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Reference Manager
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-
1.
Wiersinga WJ, Currie BJ, Peacock SJ, 2012. Melioidosis. N Engl J Med 367: 1035–1044.
-
2.
Cheng AC, Currie BJ, 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
3.
Centers for Disease Control and Prevention (CDC) Department of Health and Human Services (HHS), 2012. Possession, use, and transfer of select agents and toxins; biennial review. Final rule. Fed Regist 77: 61083–61115.
-
4.
Wiersinga WJ, de Vos AF, de Beer R, Wieland CW, Roelofs JJ, Woods DE, van der Poll T, 2008. Inflammation patterns induced by different Burkholderia species in mice. Cell Microbiol 10: 81–87.
-
5.
Brett PJ, DeShazer D, Woods DE, 1998. Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species. Int J Syst Bacteriol 48: 317–320.
-
6.
Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ, 2006. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol 4: 272–282.
-
7.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW, 2011. A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science 334: 821–824.
-
8.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
9.
Limmathurotsakul D, Golding N, Dance DAB, Messina JP, Pigott DM, Moyes CL, Rolim DB, Bertherat E, Day NP, Peacock SJ, Hay SI, 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
10.
Birnie E, Wiersinga WJ, Limmathurotsakul D, Grobusch MP, 2015. Melioidosis in Africa: should we be looking more closely? Future Microbiol 10: 273–281.
-
11.
Katangwe T, Purcell J, Bar-Zeev N, Denis B, Montgomery J, Alaerts M, Heyderman RS, Dance DA, Kennedy N, Feasey N, Moxon CA, 2013. Human melioidosis, Malawi, 2011. Emerg Infect Dis 19: 981–984.
-
12.
Wiersinga WJ, Birnie E, Weehuizen TA, Alabi AS, Huson MA, Huis RA, Mabala HK, Adzoda GK, Raczynski-Henk Y, Esen M, Lell B, Kremsner PG, Visser CE, Wuthiekanun V, Peacock SJ, van der Ende A, Limmathurotsakul D, Grobusch MP, 2015. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012–2013. Emerg Infect Dis 21: 40–47.
-
13.
DeShazer D, 2004. Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b. J Bacteriol 186: 3938–3950.
-
14.
Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC, Limmathurotsakul D, Chierakul W, Leendertse M, Florquin S, de Vos AF, White N, Dondorp AM, Day NP, Peacock SJ, van der Poll T, 2007. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis). PLoS Med 4: e248.
-
15.
Weehuizen TA, Wieland CW, van der Windt GJ, Duitman JW, Boon L, Day NP, Peacock SJ, van der Poll T, Wiersinga WJ, 2012. Expression and function of transforming growth factor beta in melioidosis. Infect Immun 80: 1853–1857.
-
16.
Hayden HS, Lim R, Brittnacher MJ, Sims EH, Ramage ER, Fong C, Wu Z, Crist E, Chang J, Zhou Y, Radey M, Rohmer L, Haugen E, Gillett W, Wuthiekanun V, Peacock SJ, Kaul R, Miller SI, Manoil C, Jacobs MA, 2012. Evolution of Burkholderia pseudomallei in recurrent melioidosis. PLoS One 7: e36507.
-
17.
Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, Nilsson C, Ariyaratne P, Ronning C, Losada L, Ruan Y, Sung WK, Woods D, Titball RW, Beacham I, Peak I, Keim P, Nierman WC, Tan P, 2010. A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS Pathog 6: e1000845.
-
18.
Tan GY, Liu Y, Sivalingam SP, Sim SH, Wang D, Paucod JC, Gauthier Y, Ooi EE, 2008. Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice. J Med Microbiol 57: 508–515.
-
19.
Ulett GC, Currie BJ, Clair TW, Mayo M, Ketheesan N, Labrooy J, Gal D, Norton R, Smith CA, Barnes J, Warner J, Hirst RG, 2001. Burkholderia pseudomallei virulence: definition, stability and association with clonality. Microbes Infect 3: 621–631.
-
20.
Hoppe I, Brenneke B, Rohde M, Kreft A, Häussler S, Reganzerowski A, Steinmetz I, 1999. Characterization of a murine model of melioidosis: comparison of different strains of mice. Infect Immun 67: 2891–2900.
-
21.
Price EP, Hornstra HM, Limmathurotsakul D, Max TL, Sarovich DS, Vogler AJ, Dale JL, Ginther JL, Leadem B, Colman RE, Foster JT, Tuanyok A, Wagner DM, Peacock SJ, Pearson T, Keim P, 2010. Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis. PLoS Pathog 6: e1000725.
-
22.
Vesaratchavest M, Tumapa S, Day NP, Wuthiekanun V, Chierakul W, Holden MT, White NJ, Currie BJ, Spratt BG, Feil EJ, Peacock SJ, 2006. Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence. J Clin Microbiol 44: 2553–2557.
-
23.
Sarovich DS, Garin B, De Smet B, Kaestli M, Mayo M, Vandamme P, Jacobs J, Lompo P, Tahita MC, Tinto H, Djaomalaza I, Currie BJ, Price EP, 2016. Phylogenomic analysis reveals an Asian origin for African Burkholderia pseudomallei and further supports melioidosis endemicity in Africa. mSphere 1: e00089-15.
-
24.
Didelot X, Walker AS, Peto TE, Crook DW, Wilson DJ, 2016. Within-host evolution of bacterial pathogens. Nat Rev Microbiol 14: 150–162.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 84243 | 83953 | 18469 |
| Full Text Views | 688 | 354 | 172 |
| PDF Downloads | 106 | 29 | 0 |
Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice
Tassili A. F. Weehuizen
Tassili A. F. Weehuizen
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
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Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
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Emma Birnie
Emma Birnie
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon.
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Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon.
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Bart Ferwerda
Bart Ferwerda
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
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Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
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Joris J. T. H. Roelofs
Joris J. T. H. Roelofs
Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
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Alex F. de Vos
Alex F. de Vos
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
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Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
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Martin P. Grobusch
Martin P. Grobusch
Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon.
Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Institute of Tropical Medicine, University of Tübingen, Germany.
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Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Institute of Tropical Medicine, University of Tübingen, Germany.
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W. Joost Wiersinga
W. Joost Wiersinga
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.
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Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.
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Burkholderia pseudomallei is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis “hotspots”; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by a B. pseudomallei strain recently isolated from a fatal Gabonese case with the Thai reference strain B. pseudomallei-1026b and Burkholderia thailandensis-E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the B. pseudomallei-1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of Burkholderia strains might contribute to the diverse global clinical occurrence of melioidosis.
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Author Notes
Authors' addresses: Tassili A. F. Weehuizen and Alex F. de Vos, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, and Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands, E-mails: t.a.weehuizen@amc.nl and a.f.devos@amc.uva.nl. Emma Birnie, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands, and Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon, E-mail: e.birnie@amc.nl. Bart Ferwerda, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands, and Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands, E-mail: e.b.ferwerda@amc.uva.nl. Joris J. T. H. Roelofs, Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands, E-mail: j.j.roelofs@amc.uva.nl. Martin P. Grobusch, Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon, Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands, and Institute of Tropical Medicine, University of Tübingen, Germany, E-mail: m.p.grobusch@amc.uva.nl. W. Joost Wiersinga, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands, and Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands, E-mail: w.j.wiersinga@amc.uva.nl.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Wiersinga WJ, Currie BJ, Peacock SJ, 2012. Melioidosis. N Engl J Med 367: 1035–1044.
-
2.
Cheng AC, Currie BJ, 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
3.
Centers for Disease Control and Prevention (CDC) Department of Health and Human Services (HHS), 2012. Possession, use, and transfer of select agents and toxins; biennial review. Final rule. Fed Regist 77: 61083–61115.
-
4.
Wiersinga WJ, de Vos AF, de Beer R, Wieland CW, Roelofs JJ, Woods DE, van der Poll T, 2008. Inflammation patterns induced by different Burkholderia species in mice. Cell Microbiol 10: 81–87.
-
5.
Brett PJ, DeShazer D, Woods DE, 1998. Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species. Int J Syst Bacteriol 48: 317–320.
-
6.
Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ, 2006. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol 4: 272–282.
-
7.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW, 2011. A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science 334: 821–824.
-
8.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
9.
Limmathurotsakul D, Golding N, Dance DAB, Messina JP, Pigott DM, Moyes CL, Rolim DB, Bertherat E, Day NP, Peacock SJ, Hay SI, 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
10.
Birnie E, Wiersinga WJ, Limmathurotsakul D, Grobusch MP, 2015. Melioidosis in Africa: should we be looking more closely? Future Microbiol 10: 273–281.
-
11.
Katangwe T, Purcell J, Bar-Zeev N, Denis B, Montgomery J, Alaerts M, Heyderman RS, Dance DA, Kennedy N, Feasey N, Moxon CA, 2013. Human melioidosis, Malawi, 2011. Emerg Infect Dis 19: 981–984.
-
12.
Wiersinga WJ, Birnie E, Weehuizen TA, Alabi AS, Huson MA, Huis RA, Mabala HK, Adzoda GK, Raczynski-Henk Y, Esen M, Lell B, Kremsner PG, Visser CE, Wuthiekanun V, Peacock SJ, van der Ende A, Limmathurotsakul D, Grobusch MP, 2015. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012–2013. Emerg Infect Dis 21: 40–47.
-
13.
DeShazer D, 2004. Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b. J Bacteriol 186: 3938–3950.
-
14.
Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC, Limmathurotsakul D, Chierakul W, Leendertse M, Florquin S, de Vos AF, White N, Dondorp AM, Day NP, Peacock SJ, van der Poll T, 2007. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis). PLoS Med 4: e248.
-
15.
Weehuizen TA, Wieland CW, van der Windt GJ, Duitman JW, Boon L, Day NP, Peacock SJ, van der Poll T, Wiersinga WJ, 2012. Expression and function of transforming growth factor beta in melioidosis. Infect Immun 80: 1853–1857.
-
16.
Hayden HS, Lim R, Brittnacher MJ, Sims EH, Ramage ER, Fong C, Wu Z, Crist E, Chang J, Zhou Y, Radey M, Rohmer L, Haugen E, Gillett W, Wuthiekanun V, Peacock SJ, Kaul R, Miller SI, Manoil C, Jacobs MA, 2012. Evolution of Burkholderia pseudomallei in recurrent melioidosis. PLoS One 7: e36507.
-
17.
Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, Nilsson C, Ariyaratne P, Ronning C, Losada L, Ruan Y, Sung WK, Woods D, Titball RW, Beacham I, Peak I, Keim P, Nierman WC, Tan P, 2010. A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS Pathog 6: e1000845.
-
18.
Tan GY, Liu Y, Sivalingam SP, Sim SH, Wang D, Paucod JC, Gauthier Y, Ooi EE, 2008. Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice. J Med Microbiol 57: 508–515.
-
19.
Ulett GC, Currie BJ, Clair TW, Mayo M, Ketheesan N, Labrooy J, Gal D, Norton R, Smith CA, Barnes J, Warner J, Hirst RG, 2001. Burkholderia pseudomallei virulence: definition, stability and association with clonality. Microbes Infect 3: 621–631.
-
20.
Hoppe I, Brenneke B, Rohde M, Kreft A, Häussler S, Reganzerowski A, Steinmetz I, 1999. Characterization of a murine model of melioidosis: comparison of different strains of mice. Infect Immun 67: 2891–2900.
-
21.
Price EP, Hornstra HM, Limmathurotsakul D, Max TL, Sarovich DS, Vogler AJ, Dale JL, Ginther JL, Leadem B, Colman RE, Foster JT, Tuanyok A, Wagner DM, Peacock SJ, Pearson T, Keim P, 2010. Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis. PLoS Pathog 6: e1000725.
-
22.
Vesaratchavest M, Tumapa S, Day NP, Wuthiekanun V, Chierakul W, Holden MT, White NJ, Currie BJ, Spratt BG, Feil EJ, Peacock SJ, 2006. Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence. J Clin Microbiol 44: 2553–2557.
-
23.
Sarovich DS, Garin B, De Smet B, Kaestli M, Mayo M, Vandamme P, Jacobs J, Lompo P, Tahita MC, Tinto H, Djaomalaza I, Currie BJ, Price EP, 2016. Phylogenomic analysis reveals an Asian origin for African Burkholderia pseudomallei and further supports melioidosis endemicity in Africa. mSphere 1: e00089-15.
-
24.
Didelot X, Walker AS, Peto TE, Crook DW, Wilson DJ, 2016. Within-host evolution of bacterial pathogens. Nat Rev Microbiol 14: 150–162.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 84243 | 83953 | 18469 |
| Full Text Views | 688 | 354 | 172 |
| PDF Downloads | 106 | 29 | 0 |