A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission

Deyu Huang Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China;
Department of Infectious Diseases, Qilu hospital of Shandong University, Qingdao, People’s Republic of China;

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Yueping Jiang Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China;

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Xiaoping Liu State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Bo Wang State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Junming Shi State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Zhan Su Department of hematology, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China

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Hui Wang Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China;

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Ting Wang Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China;

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Shuang Tang State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Hanyun Liu Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China;

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Zhihong Hu State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Fei Deng State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Shu Shen State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;

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Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of the emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS). SFTSV could be transmitted through tick bite. Transmission of SFTSV among humans has also been reported mainly through direct blood contact. In July 2014, a cluster of six suspected SFTS cases occurred in Shandong Province, China. In this cluster, both symptomatic and asymptomatic persons were included. By analyzing the clinical data and results of laboratory tests, and conducting the epidemiological interviews with the cases and their families, risk factors responsible for the transmission were evaluated. The findings suggested that SFTSV transmission among humans may cause asymptomatic infection via personal contact without blood exposure.

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Author Notes

Address correspondence to Shu Shen, Wuhan Institute of Virology, Chinese Academy of Sciences, Xiaohongshan 44, Wuchang District, Wuhan city, Hubei Province 430071, People’s Republic of China. E-mail: shenshu@wh.iov.cn

Authors’ addresses: Deyu Huang, Department of infectious Diseases, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China, and Department of Infectious Diseases, Qilu Hospital of Shandong University, Qingdao, People’s Republic of China, E-mail: sinba168@sina.com. Yueping Jiang, Hui Wang, Ting Wang, and Hanyun Liu, Department of infectious Disease, Affiliated Hospital of Medical College Qingdao University, Qingdao, People’s Republic of China, E-mails: yuepingmdv@hotmail.com, 18661807190@163.com, papro99@yahoo.com.cn, and irene720@126.com. Xiaoping Liu, Bo Wang, Shuang Tang, Zhihong Hu, Fei Deng, and Shu Shen, State Key Laboratory of Virology, Wuhan Institute of Virology Chinese Academy of Sciences, State Key Laboratory of Virology, Wuhan, People’s Republic of China, E-mail: livxiaop@126.com, bow2012@163.com, ts@wh.iov.cn, huzh@wh.iov.cn, df@wh.iov.cn, and shenshu@wh.iov.cn. Zhan Su, Department of Hematology, Affiliated Hospital of Medical College Qingdao University, Department of hematology, Qingdao, People’s Republic of China, E-mail: hxhgq1988@163.com.

Financial support: This work was supported by the Special Project of The Ministry of Science and Technology (No. 2013FY113500), and the National Science and Technology Major Project of China (No. 2008ZX10002-004, 2012ZX10002003).

  • 1.

    Yu XJ et al.., 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.

  • 2.

    Jiang XL et al.., 2014. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274279.

    • Search Google Scholar
    • Export Citation
  • 3.

    Zhang YZ et al.., 2011. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi 32: 209220.

    • Search Google Scholar
    • Export Citation
  • 4.

    Zhang YZ et al.., 2012. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol 86: 28642868.

  • 5.

    Tang X et al.., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736739.

    • Search Google Scholar
    • Export Citation
  • 6.

    Bao CJ et al.., 2011. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis 53: 12081214.

    • Search Google Scholar
    • Export Citation
  • 7.

    Wang Y, Deng B, Zhang J, Cui W, Yao W, Liu P, 2014. Person-to-person asymptomatic infection of severe fever with thrombocytopenia syndrome virus through blood contact. Intern Med 53: 903906.

    • Search Google Scholar
    • Export Citation
  • 8.

    Gai Z et al.., 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54: 249252.

    • Search Google Scholar
    • Export Citation
  • 9.

    Jiang XL et al.., 2015. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274279.

    • Search Google Scholar
    • Export Citation
  • 10.

    Liu Y, Li Q, Hu W, Wu J, Wang Y, Mei L, Walker DH, Ren J, Wang Y, Yu XJ, 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 12: 156160.

    • Search Google Scholar
    • Export Citation
  • 11.

    Chen H, Hu K, Zou J, Xiao J, 2013. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 17: e206e208.

    • Search Google Scholar
    • Export Citation
  • 12.

    Kim WY et al.., 2015. Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea. Clin Infect Dis 60: 16811683.

  • 13.

    Yoo JR, Heo ST, Park D, Kim H, Fukuma A, Fukushi S, Shimojima M, Lee KH, 2016. Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea. Am J Trop Med Hyg 95: 13511357.

    • Search Google Scholar
    • Export Citation
  • 14.

    Bowen MD, Trappier SG, Sanchez AJ, Meyer RF, Goldsmith CS, Zaki SR, Dunster LM, Peters CJ, Ksiazek TG, Nichol ST, Force RVFT, 2001. A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. Virology 291: 185190.

    • Search Google Scholar
    • Export Citation
  • 15.

    Xu BL et al.., 2011. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new Bunyavirus. PLoS Pathog 7: e1002369.

    • Search Google Scholar
    • Export Citation
  • 16.

    Ning YJ, Wang M, Deng M, Shen S, Liu W, Cao WC, Deng F, Wang YY, Hu Z, Wang H, 2014. Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform. J Mol Cell Biol 6: 324337.

    • Search Google Scholar
    • Export Citation
  • 17.

    Shen S, Wang M, Li X, Li S, van Oers MM, Vlak JM, Braakman I, Hu Z, Deng F, Wang H, 2016. Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus. J Gen Virol 97: 988999.

    • Search Google Scholar
    • Export Citation
  • 18.

    Deitch EA, 1992. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 216: 117134.

  • 19.

    Gai ZT et al.., 2012. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis 206: 10951102.

    • Search Google Scholar
    • Export Citation
  • 20.

    Zhang YZ et al.., 2012. Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis 54: 527533.

    • Search Google Scholar
    • Export Citation
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