• 1.

    Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, Cleret de Langavant L, de Broucker T, Brun-Buisson C, Leparc-Goffart I, Mekontso Dessap A, 2016. Zika virus associated with meningoencephalitis. N Engl J Med 374: 15951596.

    • Search Google Scholar
    • Export Citation
  • 2.

    Mécharles S, Herrmann C, Poullain P, Tran TH, Deschamps N, Mathon G, Landais A, Breurec S, Lannuzel A, 2016. Acute myelitis due to Zika virus infection. Lancet 387: 1481.

    • Search Google Scholar
    • Export Citation
  • 3.

    Dominican Republic Ministry of Public Health, 2016. Weekly Epidemiological Bulletin. EW 48 of 2016. Available at: http://digepisalud.gob.do/docs/Boletines%20epidemiol%C3%B3gicos/Boletines%20semanales/2016/Bolet%C3%ADn%20Se manal%2048-2016.pdf. Accessed February 12, 2017.

    • Search Google Scholar
    • Export Citation
  • 4.

    Pan American Health Organization/World Health Organization, 2016. Zika—Epidemiological Report Dominican Republic. December 2016. Washington, DC: Pan American Health Organization/Geneva, Switzerland: World Health Organization.

    • Search Google Scholar
    • Export Citation
  • 5.

    Gourinat AC, O’connor O, Calvez E, Goarant C, Dupont-rouzeyrol M, 2015. Detection of Zika virus in urine. Emerg Infect Dis 21: 8486.

  • 6.

    Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA, Rose L, Hills S, Wasley A, Fischer M, Powers AM, 2016. Interim guidance for interpretation of zika virus antibody test results. MMWR Morb Mortal Wkly Rep 65: 543546.

    • Search Google Scholar
    • Export Citation
  • 7.

    Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, Ghawche F, 2014. Zika virus infection complicated by Guillain-Barre syndrome–case report, French Polynesia, December 2013. Euro Surveill 19: 20720.

    • Search Google Scholar
    • Export Citation
  • 8.

    Waggoner JJ, Gresh L, Vargas MJ, Ballesteros G, Tellez Y, Soda KJ, Sahoo MK, Nuñez A, Balmaseda A, Harris E, Pinsky BA, 2016. Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus. Clin Infect Dis 63: 15841590.

    • Search Google Scholar
    • Export Citation
  • 9.

    Sarmiento-Ospina A, Vásquez-Serna H, Jimenez-Canizales CE, Villamil-Gómez WE, Rodriguez-Morales AJ, 2016. Zika virus associated deaths in Colombia. Lancet Infect Dis 16: 523524.

    • Search Google Scholar
    • Export Citation
  • 10.

    Sejvar JJ, 2007. The long-term outcomes of human West Nile virus infection. Clin Infect Dis 44: 16171624.

  • 11.

    Speers DJ, Flexman J, Blyth CC, Rooban N, Raby E, Ramaseshan G, Benson S, Smith DW, 2013. Clinical and radiological predictors of outcome for Murray Valley encephalitis. Am J Trop Med Hyg 88: 481489.

    • Search Google Scholar
    • Export Citation
  • 12.

    Fontes CA, Dos Santos AA, Marchiori E, 2016. Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection. Neuroradiology 58: 837838.

    • Search Google Scholar
    • Export Citation
  • 13.

    Mahan M, Karl M, Gordon S, 2014. Neuroimaging of viral infections of the central nervous system. Handb Clin Neurol 123: 149173.

  • 14.

    Handique SK, 2011. Viral infections of the central nervous system. Neuroimaging Clin N Am 21: 777794, vii.

  • 15.

    Vachha B, Rojas R, Prabhu SP, Bhadelia R, Moonis G, 2014. Magnetic resonance imaging in viral and prion diseases of the central nervous system. Top Magn Reson Imaging 23: 293302.

    • Search Google Scholar
    • Export Citation
  • 16.

    Ganguly B, Ganguly E, 2016. Disruption of human astn2 function by ZIKV ns4b gene as a molecular basis for Zika viral microcephaly. bioRxiv 054486.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 12 12 12
Full Text Views 442 126 4
PDF Downloads 148 37 4
 
 
 
 
 
 
 
 
 
 
 

Case Report: Zika Virus Meningoencephalitis and Myelitis and Associated Magnetic Resonance Imaging Findings

Faruq PradhanDepartment of Internal Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Faruq Pradhan in
Current site
Google Scholar
PubMed
Close
,
Joseph D. BurnsDepartment of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Joseph D. Burns in
Current site
Google Scholar
PubMed
Close
,
Ahmed AgameyaDepartment of Internal Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Ahmed Agameya in
Current site
Google Scholar
PubMed
Close
,
Avignat PatelDepartment of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Avignat Patel in
Current site
Google Scholar
PubMed
Close
,
Mohammad AlfaqihDepartment of Radiology, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Mohammad Alfaqih in
Current site
Google Scholar
PubMed
Close
,
Juan E. SmallDepartment of Radiology, Lahey Hospital and Medical Center, Burlington, Massachusetts

Search for other papers by Juan E. Small in
Current site
Google Scholar
PubMed
Close
, and
Winnie OoiDepartment of Infectious Diseases, Lahey Hospital and Medical Centre, Travel and Tropical Medicine Clinic, Burlington, Massachusetts

Search for other papers by Winnie Ooi in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

Zika virus (ZIKV) has a wide clinical spectrum of associated neurologic disease including microcephaly and Guillain–Barre syndrome but, despite its known neurotropism, ZIKV meningoencephalitis and myelitis have been rare complications. We describe a case of ZIKV meningoencephalitis and probable myelitis and its associated magnetic resonance imaging findings that rapidly resolved during recovery in a previously healthy adult.

Author Notes

Address correspondence to Faruq Pradhan, Department of Internal Medicine, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805. E-mail: faruq.pradhan@lahey.org

Authors’ addresses: Faruq Pradhan, Department of Internal Medicine, Lahey Hospital and Medical Center, Burlington, MA, E-mail: faruq.pradhan@lahey.org. Joseph D. Burns, Department of Neurology, Lahey Hospital and Medical Center, Burlington, MA, E-mail: joseph.d.burns@lahey.org. Ahmed Agameya, Department of Internal Medicine, Travel and Tropical Medicine Clinic, Lahey Hospital and Medical Centre, Burlington, MA, E-mail: ahmed.agameya@lahey.org. and Winnie Ooi, Department of Infectious Diseases, Travel and Tropical Medicine Clinic, Lahey Hospital and Medical Centre, Burlington, MA, E-mail: winnie.w.ooi@lahey.org. Avignat Patel, Department of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA, E-mail: avignat.s.patel@lahey.org. Mohammad Alfaqih, Department of Radiology, Lahey Hospital and Medical Center, Burlington, MA, E-mail: mohammad.alfaqih@lahey.org. Juan E. Small, Department of Radiology, Lahey Hospital and Medical Center, Burlington, MA, E-mail: juan.e.small@lahey.org.

Save