Case Report: Microcephaly in Twins due to the Zika Virus

Victor S. Santos Federal University of Sergipe, Aracaju, Brazil;

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Sheila J. G. Oliveira Federal University of Sergipe, Aracaju, Brazil;

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Ricardo Q. Gurgel Federal University of Sergipe, Aracaju, Brazil;

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Dorothy R. R. Lima Federal University of Sergipe, Aracaju, Brazil;

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Cliomar A. dos Santos Central Public Health Laboratory, Aracaju, Brazil

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Paulo R. S. Martins-Filho Federal University of Sergipe, Aracaju, Brazil;

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Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe abnormalities in the central nervous system due to neural cell destruction and the disruption of the normal development processes of the brain. This case report and other similar twin cases may help to understand the pathogenesis and to confirm the etiology of ZIKV as a teratogenic microorganism.

Author Notes

Address correspondence to Paulo R. S. Martins-Filho, Investigative Pathology Laboratory, University Hospital, Federal University of Sergipe, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, Brazil, CEP 49060-100. E-mail: martins-filho@ufs.br

Authors’ addresses: Victor S. Santos, Sheila J. G. Oliveira, Ricardo Q. Gurgel, Dorothy R. R. Lima, and Paulo R. S. Martins-Filho, Federal University of Sergipe, Aracaju, Brazil, E-mails: santosvictor19@gmail.com, sheilajgsoliveira@gmail.com, ricardoqgurgel@gmail.com, dorothyribeiro@hotmail.com, and martins-filho@ufs.br. Cliomar A. dos Santos, Central Public Health Laboratory, Aracaju, Brazil, E-mail: cliomar.santos@fsph.se.gov.br.

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