ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
White NJ, 1998. Preventing antimalarial drug resistance through combinations. Drug Resist Updat 1: 3–9.
-
2.
Whegang SY, Tahar R, Foumane VN, Soula G, Gwét H, Thalabard JC, Basco LK, 2010. Efficacy of non-artemisinin and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon. Malar J 9: 56.
-
3.
Toure OA, Assi SB, N'Guessan TL, Adji GE, Ako AB, Brou MJ, Ehouman MF, Gnamien LA, Coulibaly MA, Coulibaly B, Beourou S, Bassinka I, Soumahoro A, Kadjo F, Tano MA, 2014. Open-label, randomized, non-inferiority clinical trial of artesunate-amodiaquine versus artemether-lumefantrine fixed-dose combinations in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire. Malar J 13: 439.
-
4.
World Health Organization, 2010. Global Report on Antimalarial Drug Efficacy and Drug Resistance: 2000–2010. Geneva, Switzerland: World Health Organization.
-
5.
Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MMArtemisinin Resistance in Cambodia 1 (ARC1) Study Consortium, 2008. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 359: 2619–2620.
-
6.
Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, Lim P, Mao S, Sopha C, Sam B, Anderson JM, Duong S, Chuor CM, Taylor WRJ, Suon S, Mercereau-Puijalon O, Fairhurst RM, Menard D, 2013. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect Dis 13: 1043–1049.
-
7.
Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR, Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J, Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J, Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M, Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ, Tracking Resistance to Artemisinin Collaboration (TRAC), 2014. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 371: 411–423.
-
8.
Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NTT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV, 2015. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in southeast Asia. J Infect Dis 211: 670–679.
-
9.
Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D, 2014. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505: 50–55.
-
10.
Amaratunga C, Witkowski B, Khim N, Menard D, Fairhurst RM, 2014. Artemisinin resistance in Plasmodium falciparum. Lancet Infect Dis 14: 449–450.
-
11.
Straimer J, Gnädig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, Dacheux M, Khim N, Zhang L, Lam S, Gregory PD, Urnov FD, Mercereau-Puijalon O, Benoit-Vical F, Fairhurst RM, Ménard D, Fidock DA, 2015. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 347: 428–431.
-
12.
Roper C, Alifrangis M, Ariey F, Talisuna A, Menard D, Mercereau-Puijalon O, Ringwald P, 2014. Molecular surveillance for artemisinin resistance in Africa. Lancet Infect Dis 14: 668–670.
-
13.
Mount DL, Nahlen BL, Patchen LC, Churchill FC, 1989. Adaptations of the Saker–Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine. Bull World Health Organ 67: 295–300.
-
14.
Tahar R, Ringwald P, Basco LK, 2009. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am J Trop Med Hyg 81: 13–18.
-
15.
Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Martensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ, 2015. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis 211: 680–688.
-
16.
Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA, 2015. K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa. J Infect Dis 211: 1352–1355.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 651 | 563 | 33 |
| Full Text Views | 419 | 9 | 0 |
| PDF Downloads | 182 | 16 | 0 |
Molecular Epidemiology of Malaria in Cameroon and Côte d'Ivoire. XXXI. Kelch 13 Propeller Sequences in Plasmodium falciparum Isolates before and after Implementation of Artemisinin-Based Combination Therapy
Joseph Allico Djaman
Joseph Allico Djaman
Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire;
Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Dagnogo Olefongo
Dagnogo Olefongo
Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire;
Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Aristide Berenger Ako
Aristide Berenger Ako
Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire;
Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire;
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Jocelyne Roman
Jocelyne Roman
Unité Mixte de la Recherche 216, Mère et Enfant Face aux Infections Tropicales, Institut de Recherche pour le Développement (IRD), Unité de Formation et de Recherche (UFR) de Pharmacie, Université Paris Descartes, Paris, France;
PRES Sorbonne Paris Cité, Université Paris Descartes Faculté de Pharmacie, Paris, France;
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PRES Sorbonne Paris Cité, Université Paris Descartes Faculté de Pharmacie, Paris, France;
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Vincent Foumane Ngane
Vincent Foumane Ngane
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon;
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Leonardo K. Basco
Leonardo K. Basco
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon;
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix-Marseille Université, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France
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Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix-Marseille Université, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France
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Rachida Tahar
Rachida Tahar
Unité Mixte de la Recherche 216, Mère et Enfant Face aux Infections Tropicales, Institut de Recherche pour le Développement (IRD), Unité de Formation et de Recherche (UFR) de Pharmacie, Université Paris Descartes, Paris, France;
PRES Sorbonne Paris Cité, Université Paris Descartes Faculté de Pharmacie, Paris, France;
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon;
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PRES Sorbonne Paris Cité, Université Paris Descartes Faculté de Pharmacie, Paris, France;
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon;
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Artemisinin-resistant malaria has not been reported from Africa, but resistance can possibly spread from Asia or arise independently in Africa. The emergence of artemisinin resistance in Africa can be monitored by molecular assay of Kelch 13 (K13) propeller sequences. A total of 251 archived DNA samples of Plasmodium falciparum isolates collected in 2002, 2003, and 2006 in Yaounde, Cameroon, and 47 samples collected in 2006 and 2013 in Abidjan, Côte d'Ivoire, were analyzed for K13-propeller sequence polymorphism. Only one isolate carried a mutant K13-propeller allele (E602D). None of the isolates carried the key mutant alleles (Y493H, R539T, I543T, and C580Y) associated with artemisinin resistance in Cambodia. The presence of the mutant allele was not correlated with in vitro response to dihydroartemisinin determined by the classical hypoxanthine incorporation assay. There was no evidence of K13 mutations associated with artemisinin resistance before and soon after the introduction of artemisinin-based combination therapies in Cameroon and Côte d'Ivoire.
Author Notes
Financial support: This study was supported by Expertise France (5% Initiative grant) and the WHO Global Fund through the National Program for Malaria Control (Côte d'Ivoire).
Authors' addresses: Joseph Allico Djaman, Dagnogo Olefongo, and Aristide Berenger Ako, Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire, and Département de Parasitologie-Mycologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire. Jocelyne Roman, Unité Mixte de la Recherche 216, Mère et Enfant Face aux Infections Tropicales, Institut de Recherche pour le Développement (IRD), Unité de Formation et de Recherche (UFR) de Pharmacie, Université Paris Descartes, Paris, France, and PRES Sorbonne Paris Cité, Université Paris Descartes Faculté de Pharmacie, Paris, France. Vincent Foumane Ngane, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon. Leonardo K. Basco, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon, and Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix-Marseille Université, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France. Rachida Tahar, Unité Mixte de la Recherche 216, Mère et Enfant Face aux Infections Tropicales, Institut de Recherche pour le Développement (IRD), Unité de Formation et de Recherche (UFR) de Pharmacie, Université Paris Descartes, Paris, France, and Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon, E-mail: rachida.tahar@ird.fr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
White NJ, 1998. Preventing antimalarial drug resistance through combinations. Drug Resist Updat 1: 3–9.
-
2.
Whegang SY, Tahar R, Foumane VN, Soula G, Gwét H, Thalabard JC, Basco LK, 2010. Efficacy of non-artemisinin and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon. Malar J 9: 56.
-
3.
Toure OA, Assi SB, N'Guessan TL, Adji GE, Ako AB, Brou MJ, Ehouman MF, Gnamien LA, Coulibaly MA, Coulibaly B, Beourou S, Bassinka I, Soumahoro A, Kadjo F, Tano MA, 2014. Open-label, randomized, non-inferiority clinical trial of artesunate-amodiaquine versus artemether-lumefantrine fixed-dose combinations in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire. Malar J 13: 439.
-
4.
World Health Organization, 2010. Global Report on Antimalarial Drug Efficacy and Drug Resistance: 2000–2010. Geneva, Switzerland: World Health Organization.
-
5.
Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MMArtemisinin Resistance in Cambodia 1 (ARC1) Study Consortium, 2008. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 359: 2619–2620.
-
6.
Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, Lim P, Mao S, Sopha C, Sam B, Anderson JM, Duong S, Chuor CM, Taylor WRJ, Suon S, Mercereau-Puijalon O, Fairhurst RM, Menard D, 2013. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect Dis 13: 1043–1049.
-
7.
Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR, Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J, Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J, Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M, Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ, Tracking Resistance to Artemisinin Collaboration (TRAC), 2014. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 371: 411–423.
-
8.
Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NTT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV, 2015. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in southeast Asia. J Infect Dis 211: 670–679.
-
9.
Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D, 2014. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505: 50–55.
-
10.
Amaratunga C, Witkowski B, Khim N, Menard D, Fairhurst RM, 2014. Artemisinin resistance in Plasmodium falciparum. Lancet Infect Dis 14: 449–450.
-
11.
Straimer J, Gnädig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, Dacheux M, Khim N, Zhang L, Lam S, Gregory PD, Urnov FD, Mercereau-Puijalon O, Benoit-Vical F, Fairhurst RM, Ménard D, Fidock DA, 2015. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 347: 428–431.
-
12.
Roper C, Alifrangis M, Ariey F, Talisuna A, Menard D, Mercereau-Puijalon O, Ringwald P, 2014. Molecular surveillance for artemisinin resistance in Africa. Lancet Infect Dis 14: 668–670.
-
13.
Mount DL, Nahlen BL, Patchen LC, Churchill FC, 1989. Adaptations of the Saker–Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine. Bull World Health Organ 67: 295–300.
-
14.
Tahar R, Ringwald P, Basco LK, 2009. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am J Trop Med Hyg 81: 13–18.
-
15.
Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Martensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ, 2015. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis 211: 680–688.
-
16.
Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA, 2015. K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa. J Infect Dis 211: 1352–1355.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 651 | 563 | 33 |
| Full Text Views | 419 | 9 | 0 |
| PDF Downloads | 182 | 16 | 0 |