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RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Victora CG, Schuler-Faccini L, Matijasevich A, Ribeiro E, Pessoa A, Barros FC, 2016. Microcephaly in Brazil: how to interpret reported numbers? Lancet 387: 621–624.
-
2.
de Noronha L, Zanluca C, Azevedo MLV, Luz KG, dos Santos CND, 2016. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz 111: 287–293.
-
3.
Bhatnagar J, Rabeneck DB, Martines RB, Reagan-Steiner S, Ermias Y, Estetter LBC, Suzuki T, Ritter J, Keating MK, Hale G, Gary J, Muehlenbachs A, Lambert A, Lanciotti R, Oduyebo T, Meaney-Delman D, Bolaños F, Saad EAP, Shieh W-J, Zaki SR, 2017. Zika Virus RNA replication and persistence in brain and placental tissue. Emerg Infect Dis 23: 405–414.
-
4.
Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR, 2016. Zika virus and birth defects: reviewing the evidence for causality. N Engl J Med 374: 1981–1987.
-
5.
Fenton TR, Kim JH, 2013. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr 13: 1–13.
-
6.
Brazil, Ministério da Saúde, 2016. Informe Epidemiológico N° 31—Semana Epidemiológica (SE) 24/2016 (12 a 18/06/2016) Monitoramento dos casos de microcefalia no Brasil. Available at: http://combateaedes.saude.gov.br/images/pdf/informe_microcefalia_epidemiologico31.pdf. Accessed January 7, 2017.
-
7.
de Araujo TVB, Rodrigues LC, de Alencar Ximenes RA, de Barros Miranda-Filho D, Montarroyos UR, de Melo APL, Valongueiro S, de Albuquerque M de FPM, Souza WV, Braga C, Filho SPB, Cordeiro MT, Vazquez E, Di Cavalcanti Souza Cruz D, Henriques CMP, Bezerra LCA, da Silva Castanha PM, Dhalia R, Marques-Junior ETA, Martelli CMT; Investigators from the Microcephaly Epidemic Research Group; Brazilian Ministry of Health; Pan American Health Organization; Instituto de Medicina Integral Professor Fernando Figueira; State Health Department of Pernambuco, 2016. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis 3099: 1–8.
-
8.
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK, 2016. Zika virus impairs growth in human neurospheres and brain organoids. Science 352: 816–818.
-
9.
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JLM, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria D de P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PMDA, Peron JPS, Muotri AR, Beltrão-Braga PCB, 2016. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534: 267–271.
-
10.
de Paula Freitas B, de Oliveira Dias JRJ, Prazeres J, Sacramento GAG, Ko AI, Maia MM, Belfort RJ, 2016. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. JAMA Ophthalmol 134: 529–535.
-
11.
Ventura CV, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, Agra C, Torres VL, van der Linden V, Ramos RC, Rocha MÂW, Silva PS, Ventura LO, Belfort R, 2016. Risk factors associated with the ophthalmoscopic findings identified in infants with presumed Zika virus congenital infection. JAMA Ophthalmol 134: 912–918.
-
12.
Kodati S, Palmore TN, Spellman FA, Cunningham D, Weistrop B, Sen HN, 2016. Bilateral posterior uveitis associated with Zika virus infection. Lancet 6736: 10–11.
-
13.
Bae YJ, Kim JH, Choi BS, Jung C, Kim E, 2013. Brainstem pathways for horizontal eye movement: pathologic correlation with MR imaging. Radiographics 33: 47–59.
-
14.
Strupp M, Hüfner K, Sandmann R, Zwergal A, Dieterich M, Jahn K, Brandt T, 2011. Central oculomotor disturbances and nystagmus: a window into the brainstem and cerebellum. Dtsch Arztebl Int 108: 197–204.
-
15.
Büttner U, Büttner-Ennever JA, 2006. Present concepts of oculomotor organization. Prog Brain Res 151: 1–42.
-
16.
Leal MC, Muniz LF, Ferreira TSA, Santos CM, Almeida LC, Van Der Linden V, Ramos RCF, Rodrigues LC, Neto SSC, 2016. Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection: Brazil, November 2015–May 2016. MMWR Morb Mortal Wkly Rep 65: 917–919.
-
17.
Cohen BE, Durstenfeld A, Roehm PC, 2014. Viral causes of hearing loss: a review for hearing health professionals. Trends Hear 18: 1–17.
-
18.
Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, Staples JE, Fischer M, Peacock G, Oduyebo T, Petersen EE, Zaki S, Moore CA, Rasmussen SA, 2016. Update: interim guidance for the evaluation and management of infants with possible congenital Zika virus infection: United States, August 2016. MMWR Morb Mortal Wkly Rep 65: 870–878.
-
19.
Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF, 2000. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol 11: 283–290.
-
20.
Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E, 2016. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 1: 1–6.
-
21.
Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O’Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B, Schinazi RF, Chakraborty R, Suthar MS, 2016. Zika virus infects human placental macrophages. Cell Host Microbe 20: 83–90.
-
22.
Rosenberg AZ, Yu W, Hill DA, Reyes CA, Schwartz DA, 2016. Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer cell) proliferation and hyperplasia. Arch Pathol Lab Med 141: 43–48.
-
23.
Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S, 2016. Zika virus infection of Hofbauer cells. Am J Reprod Immunol 77: e12613.
-
24.
Nahmias AJ, Panigel M, Schwarts DA, 1994. The eight most frequent blood-borne infectious agents affecting the placenta and fetus: a synoptic review. Trophob Research 8: 193–213.
-
25.
Satosar A, 2004. Histologic correlates of viral and bacterial infection of the placenta associated with severe morbidity and mortality in the newborn. Hum Pathol 35: 536–545.
-
26.
Lazzarotto T, Gabrielli L, Foschini MP, Lanari M, Guerra B, Eusebi V, Landini MP, 2003. Congenital cytomegalovirus infection in twin pregnancies: viral load in the amniotic fluid and pregnancy outcome. Pediatrics 112: 133–137.
-
27.
Egaña-Ugrinovic G, Goncé A, García L, Marcos MA, López M, Nadal A, Figueras F, 2015. Congenital cytomegalovirus infection among twin pairs. J Matern Neonatal Med 29: 3439–3444.
-
28.
Yinon Y, Yagel S, Tepperberg-Dikawa M, Feldman B, Schiff E, Lipitz S, 2006. Prenatal diagnosis and outcome of congenital cytomegalovirus infection in twin pregnancies. BJOG An Int J Obstet Gynaecol 113: 295–300.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 332 | 234 | 20 |
| Full Text Views | 479 | 7 | 0 |
| PDF Downloads | 129 | 10 | 0 |
Case Report: Microcephaly in Twins due to the Zika Virus
Victor S. Santos
Victor S. Santos
Federal University of Sergipe, Aracaju, Brazil;
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Sheila J. G. Oliveira
Sheila J. G. Oliveira
Federal University of Sergipe, Aracaju, Brazil;
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Ricardo Q. Gurgel
Ricardo Q. Gurgel
Federal University of Sergipe, Aracaju, Brazil;
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Dorothy R. R. Lima
Dorothy R. R. Lima
Federal University of Sergipe, Aracaju, Brazil;
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Cliomar A. dos Santos
Cliomar A. dos Santos
Central Public Health Laboratory, Aracaju, Brazil
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Paulo R. S. Martins-Filho
Paulo R. S. Martins-Filho
Federal University of Sergipe, Aracaju, Brazil;
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Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe abnormalities in the central nervous system due to neural cell destruction and the disruption of the normal development processes of the brain. This case report and other similar twin cases may help to understand the pathogenesis and to confirm the etiology of ZIKV as a teratogenic microorganism.
Author Notes
Authors’ addresses: Victor S. Santos, Sheila J. G. Oliveira, Ricardo Q. Gurgel, Dorothy R. R. Lima, and Paulo R. S. Martins-Filho, Federal University of Sergipe, Aracaju, Brazil, E-mails: santosvictor19@gmail.com, sheilajgsoliveira@gmail.com, ricardoqgurgel@gmail.com, dorothyribeiro@hotmail.com, and martins-filho@ufs.br. Cliomar A. dos Santos, Central Public Health Laboratory, Aracaju, Brazil, E-mail: cliomar.santos@fsph.se.gov.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Victora CG, Schuler-Faccini L, Matijasevich A, Ribeiro E, Pessoa A, Barros FC, 2016. Microcephaly in Brazil: how to interpret reported numbers? Lancet 387: 621–624.
-
2.
de Noronha L, Zanluca C, Azevedo MLV, Luz KG, dos Santos CND, 2016. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz 111: 287–293.
-
3.
Bhatnagar J, Rabeneck DB, Martines RB, Reagan-Steiner S, Ermias Y, Estetter LBC, Suzuki T, Ritter J, Keating MK, Hale G, Gary J, Muehlenbachs A, Lambert A, Lanciotti R, Oduyebo T, Meaney-Delman D, Bolaños F, Saad EAP, Shieh W-J, Zaki SR, 2017. Zika Virus RNA replication and persistence in brain and placental tissue. Emerg Infect Dis 23: 405–414.
-
4.
Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR, 2016. Zika virus and birth defects: reviewing the evidence for causality. N Engl J Med 374: 1981–1987.
-
5.
Fenton TR, Kim JH, 2013. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr 13: 1–13.
-
6.
Brazil, Ministério da Saúde, 2016. Informe Epidemiológico N° 31—Semana Epidemiológica (SE) 24/2016 (12 a 18/06/2016) Monitoramento dos casos de microcefalia no Brasil. Available at: http://combateaedes.saude.gov.br/images/pdf/informe_microcefalia_epidemiologico31.pdf. Accessed January 7, 2017.
-
7.
de Araujo TVB, Rodrigues LC, de Alencar Ximenes RA, de Barros Miranda-Filho D, Montarroyos UR, de Melo APL, Valongueiro S, de Albuquerque M de FPM, Souza WV, Braga C, Filho SPB, Cordeiro MT, Vazquez E, Di Cavalcanti Souza Cruz D, Henriques CMP, Bezerra LCA, da Silva Castanha PM, Dhalia R, Marques-Junior ETA, Martelli CMT; Investigators from the Microcephaly Epidemic Research Group; Brazilian Ministry of Health; Pan American Health Organization; Instituto de Medicina Integral Professor Fernando Figueira; State Health Department of Pernambuco, 2016. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis 3099: 1–8.
-
8.
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK, 2016. Zika virus impairs growth in human neurospheres and brain organoids. Science 352: 816–818.
-
9.
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JLM, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria D de P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PMDA, Peron JPS, Muotri AR, Beltrão-Braga PCB, 2016. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534: 267–271.
-
10.
de Paula Freitas B, de Oliveira Dias JRJ, Prazeres J, Sacramento GAG, Ko AI, Maia MM, Belfort RJ, 2016. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. JAMA Ophthalmol 134: 529–535.
-
11.
Ventura CV, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, Agra C, Torres VL, van der Linden V, Ramos RC, Rocha MÂW, Silva PS, Ventura LO, Belfort R, 2016. Risk factors associated with the ophthalmoscopic findings identified in infants with presumed Zika virus congenital infection. JAMA Ophthalmol 134: 912–918.
-
12.
Kodati S, Palmore TN, Spellman FA, Cunningham D, Weistrop B, Sen HN, 2016. Bilateral posterior uveitis associated with Zika virus infection. Lancet 6736: 10–11.
-
13.
Bae YJ, Kim JH, Choi BS, Jung C, Kim E, 2013. Brainstem pathways for horizontal eye movement: pathologic correlation with MR imaging. Radiographics 33: 47–59.
-
14.
Strupp M, Hüfner K, Sandmann R, Zwergal A, Dieterich M, Jahn K, Brandt T, 2011. Central oculomotor disturbances and nystagmus: a window into the brainstem and cerebellum. Dtsch Arztebl Int 108: 197–204.
-
15.
Büttner U, Büttner-Ennever JA, 2006. Present concepts of oculomotor organization. Prog Brain Res 151: 1–42.
-
16.
Leal MC, Muniz LF, Ferreira TSA, Santos CM, Almeida LC, Van Der Linden V, Ramos RCF, Rodrigues LC, Neto SSC, 2016. Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection: Brazil, November 2015–May 2016. MMWR Morb Mortal Wkly Rep 65: 917–919.
-
17.
Cohen BE, Durstenfeld A, Roehm PC, 2014. Viral causes of hearing loss: a review for hearing health professionals. Trends Hear 18: 1–17.
-
18.
Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, Staples JE, Fischer M, Peacock G, Oduyebo T, Petersen EE, Zaki S, Moore CA, Rasmussen SA, 2016. Update: interim guidance for the evaluation and management of infants with possible congenital Zika virus infection: United States, August 2016. MMWR Morb Mortal Wkly Rep 65: 870–878.
-
19.
Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF, 2000. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol 11: 283–290.
-
20.
Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E, 2016. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 1: 1–6.
-
21.
Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O’Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B, Schinazi RF, Chakraborty R, Suthar MS, 2016. Zika virus infects human placental macrophages. Cell Host Microbe 20: 83–90.
-
22.
Rosenberg AZ, Yu W, Hill DA, Reyes CA, Schwartz DA, 2016. Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer cell) proliferation and hyperplasia. Arch Pathol Lab Med 141: 43–48.
-
23.
Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S, 2016. Zika virus infection of Hofbauer cells. Am J Reprod Immunol 77: e12613.
-
24.
Nahmias AJ, Panigel M, Schwarts DA, 1994. The eight most frequent blood-borne infectious agents affecting the placenta and fetus: a synoptic review. Trophob Research 8: 193–213.
-
25.
Satosar A, 2004. Histologic correlates of viral and bacterial infection of the placenta associated with severe morbidity and mortality in the newborn. Hum Pathol 35: 536–545.
-
26.
Lazzarotto T, Gabrielli L, Foschini MP, Lanari M, Guerra B, Eusebi V, Landini MP, 2003. Congenital cytomegalovirus infection in twin pregnancies: viral load in the amniotic fluid and pregnancy outcome. Pediatrics 112: 133–137.
-
27.
Egaña-Ugrinovic G, Goncé A, García L, Marcos MA, López M, Nadal A, Figueras F, 2015. Congenital cytomegalovirus infection among twin pairs. J Matern Neonatal Med 29: 3439–3444.
-
28.
Yinon Y, Yagel S, Tepperberg-Dikawa M, Feldman B, Schiff E, Lipitz S, 2006. Prenatal diagnosis and outcome of congenital cytomegalovirus infection in twin pregnancies. BJOG An Int J Obstet Gynaecol 113: 295–300.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 332 | 234 | 20 |
| Full Text Views | 479 | 7 | 0 |
| PDF Downloads | 129 | 10 | 0 |