DoradoEJ et al., 2016. Genetic characterisation of Plasmodium falciparum isolates with deletion of the pfhrp2 and/or pfhrp3 genes in Colombia: The Amazon Region, a challenge for malaria diagnosis and control. SnounouG, ed. PLoS One11: e0163137.
DoradoEJ, 2016. Genetic characterisation of Plasmodium falciparum isolates with deletion of the pfhrp2 and/or pfhrp3 genes in Colombia: The Amazon Region, a challenge for malaria diagnosis and control. SnounouG, ed. PLoS One11: e0163137.)| false
The Caribbean island of Hispaniola is targeted for malaria elimination. Currently, this is the only island with ongoing transmission of malaria in the Caribbean. In 2015, six patients from Puerto Rico and one from Massachusetts, who traveled to Punta Cana, Dominican Republic, were confirmed to be infected with Plasmodium falciparum. Additional molecular analysis was performed at the Centers for Disease Control and Prevention to characterize the drug-resistant alleles and Plasmodium population genetic markers. All specimens carried wildtype genotypes for chloroquine, sulfadoxine-pyrimethamine, and artemisinin resistance genetic markers. A mutation in codon 184 (Y/F) of Pfmdr-1 gene was observed in all samples and they shared an identical genetic lineage as determined by microsatellite analysis. This genetic profile was similar to one previously reported from Hispaniola suggesting that a clonal P. falciparum residual parasite population present in Punta Cana is the source population for these imported malaria cases.
Address correspondence to Venkatachalam Udhayakumar, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Road, MS D-67, Atlanta, GA 30333. E-mail: email@example.com
Financial support: This work was supported by the Centers for Disease Control and Prevention and by the Antimicrobial Resistance Working Group. Stella M. Chenet was supported by the American Society of Microbiology/CDC Postdoctoral Research Fellowship.
Authors’ addresses: Stella M. Chenet, Naomi W. Lucchi, Kimberly Mace, Paul M. Arguin, and Venkatachalam Udhayakumar, Center for Global Health/Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, and firstname.lastname@example.org. Luciana Silva-Flannery and Dragan Ljolje, Atlanta Research and Education Foundation, Decatur, GA, E-mails: email@example.com and firstname.lastname@example.org. Emilio Dirlikov, Puerto Rico Department of Health, San Juan, Puerto Rico, Office of Epidemiology and Research, San Jose, Pueto Rico, and Division of Scientific Education and Professional Development, Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: email@example.com. Brenda Rivera-García, Puerto Rico Department of Health, Epidemiology and Research Office, San Juan, Puerto Rico, E-mail: firstname.lastname@example.org.