Yin JH, Zhou SS, Xia ZG, Wang RB, Qian YJ, Yang WZ, Zhou XN, 2014. Historical patterns of malaria transmission in China. Adv Parasitol 86: 1–19.
Li JH, Li J, Qin YX, Guo CK, Huang YM, Lin Z, 2014. Appraisal of the effect and measures on control malaria for 60 years in Guangxi. J Trop Med 14: 361–364.
Ministry of Health, 2006. National Malaria Control Programme (2006–2015). Beijing, China: Ministry of Health.
Feng J, Xia ZG, Vong S, Yang WZ, Zhou SS, Xiao N, 2014. Preparedness for malaria resurgence in China: case study on imported cases in 2000–2012. Adv Parasitol 86: 231–265.
Wampfler R, Robinson L, Hofmann N, Waltmann A, Betuela I, Silkey M, Siba P, Smith T, Mueller I, Felger I, 2014. Dynamics of P. vivax clones in a cohort of children with or without primaquine treatment at baseline. Malar J 13 (Suppl 1): O24.
Centers for Disease Control and Prevention, 2005. Late relapse of Plasmodium ovale malaria–Philadelphia, Pennsylvania, November 2004. MMWR Morb Mortal Wkly Rep 54: 1231–1233.
Siala E, Gastli M, Essid R, Jemal S, Ben Abdallah R, Ben Abda I, Aoun K, Bouratbine A, 2015. Late relapse of imported Plasmodium ovale malaria: a case report. Tunis Med 93: 347–350.
Coldren RL, Jongsakul K, Vayakornvichit S, Noedl H, Fukudas MM, 2007. Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman. Am J Trop Med Hyg 77: 992–994.
Mellon G, Ficko C, Thellier M, Kendjo E, Aoun O, Adriamanantena D, Rapp C, French National Reference Center for Imported Malaria Study Group, 2014. Two cases of late Plasmodium ovale presentation in military personnel. J Travel Med 21: 52–54.
Baird JK, 2016. Attacking Plasmodium vivax. Am J Trop Med Hyg 95: 1–3.
Imwong M et al.., 2007. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis 195: 927–933.
White NJ, 2011. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J 10: 297.
Kotwal RS, Wenzel RB, Sterling RA, Porter WD, Jordan NN, Petruccelli BP, 2005. An outbreak of malaria in US Army Rangers returning from Afghanistan. JAMA 293: 212–216.
Wells TN, Burrows JN, Baird JK, 2010. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol 26: 145–151.
Hanna JN, Ritchie SA, Eisen DP, Cooper RD, Brookes DL, Montgomery BL, 2004. An outbreak of Plasmodium vivax malaria in far north Queensland, 2002. Med J Aust 180: 24–28.
Feng J, Xiao H, Zhang L, Yan H, Feng X, Fang W, Xia Z, 2015. The Plasmodium vivax in China: decreased in local cases but increased imported cases from southeast Asia and Africa. Sci Rep 5: 8847.
Feng J, Liu J, Feng XY, Zhang L, Xiao HH, Xia ZG, 2016. Towards malaria elimination: monitoring and evaluation of the “1-3-7” approach at the China–Myanmar border. Am J Trop Med Hyg 95: 806–810.
Zhou SS et al.., 2015. China’s 1-3-7 surveillance and response strategy for malaria elimination: is case reporting, investigation and foci response happening according to plan? Infect Dis Poverty 4: 55.
Feng J, Xiao H, Xia Z, Zhang L, Xiao N, 2015. Analysis of malaria epidemiological characteristics in the People’s Republic of China, 2004–2013. Am J Trop Med Hyg 93: 293–299.
Ministry of Health, 2010. National Malaria Elimination Action Plan (2010–2020). Beijing, China: Ministry of Health.
Xiao D, Long Y, Wang S, Wu K, Xu D, Li H, Wang G, Yan Y, 2012. Epidemic distribution and variation of Plasmodium falciparum and Plasmodium vivax malaria in Hainan, China during 1995–2008. Am J Trop Med Hyg 87: 646–654.
Zhou SS, Tang L, Sheng HF, Wang Y, 2005. Malaria situation in the People’s Republic of China in 2004. Chin J Parasitol Parasit Dis 24: 1–3.
Zhou SS, Wang Y, Tang LH, 2006. Malaria situation in the People’s Republic of China in 2005. Chin J Parasitol Parasit Dis 24: 401–403.
Zhou SS, Wang Y, Tang LH, 2007. Malaria situation in the People’s Republic of China in 2006. Chin J Parasitol Parasit Dis 25: 439–441.
Zhou SS, Wang Y, Fang W, Tang LH, 2008. Malaria situation in the People’s Republic of China in 2007. Chin J Parasitol Parasit Dis 26: 401–403.
Zhou SS, Wang Y, Fang W, Tang LH, 2009. Malaria situation in the People’s Republic of China in 2008. Chin J Parasitol Parasit Dis 27: 455–456.
Zhou SS, Wang Y, Xia ZG, 2011. Malaria situation in the People’s Republic of China in 2009. Chin J Parasitol Parasit Dis 29: 1–3.
Zhou SS, Wang Y, Li Y, 2011. Malaria situation in the People’s Republic of China in 2010. Chin J Parasitol Parasit Dis 29: 401–403.
Xia ZG, Yang MN, Zhou SS, 2012. Malaria situation in the People’s Republic of China in 2011. Chin J Parasitol Parasit Dis 30: 419–422.
Xia ZG, Feng J, Zhou SS, 2013. Malaria situation in the People’s Republic of China in 2012. Chin J Parasitol Parasit Dis 31: 413–418.
Zhang L, Feng J, Xia ZG, 2014. Malaria situation in the People’s Republic of China in 2013. Chin J Parasitol Parasit Dis 32: 407–413.
Zhang L, Zhou SS, Feng J, Fang W, Xia ZG, 2015. Malaria situation in the People’s Republic of China in 2014. Chin J Parasitol Parasit Dis 33: 319–326.
Zhang L, Feng J, Zhang SS, Xia ZG, Zhou SS, 2016. Malaria situation in the People’s Republic of China in 2015. Chin J Parasitol Parasit Dis 34: 477–481.
Li Z et al.., 2015. Malaria imported from Ghana by returning gold miners, China, 2013. Emerg Infect Dis 21: 864–867.
Feng J, Li J, Yan H, Feng X, Xia Z, 2015. Evaluation of antimalarial resistance marker polymorphism in returned migrant workers in China. Antimicrob Agents Chemother 59: 326–330.
Ling KM, Li J, Yang YC, Wei SJ, Huang YM, Li JH, Guo CK, Wei HY, 2015. Characteristics of imported malaria epidemic in Guangxi, 2013. Mod Prev Med 24: 2439–2442.
Guo CK, Li JH, Jing YX, 2007. Investigation on geographical distribution, ecological feature and malaria transmission of Anopheles in Guangxi. Chin J Vector Bio & Control 18: 112–115.
Wang WM, Zhou HY, Liu YB, Li JL, Zhu GD, Tang JX, Cao YY, Gu YP, 2012. Establishment of early warning system of malaria epidemic situation in Jiangsu Province I impact of temperature on development of Plasmodium vivax in Anopheles sinensis in Jiangsu Province. Chin J Schistosomasis Control 24: 581–584.
National Health and Family Planning Commission, 2016. Technical Regulations for Application of Antimalarials. Beijing, China: National Health and Family Planning Commission.
White NJ, 2011. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J 10: 297.
Battle KE et al.., 2014. Geographical variation in Plasmodium vivax relapse. Malar J 13: 144.
Mao W, Li J, Wei HY, Lin KM, Huang YM, 2013. Long-term effects of artesunate combined with azithromycin on Plasmodium vivax malaria. Chin Trop Med 13: 614–615, 628.
Past two years | Past Year | Past 30 Days | |
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The incidence of an indigenous malaria, defined as malaria acquired by a local mosquito transmission, declined from 2004 to 2015 in the Guangxi Zhuang Autonomous Region. However, imported malaria, defined as malaria acquired from other endemic regions outside of China, has been increasing in the region, as in the rest of the country, particularly the disease caused by Plasmodium falciparum. A retrospective study was conducted to explore malaria-endemic characteristics in Guangxi during the 2004–2015 timeframe; a total of 2,726 confirmed malaria cases were reported, and the majority (90.3%) were due to P. falciparum (N = 1,697 [62.2%]) and Plasmodium vivax (N = 765 [28.1%]). Thirty-four indigenous cases (1.2%) were observed, with no cases of transmission recorded since 2012. Imported P. vivax and Plasmodium ovale infections increased since 2013. The interval between returning to China and the onset of illness was longer for P. vivax and P. ovale infections than for P. falciparum and Plasmodium malariae infections. The difference interval among the species is likely because of the relapse of P. vivax and P. ovale caused by the activation of the latent hypnozoites. Therefore, health clinics should raise awareness and carry out epidemiological studies and follow-up surveys on migrant workers to avoid misdiagnosis and mistreatment. The evaluation of radical treatment should be carried out using a genotyping technology based on glucose-6-phosphate dehydrogenase deficiency levels, and some new drugs active against the hypnozoites should be developed to mitigate malaria in the region.
Authors’ addresses: Kangming Lin, Haiyan Wei, Jun Li, Weiwei Zhang, Shujiao Wei, Yichao Yang, Yaming Huang, and Xiangyang Feng, Institute of Parasitic Diseases, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Guangxi, People’s Republic of China, E-mails: linkangming814@163.com, whym_006@163.com, lijun-68@21cn.com, 27330579@qq.com, weijiu-197@163.com, yychao@tom.com, 1724501964@qq.com, and 981458660@qq.com. Weikang Jiang, Hong Tu, and Jun Feng, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People’s Republic of China, Key Laboratory of Parasite and Vector Biology, MOH, Shanghai 200025, People’s Republic of China, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, People’s Republic of China, and National Center for International Research on Tropical Diseases, Shanghai 200025, People’s Republic of China, E-mails: cdcshjwk2002@yahoo.com.cn, tuhong372@163.com, and fjphilip1983@hotmail.com.
Yin JH, Zhou SS, Xia ZG, Wang RB, Qian YJ, Yang WZ, Zhou XN, 2014. Historical patterns of malaria transmission in China. Adv Parasitol 86: 1–19.
Li JH, Li J, Qin YX, Guo CK, Huang YM, Lin Z, 2014. Appraisal of the effect and measures on control malaria for 60 years in Guangxi. J Trop Med 14: 361–364.
Ministry of Health, 2006. National Malaria Control Programme (2006–2015). Beijing, China: Ministry of Health.
Feng J, Xia ZG, Vong S, Yang WZ, Zhou SS, Xiao N, 2014. Preparedness for malaria resurgence in China: case study on imported cases in 2000–2012. Adv Parasitol 86: 231–265.
Wampfler R, Robinson L, Hofmann N, Waltmann A, Betuela I, Silkey M, Siba P, Smith T, Mueller I, Felger I, 2014. Dynamics of P. vivax clones in a cohort of children with or without primaquine treatment at baseline. Malar J 13 (Suppl 1): O24.
Centers for Disease Control and Prevention, 2005. Late relapse of Plasmodium ovale malaria–Philadelphia, Pennsylvania, November 2004. MMWR Morb Mortal Wkly Rep 54: 1231–1233.
Siala E, Gastli M, Essid R, Jemal S, Ben Abdallah R, Ben Abda I, Aoun K, Bouratbine A, 2015. Late relapse of imported Plasmodium ovale malaria: a case report. Tunis Med 93: 347–350.
Coldren RL, Jongsakul K, Vayakornvichit S, Noedl H, Fukudas MM, 2007. Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman. Am J Trop Med Hyg 77: 992–994.
Mellon G, Ficko C, Thellier M, Kendjo E, Aoun O, Adriamanantena D, Rapp C, French National Reference Center for Imported Malaria Study Group, 2014. Two cases of late Plasmodium ovale presentation in military personnel. J Travel Med 21: 52–54.
Baird JK, 2016. Attacking Plasmodium vivax. Am J Trop Med Hyg 95: 1–3.
Imwong M et al.., 2007. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis 195: 927–933.
White NJ, 2011. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J 10: 297.
Kotwal RS, Wenzel RB, Sterling RA, Porter WD, Jordan NN, Petruccelli BP, 2005. An outbreak of malaria in US Army Rangers returning from Afghanistan. JAMA 293: 212–216.
Wells TN, Burrows JN, Baird JK, 2010. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol 26: 145–151.
Hanna JN, Ritchie SA, Eisen DP, Cooper RD, Brookes DL, Montgomery BL, 2004. An outbreak of Plasmodium vivax malaria in far north Queensland, 2002. Med J Aust 180: 24–28.
Feng J, Xiao H, Zhang L, Yan H, Feng X, Fang W, Xia Z, 2015. The Plasmodium vivax in China: decreased in local cases but increased imported cases from southeast Asia and Africa. Sci Rep 5: 8847.
Feng J, Liu J, Feng XY, Zhang L, Xiao HH, Xia ZG, 2016. Towards malaria elimination: monitoring and evaluation of the “1-3-7” approach at the China–Myanmar border. Am J Trop Med Hyg 95: 806–810.
Zhou SS et al.., 2015. China’s 1-3-7 surveillance and response strategy for malaria elimination: is case reporting, investigation and foci response happening according to plan? Infect Dis Poverty 4: 55.
Feng J, Xiao H, Xia Z, Zhang L, Xiao N, 2015. Analysis of malaria epidemiological characteristics in the People’s Republic of China, 2004–2013. Am J Trop Med Hyg 93: 293–299.
Ministry of Health, 2010. National Malaria Elimination Action Plan (2010–2020). Beijing, China: Ministry of Health.
Xiao D, Long Y, Wang S, Wu K, Xu D, Li H, Wang G, Yan Y, 2012. Epidemic distribution and variation of Plasmodium falciparum and Plasmodium vivax malaria in Hainan, China during 1995–2008. Am J Trop Med Hyg 87: 646–654.
Zhou SS, Tang L, Sheng HF, Wang Y, 2005. Malaria situation in the People’s Republic of China in 2004. Chin J Parasitol Parasit Dis 24: 1–3.
Zhou SS, Wang Y, Tang LH, 2006. Malaria situation in the People’s Republic of China in 2005. Chin J Parasitol Parasit Dis 24: 401–403.
Zhou SS, Wang Y, Tang LH, 2007. Malaria situation in the People’s Republic of China in 2006. Chin J Parasitol Parasit Dis 25: 439–441.
Zhou SS, Wang Y, Fang W, Tang LH, 2008. Malaria situation in the People’s Republic of China in 2007. Chin J Parasitol Parasit Dis 26: 401–403.
Zhou SS, Wang Y, Fang W, Tang LH, 2009. Malaria situation in the People’s Republic of China in 2008. Chin J Parasitol Parasit Dis 27: 455–456.
Zhou SS, Wang Y, Xia ZG, 2011. Malaria situation in the People’s Republic of China in 2009. Chin J Parasitol Parasit Dis 29: 1–3.
Zhou SS, Wang Y, Li Y, 2011. Malaria situation in the People’s Republic of China in 2010. Chin J Parasitol Parasit Dis 29: 401–403.
Xia ZG, Yang MN, Zhou SS, 2012. Malaria situation in the People’s Republic of China in 2011. Chin J Parasitol Parasit Dis 30: 419–422.
Xia ZG, Feng J, Zhou SS, 2013. Malaria situation in the People’s Republic of China in 2012. Chin J Parasitol Parasit Dis 31: 413–418.
Zhang L, Feng J, Xia ZG, 2014. Malaria situation in the People’s Republic of China in 2013. Chin J Parasitol Parasit Dis 32: 407–413.
Zhang L, Zhou SS, Feng J, Fang W, Xia ZG, 2015. Malaria situation in the People’s Republic of China in 2014. Chin J Parasitol Parasit Dis 33: 319–326.
Zhang L, Feng J, Zhang SS, Xia ZG, Zhou SS, 2016. Malaria situation in the People’s Republic of China in 2015. Chin J Parasitol Parasit Dis 34: 477–481.
Li Z et al.., 2015. Malaria imported from Ghana by returning gold miners, China, 2013. Emerg Infect Dis 21: 864–867.
Feng J, Li J, Yan H, Feng X, Xia Z, 2015. Evaluation of antimalarial resistance marker polymorphism in returned migrant workers in China. Antimicrob Agents Chemother 59: 326–330.
Ling KM, Li J, Yang YC, Wei SJ, Huang YM, Li JH, Guo CK, Wei HY, 2015. Characteristics of imported malaria epidemic in Guangxi, 2013. Mod Prev Med 24: 2439–2442.
Guo CK, Li JH, Jing YX, 2007. Investigation on geographical distribution, ecological feature and malaria transmission of Anopheles in Guangxi. Chin J Vector Bio & Control 18: 112–115.
Wang WM, Zhou HY, Liu YB, Li JL, Zhu GD, Tang JX, Cao YY, Gu YP, 2012. Establishment of early warning system of malaria epidemic situation in Jiangsu Province I impact of temperature on development of Plasmodium vivax in Anopheles sinensis in Jiangsu Province. Chin J Schistosomasis Control 24: 581–584.
National Health and Family Planning Commission, 2016. Technical Regulations for Application of Antimalarials. Beijing, China: National Health and Family Planning Commission.
White NJ, 2011. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J 10: 297.
Battle KE et al.., 2014. Geographical variation in Plasmodium vivax relapse. Malar J 13: 144.
Mao W, Li J, Wei HY, Lin KM, Huang YM, 2013. Long-term effects of artesunate combined with azithromycin on Plasmodium vivax malaria. Chin Trop Med 13: 614–615, 628.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 354 | 354 | 24 |
Full Text Views | 520 | 128 | 1 |
PDF Downloads | 89 | 18 | 1 |