of RDTs. Furthermore, CHWs showed excellent adherence to test results and treatment guidelines, suggesting they can be deployed for screen and treat approaches of malaria in pregnancy.
Author Notes
Authors addresses: Esmée Ruizendaal, Henk D. F. H. Schallig, and Petra F. Mens, Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands, E-mails: esmee.ruizendaal@gmail.com, h.d.schallig@amc.uva.nl, and p.f.mens@amc.uva.nl. Susana Scott, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, and Disease Control and Elimination, Medical Research Council Unit, Fajara, The Gambia, E-mail: sscott@mrc.gm. Maminata Traore-Coulibaly, Palpouguini Lompo, Hamtandi M. Natama, Ousmane Traore, Innocent Valea, and Halidou Tinto, Institut de Recherche en Sciences de la Santé-Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso, E-mails: traore_maminata@yahoo.fr, palponet@yahoo.fr, natamagloire@yahoo.fr, ousmane_tra@yahoo.fr, innocentvalea@yahoo.fr, and halidoutinto@gmail.com. John Bradley, Medical Research Council (MRC) Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, United Kingdom, E-mail: john.bradley@lshtm.ac.uk. Susan Dierickx, Medical Anthropology Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium, and Amsterdam Institute of Social Science Research, Amsterdam, The Netherlands, E-mail: susan.dierickx@vub.ac.be. Koiné M. Drabo, Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso, E-mail: m_drabok@yahoo.fr. Franco Pagnoni, Chemin Petite Boissière, Geneva, Switzerland, E-mail: fpagnoni47@gmail.com. Umberto d’Alessandro, Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, and Disease Control and Elimination, Medical Research Council Unit, Fajara, The Gambia, E-mail: udalessandro@mrc.gm.
Financial support: This study was funded by European Community’s Seventh Framework Programme under grant agreement no. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial “COSMIC”).
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD, 2007. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7: 93–104.
-
2.
WHO Global Malaria Programme, 2012. Intermittent Preventive Treatment of Malaria in Pregnancy Using Sulfadoxine-Pyrimethamine (IPTp-SP). Available at: http://www.who.int/malaria/publications/atoz/who_iptp_sp_policy_recommendation/en/. Accessed May 1, 2013.
-
3.
Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW, 2012. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Lancet Infect Dis 12: 942–949.
-
4.
Van Eijk AM, Hill J, Larsen DA, Webster J, Steketee RW, Eisele TP, ter Kuile FO, 2013. Coverage of intermittent preventive treatment and insecticide-treated nets for the control of malaria during pregnancy in sub-Saharan Africa: asynthesis and meta-analysis of national survey data, 2009–11. Lancet Infect Dis 13: 1029–1042.
-
5.
Thiam S, Kimotho V, Gatonga P, 2013. Why are IPTp coverage targets so elusive in sub-Saharan Africa? A systematic review of health system barriers. Malar J 12: 353.
-
6.
Grietens KP, Gies S, Coulibaly SO, Ky C, Somda J, Toomer E, Muela Ribera J, D’Alessandro U, 2010. Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina Faso. PLoS One 5: e12013.
-
7.
Hill J et al., 2015. Access and use of interventions to prevent and treat malaria among pregnant women in Kenya and Mali: a qualitative study. PLoS One 10: 1–23.
-
8.
Naidoo I, Roper C, 2011. Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. Parasitology 138: 1469–1479.
-
9.
Geiger C, Compaore G, Coulibaly B, Sie A, Dittmer M, Sanchez C, Lanzer M, Jänisch T, 2014. Substantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine-pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina Faso. Trop Med Int Health 19: 690–697.
-
10.
Mockenhaupt FP, Bedu-Addo G, Eggelte TA, Hommerich L, Holmberg V, von Oertzen C, Bienzle U, 2008. Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana. J Infect Dis 198: 1545–1549.
-
11.
Naidoo I, Roper C, 2013. Mapping “partially resistant”, “fully resistant”, and “super resistant” malaria. Trends Parasitol 29: 505–515.
-
12.
Braun V, Rempis E, Schnack A, Decker S, Rubaihayo J, Tumwesigye NM, Theuring S, Harms G, Busingye P, Mockenhaupt FP, 2015. Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda. Malar J 14: 372.
-
13.
Harrington WE, Mutabingwa TK, Kabyemela E, Fried M, Duffy PE, 2011. Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance. Clin Infect Dis 53: 224–230.
-
14.
Desai M et al., 2016. Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight. Clin Infect Dis 62: 323–333.
-
15.
Chico RM, Cano J, Ariti C, Collier TJ, Chandramohan D, Roper C, Greenwood B, 2015. Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis. Trop Med Int Health 20: 1621–1633.
-
16.
World Health Organization, 2005. The Roll Back Malaria Strategy for Improving Access to Treatment through Home Management of Malaria. Geneva, Switzerland: World Health Organization.
-
17.
Ruizendaal E, Dierickx S, Peeters Grietens K, Schallig HDFH, Pagnoni F, Mens PF, 2014. Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review. Malar J 13: 229.
-
18.
Scott S et al., 2014. Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health in The Gambia, Burkina Faso and Benin: study protocol for a randomized controlled trial. Trials 15: 340.
-
19.
World Health Organization, 2016. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. Geneva, Switzerland: World Health Organization.
-
20.
Kattenberg JH, Tahita CM, Versteeg IA, Tinto H, Traoré-Coulibaly M, Schallig HD, Mens PF, 2012. Antigen persistence of rapid diagnostic tests in pregnant women in Nanoro, Burkina Faso, and the implications for the diagnosis of malaria in pregnancy. Trop Med Int Health 17: 550–557.
-
21.
Hermsen CC, Telgt DS, Linders EH, van de Locht LA, Eling WM, Mensink EJ, Sauerwein RW, 2001. Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR. Mol Biochem Parasitol 118: 247–251.
-
22.
Cottrell G, Moussiliou A, Luty AJF, Cot M, Fievet N, Massougbodji A, Deloron P, Tuikue Ndam N, 2015. Submicroscopic Plasmodium falciparum infections are associated with maternal anemia, premature births, and low birth weight. Clin Infect Dis 60: 1481–1488.
-
23.
Kattenberg JH, Ochodo EA, Boer KR, Schallig HD, Mens PF, Leeflang MM, 2011. Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women. Malar J 10: 321.
-
24.
World Health Organization, 2012. Malaria Rapid Diagnostic Test Performance: Results of WHO Product Testing of Malaria RDTs: Round 4, Vol 4. Geneva, Switzerland: WHO.
-
25.
Joanny F, Löhr SJ, Engleitner T, Lell B, Mordmüller B, 2014. Limit of blank and limit of detection of Plasmodium falciparum thick blood smear microscopy in a routine setting in Central Africa. Malar J 13: 234.
-
26.
Kyabayinze DJ et al., 2016. HRP2 and pLDH-based rapid diagnostic tests, expert microscopy, and PCR for detection of malaria infection during pregnancy and at delivery in areas of varied transmission: a prospective cohort study in Burkina Faso and Uganda. PLoS One 11: e0156954.
-
27.
Williams JE et al., 2016. The performance of a rapid diagnostic test in detecting malaria infection in pregnant women and the impact of missed infections. Clin Infect Dis 62: 837–844.
-
28.
Fernandes S et al., 2016. Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa: analysis and modelling of results from a non-inferiority trial. Malar J 15: 493.
-
29.
Jarra W, Snounou G, 1998. Only viable parasites are detected by PCR following clearance of rodent malarial infections by drug treatment or immune responses. Infect Immun 66: 3783–3787.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 74 | 74 | 28 |
| Full Text Views | 519 | 143 | 0 |
| PDF Downloads | 196 | 42 | 0 |