Impact of a Food Safety Campaign on Streptococcus suis Infection in Humans in Thailand

Dan Takeuchi Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Search for other papers by Dan Takeuchi in
Current site
Google Scholar
PubMed
Close
,
Anusak Kerdsin Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Campus, Sakon Nakhon, Thailand.

Search for other papers by Anusak Kerdsin in
Current site
Google Scholar
PubMed
Close
,
Yukihiro Akeda Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, Osaka, Japan.

Search for other papers by Yukihiro Akeda in
Current site
Google Scholar
PubMed
Close
,
Piphat Chiranairadul Phayao Provincial Hospital, Phayao, Thailand.

Search for other papers by Piphat Chiranairadul in
Current site
Google Scholar
PubMed
Close
,
Phacharaphan Loetthong Phayao Provincial Hospital, Phayao, Thailand.

Search for other papers by Phacharaphan Loetthong in
Current site
Google Scholar
PubMed
Close
,
Nutchada Tanburawong Phayao Provincial Hospital, Phayao, Thailand.

Search for other papers by Nutchada Tanburawong in
Current site
Google Scholar
PubMed
Close
,
Prasanee Areeratana Chiang Kham General Hospital, Phayao, Thailand.

Search for other papers by Prasanee Areeratana in
Current site
Google Scholar
PubMed
Close
,
Panarat Puangmali Chiang Kham General Hospital, Phayao, Thailand.

Search for other papers by Panarat Puangmali in
Current site
Google Scholar
PubMed
Close
,
Kasean Khamisara Chiang Kham General Hospital, Phayao, Thailand.

Search for other papers by Kasean Khamisara in
Current site
Google Scholar
PubMed
Close
,
Wirasinee Pinyo Chiang Kham General Hospital, Phayao, Thailand.

Search for other papers by Wirasinee Pinyo in
Current site
Google Scholar
PubMed
Close
,
Rapeepun Anukul Chiang Kham General Hospital, Phayao, Thailand.

Search for other papers by Rapeepun Anukul in
Current site
Google Scholar
PubMed
Close
,
Sutit Samerchea Phayao Public Health Office, Phayao, Thailand.

Search for other papers by Sutit Samerchea in
Current site
Google Scholar
PubMed
Close
,
Punpong Lekhalula Food Safety Operation Center, Nonthaburi, Thailand.

Search for other papers by Punpong Lekhalula in
Current site
Google Scholar
PubMed
Close
,
Tatsuya Nakayama Global Collaboration Center, Osaka University, Osaka, Japan.

Search for other papers by Tatsuya Nakayama in
Current site
Google Scholar
PubMed
Close
,
Kouji Yamamoto Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka, Japan.

Search for other papers by Kouji Yamamoto in
Current site
Google Scholar
PubMed
Close
,
Masayo Hirose Institute of Statistical Mathematics, Tokyo, Japan.

Search for other papers by Masayo Hirose in
Current site
Google Scholar
PubMed
Close
,
Shigeyuki Hamada Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Search for other papers by Shigeyuki Hamada in
Current site
Google Scholar
PubMed
Close
,
Surang Dejsirilert National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.

Search for other papers by Surang Dejsirilert in
Current site
Google Scholar
PubMed
Close
, and
Kazunori Oishi Infectious Disease Surveillance Center, National Institute of Infectious Disease, Tokyo, Japan.

Search for other papers by Kazunori Oishi in
Current site
Google Scholar
PubMed
Close
Restricted access

Streptococcus suis is an important zoonotic pathogen in swine and humans that causes sepsis and meningitis. Our previous study in Thailand showed that the prevalence of S. suis infection in humans, especially in northern areas of Thailand, and the transmission of the pathogen occurred mainly through the consumption of traditional raw pork products. Considering the high incidence proportion and mortality rate of the disease as an important public health problem, we implemented a food safety campaign in the Phayao Province in northern Thailand in 2011. We evaluated the effects of a food safety campaign by comparing the sociodemographic, clinical, and bacteriological characteristics of cases before and after the campaign. The follow-up study showed a marked decrease of the incidence proportion in the first 2 years, indicating the effectiveness of the campaign. In the third year, however, the incidence proportion slightly increased again, indicating the existence of deep-rooted cultural behaviors and the necessity of continuous public health intervention. Furthermore, epidemiological analysis of the cases made it possible to estimate the infectivity of the pathogen via the oral route of infection. In the present study, we showed the effectiveness of the food safety campaign for controlling the S. suis infection, and we present a role model public health intervention for prevalent areas affected by S. suis infection in humans.

    • Supplemental Materials (PDF KB)

Author Notes

* Address correspondence to Dan Takeuchi, Section of Bacterial Drug Resistance Research, Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan 565-0871, E-mail: dantake@biken.osaka-u.ac.jp or Yukihiro Akeda, Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan 565-0871, E-mail: akeda@hp-infect.med.osaka-u.ac.jp.

Financial support: We thank the Department of Medical Sciences, Ministry of Public Health of Thailand, Japan Society for the Promotion of Science (KAKENHI 21406027), and Japan Initiative for a Global Research Network on Infectious Diseases launched by the Ministry of Education, Science, and Culture of Japan for providing financial support for this work.

Authors' addresses: Dan Takeuchi and Shigeyuki Hamada, Section of Bacterial Drug Resistance Research, Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, E-mails: dantake@biken.osaka-u.ac.jp and hamadas@biken.osaka-u.ac.jp. Anusak Kerdsin, Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Campus, Sakon Nakhon, Thailand, E-mail: noksak99@gmail.com. Yukihiro Akeda, Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, Osaka, Japan, E-mail: akeda@hp-infect.med.osaka-u.ac.jp. Piphat Chiranairadul, Phacharaphan Loetthong, and Nutchada Tanburawong, Phayao Provincial Hospital, Phayao, Thailand, E-mails: ayapiphat@yahoo.com, phacha0037@gmail.com, and wnithita@yahoo.com. Prasanee Areeratana, Panarat Puangmali, Kasean Khamisara, Wirasinee Pinyo, and Rapeepun Anukul, Chiang Kham General Hospital, Phayao, Thailand, E-mails: lekprass2@hotmail.com, puangli_1@hotmail.com, kasian04@hotmail.com, wirasinee_loy@hotmail.com, and ra.peepan111@hotmail.com. Sutit Samerchea, Phayao Public Health Office, Phayao, Thailand, E-mail: sutit2007@hotmail.com. Punpong Lekhalula, Food Safety Operation Center, Nonthaburi, Thailand, E-mail: punpong.fsoc@gmail.com. Tatsuya Nakayama, Global Collaboration Center, Osaka University, Osaka, Japan, E-mail: t.nakayama-glocol@outlook.com. Kouji Yamamoto, Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka, Japan, E-mail: yamamoto-k@stat.med.osaka-u.ac.jp. Masayo Hirose, Institute of Statistical Mathematics, Tokyo, Japan, E-mail: masayo@ism.ac.jp. Surang Dejsirilert, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand, E-mail: surang_dej@yahoo.com. Kazunori Oishi, Infectious Disease Surveillance Center, National Institute of Infectious Disease, Tokyo, Japan, E-mail: oishik@nih.go.jp.

  • 1.

    Kerdsin A, Akeda Y, Hatrongjit R, Detchawna U, Sekizaki T, Hamada S, Gottschalk M, Oishi K, 2014. Streptococcus suis serotyping by a new multiplex PCR. J Med Microbiol 63: 824830.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Huong VT, Ha N, Huy NT, Horby P, Nghia HD, Thiem VD, Zhu X, Hoa NT, Hien TT, Zamora J, Schultsz C, Wertheim HF, Hirayama K, 2014. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis 20: 11051114.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Gottschalk M, Xu J, Calzas C, Segura M, 2010. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol 5: 371391.

  • 4.

    Kerdsin A, Dejsirilert S, Puangpatra P, Sripakdee S, Chumla K, Boonkerd N, Polwichai P, Tanimura S, Takeuchi D, Nakayama T, Nakamura S, Akeda Y, Gottschalk M, Sawanpanyalert P, Oishi K, 2011. Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand. Emerg Infect Dis 17: 835842.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Luangsuk P, Khamisara K, Wongwan N, Areeratana P, Chiranairadul P, Lertchayanti S, Petcharat S, Yowang A, Chaiwongsaen P, Nakayama T, Akeda Y, Hamada S, Sawanpanyalert P, Dejsirilert S, Oishi K, 2012. Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand. PLoS One 7: e31265.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Thailand Provincial Administration Department, Ministry of Interior. Available at: http://www.dopa.go.th. Accessed October 27, 2015.

    • PubMed
    • Export Citation
  • 7.

    Phayao Meteorological Station, Thai Meteorological Department, Ministry of Information and Communication Technology. Available at: http://www.cmmet.tmd.go.th/station/phayao/. Accessed October 27, 2015.

    • PubMed
    • Export Citation
  • 8.

    Nakai S, 2009. Analysis of pig consumption by smallholders in a hillside swidden agriculture society of northern Thailand. Hum Ecol 37: 501511.

  • 9.

    Wangsomboonsiri W, Luksananun T, Saksornchai S, Ketwong K, Sungkanuparph S, 2008. Streptococcus suis infection and risk factors for mortality. J Infect 57: 392396.

  • 10.

    Semenza JC, Menne B, 2009. Climate change and infectious diseases in Europe. Lancet Infect Dis 9: 365375.

  • 11.

    Cheung PY, Lo KL, Cheung TT, Yeung WH, Leung PH, Kam KM, 2008. Streptococcus suis in retail markets: how prevalent is it in raw pork? Int J Food Microbiol 127: 316320.

  • 12.

    Kerdsin A, Dejsirilert S, Sawanpanyalert P, Boonnark A, Noithachang W, Sriyakum D, Simkum S, Chokngam S, Gottschalk M, Akeda Y, Oishi K, 2011. Sepsis and spontaneous bacterial peritonitis in Thailand. Lancet 378: 960.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K, 2013. Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections. Microb Pathog 65: 1420.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Khadthasrima N, Hannwong T, Thammawitjawa P, Pingsusean D, Akkanij B, Jaikhar A, Paungmali P, Yudee P, Wongyai S, Samerchea S, Tipsriraj S, Pruksakorn S, Sutdan D, Noimoh T, Chalamaat M, Samitsuwan P, Chuxnum T, Areechokchai D, 2008. Human Streptococcus suis outbreak in Phayao Province, Thailand, 2007. OSIR 1: 47.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Kerdsin A, Oishi K, Sripakdee S, Boonkerd N, Polwichai P, Nakamura S, Uchida R, Sawanpanyalert P, Dejsirilert S, 2009. Clonal dissemination of human isolates of Streptococcus suis serotype 14 in Thailand. J Med Microbiol 58: 15081513.

    • PubMed
    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 314 272 34
Full Text Views 647 29 1
PDF Downloads 304 21 1
 
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save