Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pan American Health Organization World Health Organization, 2013. Epidemiological Alert: Hantavirus Pulmonary Syndrome (HPS). October 17, 2013. Available at: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&gid=23388&Itemid=270. Accessed September 15, 2016.
-
2.
Figueiredo LT, Souza WM, Ferrés M, Enria DA, 2014. Hantaviruses and cardiopulmonary syndrome in South America. Virus Res 187: 43–54.
-
3.
World Health Organization (WHO), 2013. Sustaining the Drive to Overcome the Global Impact of Neglected Tropical Diseases: Second WHO Report on Neglected Diseases. Geneva, Switzerland: WHO.
-
4.
Akiner MM, Demirci B, Babuadze G, Robert V, Schaffner F, 2016. Spread of the invasive mosquitoes Aedes aegypti and Aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in Europe. PLoS Negl Trop Dis 10: 1–5.
-
5.
Secretaria de Vigilância em Saúde/Ministério da Saúde (SVS/MS), 2016. Monitoramento dos Casos de Dengue, febre de Chikungunya e Febre Pelo Vírus Zika até a Semana Epidemiológica 37 de 2016. Boletim Epidemiológico Volume 47 - n° 34. Brasília: SVS/MS.
-
6.
Secretaria de Vigilância em Saúde/Ministério da Saúde (SVS/MS), 2014. Monitoramento dos Casos de Dengue Semana Epidemiológica (SE) 35 e Febre de Chikungunya SE 36 de 2014. Boletim Epidemiológico. Volume 45 - n° 20. Brasília: SVS/MS.
-
7.
Oliveira RC, Guterres A, Fernandes J, D'Andrea PS, Bonvicino CR, de Lemos ER, 2014. Hantavirus reservoirs: current status with an emphasis on data from Brazil. Viruses 29: 1929–1973.
-
8.
Brazilian Ministry of Health, 2016. Confirmed Cases of Hantavirus Diseases. Brazil, Major Regions and Federative Units, 1993 to 2016. Available at: http://portalsaude.saude.gov.br/index.php/o-ministerio/principal/secretarias/svs/hantavirose. Accessed July 20, 2016.
-
9.
Oliveira RC, Cordeiro-Santos M, Guterres A, Fernandes J, de Melo AX, João GA, Novais MA, Travassos da Rosa ES, Vasconcelos PF, Vilges de Oliveira S, de Albuquerque BC, de Lemos ER, 2014. Rio Mamoré virus and hantavirus pulmonary syndrome, Brazil. Emerg Infect Dis 20: 1568–1570.
-
10.
Raboni SM, Levis S, Rosa ES, Bisordi I, Delfraro A, Lemos E, Correia DC, Duarte dos Santos CN, 2007. Hantavirus infection in Brazil: development and evaluation of an enzyme immunoassay and immunoblotting based on N recombinant protein. Diagn Microbiol Infect Dis 58: 89–97.
-
11.
Bonvicino CR, Otazú IB, Vilela JF, 2005. Karyologic and molecular analysis of Proechimys Allen, 1899 (Rodentia, Echimyidae) from the Amazonian region. Arq Mus Nac (Rio de Janeiro) 63: 191–200.
-
12.
Bonvicino CR, 2011. Diversidade cariotipica em roedores Akodontini do Brasil. Bol Soc Bras Mastozoologia 62: 7–11.
-
13.
Padula PJ, Rossi CM, Della Valle MO, Martínez PV, Colavecchia SB, Edelstein A, Miguel SD, Rabinovich RD, Segura EL, 2000. Development and evaluation of solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 49: 149–155.
-
14.
Guterres A, de Oliveira RC, Fernandes J, Schrago CG, de Lemos ER, 2015. Detection of different South American hantaviruses. Virus Res 210: 106–113.
-
15.
Chu YK, Goodin D, Owen RD, Koch D, Jonsson CB, 2009. Sympatry of 2 hantavirus strains, paraguay, 2003–2007. Emerg Infect Dis 15: 1977–1980.
-
16.
Oliveira RC, Teixeira BR, Mello FC, Pereira AP, Duarte AS, Bonaldo MC, Bonvicino CR, D'Andrea PS, Lemos ER, 2009. Genetic characterization of a Juquitiba-like viral lineage in Oligoryzomys nigripes in Rio de Janeiro, Brazil. Acta Trop 112: 212–218.
-
17.
Oliveira RC, Padula PJ, Gomes R, Martinez VP, Bellomo C, Bonvicino CR, Freire e Lima DI, Bragagnolo C, Caldas AC, D'Andrea PS, de Lemos ER, 2011. Genetic characterization of hantaviruses associated with sigmodontine rodents in an endemic area for hantavirus pulmonary syndrome in southern Brazil. Vector Borne Zoonotic Dis 11: 301–314.
-
18.
Sobreira M, Souza GT, Moreli ML, Borges AA, Morais FA, Figueiredo LT, Almeida AM, 2008. A serosurvey for hantavirus infection in wild rodents from the states of Rio de Janeiro and Pernambuco, Brazil. Acta Trop 107: 150–152.
-
19.
Raboni SM, Hoffmann FG, Oliveira RC, Teixeira BR, Bonvicino CR, Stella V, Carstensen S, Bordignon J, D'Andrea PS, Lemos ER, Duarte dos Santos CN, 2009. Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil). J Gen Virol 90: 2166–2171.
-
20.
Oliveira RC, Gentile R, Guterres A, Fernandes J, Teixeira BR, Vaz V, Valdez FP, Vicente LH, da Costa-Neto SF, Bonvicino C, D'Andrea PS, Lemos ER, 2014. Ecological study of hantavirus infection in wild rodents in an endemic area in Brazil. Acta Trop 131: 1–10.
-
21.
Teixeira BR, Loureiro N, Strecht L, Gentile R, Oliveira RC, Guterres A, Fernandes J, Mattos LH, Raboni SM, Rubio G, Bonvicino CR, dos Santos CN, Lemos ER, D'Andrea OS, 2014. Population ecology of hantavirus rodent hosts in southern Brazil. Am J Trop Med Hyg 91: 249–257.
-
22.
Guterres A, de Oliveira RC, Fernandes J, Strecht L, Casado F, Gomes de Oliveira FC, D'Andrea PS, Bonvicino CR, Schrago CG, de Lemos ER Sampaio, 2014. Characterization of Juquitiba virus in Oligoryzomys fornesi from Brazilian Cerrado. Viruses 6: 1473–1482.
-
23.
Umetsu F, Pardini R, 2007. Small mammals in a mosaic of forest remnants and anthropogenic habitats—evaluating matrix quality in an Atlantic forest landscape. Landsc Ecol 22: 517–530.
-
24.
Guterres A, de Oliveira RC, Fernandes J, D'Andrea PS, Bonvicino CR, Bragagnolo C, Guimarães GD, Almada GL, Machado RR, Lavocat M, Elkhoury Mda R, Schrago CG, de Lemos ER, 2013. Phylogenetic analysis of the S segment from Juquitiba hantavirus: identification of two distinct lineages in Oligoryzomys nigripes .Infect Genet Evol 18: 262–268.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 331 | 209 | 21 |
| Full Text Views | 450 | 11 | 0 |
| PDF Downloads | 156 | 14 | 0 |
A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil
Renata Carvalho de Oliveira
Renata Carvalho de Oliveira
Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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Alexandro Guterres
Alexandro Guterres
Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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Bernardo Rodrigues Teixeira
Bernardo Rodrigues Teixeira
Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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Jorlan Fernandes
Jorlan Fernandes
Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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João Marcos Penna Júnior
João Marcos Penna Júnior
Secretaria Municipal de Saúde, Setor de Vigilância Epidemiológica Rio Claro, Rio de Janeiro, Brasil;
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Reynaldo de Jesus Oliveira Júnior
Reynaldo de Jesus Oliveira Júnior
Secretaria Municipal de Saúde, Setor de Vigilância Epidemiológica Rio Claro, Rio de Janeiro, Brasil;
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Liana Strecht Pereira
Liana Strecht Pereira
Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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João Bosco Júnior
João Bosco Júnior
Secretaria Municipal de Saúde, Setor de Vigilância Epidemiológica Rio Claro, Rio de Janeiro, Brasil;
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Patrícia Soares Meneguete
Patrícia Soares Meneguete
Secretaria de Saúde do Estado do Rio de Janeiro, Setor de Vigilância Epidemiológica, Rio de Janeiro, Rio de Janeiro, Brasil
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Cristina Maria Giordano Dias
Cristina Maria Giordano Dias
Secretaria de Saúde do Estado do Rio de Janeiro, Setor de Vigilância Epidemiológica, Rio de Janeiro, Rio de Janeiro, Brasil
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Cibele Rodrigues Bonvicino
Cibele Rodrigues Bonvicino
Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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Paulo Sérgio D'Andrea
Paulo Sérgio D'Andrea
Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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Elba Regina Sampaio de Lemos
Elba Regina Sampaio de Lemos
Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil;
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We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. Antibody prevalence was 6.9%. The circulation of a single genotype, the Juquitiba hantavirus, carried by two rodent species, black-footed pigmy rice rat (Oligoryzomys nigripes) and cursor grass mouse (Akodon cursor), was shown by analysis of the nucleotide sequences of the S segment. Juquitiba hantavirus circulates in rodents of various species, but mainly in the black-footed pigmy rice rat. HPS is a newly recognized clinical entity in Rio de Janeiro State and should be considered in patients with febrile illness and acute respiratory distress.
Author Notes
Financial support: This work was supported by Conselho Nacional para o Desenvolvimento Cientifico e Tecnológico (CNPq)—PAPES VI/FIOCRUZ (grant number: 407664/2012-2).
Authors' addresses: Renata Carvalho de Oliveira, Alexandro Guterres, Jorlan Fernandes, Liana Strecht Pereira, and Elba Regina Sampaio de Lemos, Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil, E-mails: reoliveira@ioc.fiocruz.br, guterres@ioc.fiocruz.br, jorlan@ioc.fiocruz.br, liastrecht@gmail.com, and elemos@ioc.fiocruz.br. Bernardo Rodrigues Teixeira, Cibele Rodrigues Bonvicino, and Paulo Sérgio D`Andrea, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz Rio (FIOCRUZ), Rio de Janeiro, Brazil, E-mails: brt@ioc.fiocruz.br, cibelerb@inca.gov.br, and dandrea@ioc.fiocruz.br. João Marcos Penna Júnior, Reynaldo de Jesus Oliveira Júnior, and João Bosco Júnior, Secretaria Municipal de Saúde, Setor de Vigilância Epidemiológica, Rio Claro, Rio de Janeiro, Brazil, E-mails: marquinhopenna@yahoo.com.br, enf.reynaldo@gmail.com, and drjoaoboscojr@gmail.com. Patrícia Soares Meneguete and Cristina M. Giordano Dias, Secretaria de Saúde do Estado do Rio de Janeiro, Setor de Vigilância Epidemiológica, Rio de Janeiro, Rio de Janeiro, Brazil, E-mails: patricia.meneguete@saude.rj.gov.br and cristina.giordano@saude.rj.gov.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pan American Health Organization World Health Organization, 2013. Epidemiological Alert: Hantavirus Pulmonary Syndrome (HPS). October 17, 2013. Available at: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&gid=23388&Itemid=270. Accessed September 15, 2016.
-
2.
Figueiredo LT, Souza WM, Ferrés M, Enria DA, 2014. Hantaviruses and cardiopulmonary syndrome in South America. Virus Res 187: 43–54.
-
3.
World Health Organization (WHO), 2013. Sustaining the Drive to Overcome the Global Impact of Neglected Tropical Diseases: Second WHO Report on Neglected Diseases. Geneva, Switzerland: WHO.
-
4.
Akiner MM, Demirci B, Babuadze G, Robert V, Schaffner F, 2016. Spread of the invasive mosquitoes Aedes aegypti and Aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in Europe. PLoS Negl Trop Dis 10: 1–5.
-
5.
Secretaria de Vigilância em Saúde/Ministério da Saúde (SVS/MS), 2016. Monitoramento dos Casos de Dengue, febre de Chikungunya e Febre Pelo Vírus Zika até a Semana Epidemiológica 37 de 2016. Boletim Epidemiológico Volume 47 - n° 34. Brasília: SVS/MS.
-
6.
Secretaria de Vigilância em Saúde/Ministério da Saúde (SVS/MS), 2014. Monitoramento dos Casos de Dengue Semana Epidemiológica (SE) 35 e Febre de Chikungunya SE 36 de 2014. Boletim Epidemiológico. Volume 45 - n° 20. Brasília: SVS/MS.
-
7.
Oliveira RC, Guterres A, Fernandes J, D'Andrea PS, Bonvicino CR, de Lemos ER, 2014. Hantavirus reservoirs: current status with an emphasis on data from Brazil. Viruses 29: 1929–1973.
-
8.
Brazilian Ministry of Health, 2016. Confirmed Cases of Hantavirus Diseases. Brazil, Major Regions and Federative Units, 1993 to 2016. Available at: http://portalsaude.saude.gov.br/index.php/o-ministerio/principal/secretarias/svs/hantavirose. Accessed July 20, 2016.
-
9.
Oliveira RC, Cordeiro-Santos M, Guterres A, Fernandes J, de Melo AX, João GA, Novais MA, Travassos da Rosa ES, Vasconcelos PF, Vilges de Oliveira S, de Albuquerque BC, de Lemos ER, 2014. Rio Mamoré virus and hantavirus pulmonary syndrome, Brazil. Emerg Infect Dis 20: 1568–1570.
-
10.
Raboni SM, Levis S, Rosa ES, Bisordi I, Delfraro A, Lemos E, Correia DC, Duarte dos Santos CN, 2007. Hantavirus infection in Brazil: development and evaluation of an enzyme immunoassay and immunoblotting based on N recombinant protein. Diagn Microbiol Infect Dis 58: 89–97.
-
11.
Bonvicino CR, Otazú IB, Vilela JF, 2005. Karyologic and molecular analysis of Proechimys Allen, 1899 (Rodentia, Echimyidae) from the Amazonian region. Arq Mus Nac (Rio de Janeiro) 63: 191–200.
-
12.
Bonvicino CR, 2011. Diversidade cariotipica em roedores Akodontini do Brasil. Bol Soc Bras Mastozoologia 62: 7–11.
-
13.
Padula PJ, Rossi CM, Della Valle MO, Martínez PV, Colavecchia SB, Edelstein A, Miguel SD, Rabinovich RD, Segura EL, 2000. Development and evaluation of solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 49: 149–155.
-
14.
Guterres A, de Oliveira RC, Fernandes J, Schrago CG, de Lemos ER, 2015. Detection of different South American hantaviruses. Virus Res 210: 106–113.
-
15.
Chu YK, Goodin D, Owen RD, Koch D, Jonsson CB, 2009. Sympatry of 2 hantavirus strains, paraguay, 2003–2007. Emerg Infect Dis 15: 1977–1980.
-
16.
Oliveira RC, Teixeira BR, Mello FC, Pereira AP, Duarte AS, Bonaldo MC, Bonvicino CR, D'Andrea PS, Lemos ER, 2009. Genetic characterization of a Juquitiba-like viral lineage in Oligoryzomys nigripes in Rio de Janeiro, Brazil. Acta Trop 112: 212–218.
-
17.
Oliveira RC, Padula PJ, Gomes R, Martinez VP, Bellomo C, Bonvicino CR, Freire e Lima DI, Bragagnolo C, Caldas AC, D'Andrea PS, de Lemos ER, 2011. Genetic characterization of hantaviruses associated with sigmodontine rodents in an endemic area for hantavirus pulmonary syndrome in southern Brazil. Vector Borne Zoonotic Dis 11: 301–314.
-
18.
Sobreira M, Souza GT, Moreli ML, Borges AA, Morais FA, Figueiredo LT, Almeida AM, 2008. A serosurvey for hantavirus infection in wild rodents from the states of Rio de Janeiro and Pernambuco, Brazil. Acta Trop 107: 150–152.
-
19.
Raboni SM, Hoffmann FG, Oliveira RC, Teixeira BR, Bonvicino CR, Stella V, Carstensen S, Bordignon J, D'Andrea PS, Lemos ER, Duarte dos Santos CN, 2009. Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil). J Gen Virol 90: 2166–2171.
-
20.
Oliveira RC, Gentile R, Guterres A, Fernandes J, Teixeira BR, Vaz V, Valdez FP, Vicente LH, da Costa-Neto SF, Bonvicino C, D'Andrea PS, Lemos ER, 2014. Ecological study of hantavirus infection in wild rodents in an endemic area in Brazil. Acta Trop 131: 1–10.
-
21.
Teixeira BR, Loureiro N, Strecht L, Gentile R, Oliveira RC, Guterres A, Fernandes J, Mattos LH, Raboni SM, Rubio G, Bonvicino CR, dos Santos CN, Lemos ER, D'Andrea OS, 2014. Population ecology of hantavirus rodent hosts in southern Brazil. Am J Trop Med Hyg 91: 249–257.
-
22.
Guterres A, de Oliveira RC, Fernandes J, Strecht L, Casado F, Gomes de Oliveira FC, D'Andrea PS, Bonvicino CR, Schrago CG, de Lemos ER Sampaio, 2014. Characterization of Juquitiba virus in Oligoryzomys fornesi from Brazilian Cerrado. Viruses 6: 1473–1482.
-
23.
Umetsu F, Pardini R, 2007. Small mammals in a mosaic of forest remnants and anthropogenic habitats—evaluating matrix quality in an Atlantic forest landscape. Landsc Ecol 22: 517–530.
-
24.
Guterres A, de Oliveira RC, Fernandes J, D'Andrea PS, Bonvicino CR, Bragagnolo C, Guimarães GD, Almada GL, Machado RR, Lavocat M, Elkhoury Mda R, Schrago CG, de Lemos ER, 2013. Phylogenetic analysis of the S segment from Juquitiba hantavirus: identification of two distinct lineages in Oligoryzomys nigripes .Infect Genet Evol 18: 262–268.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 331 | 209 | 21 |
| Full Text Views | 450 | 11 | 0 |
| PDF Downloads | 156 | 14 | 0 |