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Dengue Virus Coinfection in Human Immunodeficiency Virus-1-Infected Patients on the West Coast of Mexico

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  • 1 Department of Internal Medicine, University Regional Hospital, Ministry of Health, Colima, Mexico;
  • | 2 School of Medicine, University of Colima, Colima, Mexico;
  • | 3 Cancer State Institute, Ministry of Health, Colima, Mexico;
  • | 4 Department of Emerging Diseases and Emergencies, Institute for Epidemiological Diagnosis and Reference, Ministry of Health, Mexico City, Mexico;
  • | 5 Center for Gene Therapy, Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope, Duarte, California
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Dengue virus infection in human immunodeficiency virus (HIV)-positive patients is not well studied. Previous reports suggest a transitory inhibition of the HIV-1 viral load, as well as a benign clinical progression of dengue. The follow-up of six HIV-1-infected patients, diagnosed and hospitalized with dengue virus infection in the State of Colima, Mexico, was carried out to analyze the progression of this viral coinfection. The presence of dengue virus serotype 1 was confirmed through molecular tests. No severe complications were observed in any of the patients during dengue virus infection. Significant alteration of the HIV-1 viral loads was not observed during dengue virus infection and 6 months after coinfection. Further studies are required to understand the pathology, as well as the clinical course, of these viral coinfections.

Author Notes

Address correspondence to Uriel A. López-Lemus, School of Medicine, University of Colima, Avenida Universidad 333, Las Víboras, Colima, México 28040. E-mail: lemus_a83@yahoo.com

Authors’ addresses: Francisco Espinoza-Gómez and Iván Delgado-Enciso, Department of Public Health, University of Colima, Colima, Mexico, E-mails: fespin@ucol.mx and ivan_delgado_enciso@ucol.mx. Salvador Valle-Reyes, Rodolfo Ochoa-Jiménez, and Uriel A. López-Lemus, Department of Public Health, University of Colima, School of Medicine, Colima, Mexico, E-mails: juanchavador@hotmail.com, docochoa@hotmail.com, and lemus_a83@yahoo.com. Conrado Arechiga-Ramírez and José L. Gámez-Arroyo, Hospital Regional Universitario de Colima, Internal Medicine, Colima, Mexico, E-mails: drpepearechiga@latinmail.com and gamezajl@hotmail.com. Roberto Vázquez-Campuzano and Carmen Guzmán-Bracho, Department of Emerging Diseases and Emergencies, Institute for Epidemiological Diagnosis and Reference, Mexico City, Mexico, E-mails: roberto.vazquez@salud.gob.mx and carmen.guzman@salud.gob.mx. Clemente Vásquez, Department of Biomedical Sciences, University of Colima, Colima, Mexico, E-mail: clemvas@ucol.mx.

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